Reliability of physicians’ measurements when manually annotating images of microbial keratitis

After annotation area of ulcer was calculated. Image pixels were used as the unit of analysis because white‐to‐white distance was not measured Physicians’ annotations were evaluated for reliability using DICE similarity coefficient (DSC) and intraclass correlation coefficient (ICC) The DSC is the proportion of twice the number of pixels identified by both graders divided by the sum of pixels identified in each image. The DSC ranges from 0 (no overlap) to 1 (perfect overlap) and a coefficient >0.8 is considered good