A retrospective observational study of EEG findings and antiepileptic drug use among children referred for EEG to Zambia's University Teaching Hospital

Despite the heavy burden of epilepsy in Sub‐Saharan Africa, there remains a relative paucity of neurophysiology services and limited published data on electroencephalography (EEG) features among African children. The aim of this study was to describe clinical characteristics, EEG findings, and antiepileptic drug (AED) use among children referred for EEG to the University Teaching Hospital in Zambia.

[1]  W. Hauser,et al.  Utility of EEG Activation Procedures in Epilepsy: A Population-Based Study , 2017, Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society.

[2]  J. Wilmshurst,et al.  The role of melatonin to attain electroencephalograms in children in a sub-Saharan African setting , 2017, Seizure.

[3]  C. Newton,et al.  Prevalence, risk factors, and neurobehavioral comorbidities of epilepsy in Kenyan children , 2017, Epilepsia open.

[4]  Y. Gupta,et al.  Adverse effects & drug load of antiepileptic drugs in patients with epilepsy: Monotherapy versus polytherapy , 2017, The Indian journal of medical research.

[5]  Josemir W Sander,et al.  Electroencephalographic features of convulsive epilepsy in Africa: A multicentre study of prevalence, pattern and associated factors , 2016, Clinical Neurophysiology.

[6]  A. Ogunniyi,et al.  Electroencephalography as a tool for evidence-based diagnosis and improved outcomes in children with epilepsy in a resource-poor setting , 2015, The Pan African medical journal.

[7]  A. Winkler,et al.  Prevalence of Neurocysticercosis in People with Epilepsy in the Eastern Province of Zambia , 2015, PLoS neglected tropical diseases.

[8]  P. Camfield,et al.  Incidence, prevalence and aetiology of seizures and epilepsy in children. , 2015, Epileptic disorders : international epilepsy journal with videotape.

[9]  S. Ravat,et al.  Undue regulatory control on phenobarbital—an important yet overlooked reason for the epilepsy treatment gap , 2015, Epilepsia.

[10]  W. Theodore,et al.  Acute EEG findings in HIV-infected Zambian adults with new-onset seizure , 2015, Neurology.

[11]  Pierre-Marie Preux,et al.  Epidemiology, causes, and treatment of epilepsy in sub-Saharan Africa , 2014, The Lancet Neurology.

[12]  L. Lagae,et al.  The challenges and innovations for therapy in children with epilepsy , 2014, Nature Reviews Neurology.

[13]  Francesco Brigo,et al.  Patterns of diagnosis and therapeutic care of epilepsy at a tertiary referral center in Nigeria , 2014, Epilepsia.

[14]  Josemir W Sander,et al.  Clinical features, proximate causes, and consequences of active convulsive epilepsy in Africa , 2013, Epilepsia.

[15]  M. Prevett.  Epilepsy in sub-Saharan Africa , 2013, Practical Neurology.

[16]  Josemir W Sander,et al.  Phenobarbital: missing in action. , 2012, Bulletin of the World Health Organization.

[17]  Josemir W Sander,et al.  Cognitive and mood effects of phenobarbital treatment in people with epilepsy in rural China: a prospective study , 2012, Journal of Neurology, Neurosurgery & Psychiatry.

[18]  J. Wilmshurst,et al.  The Usefulness of Electroencephalograms in a Survey of Children From the Western Cape of South Africa , 2012, Journal of child neurology.

[19]  B. Neville,et al.  Epilepsy in Tanzanian children: Association with perinatal events and other risk factors , 2012, Epilepsia.

[20]  D. Clifford,et al.  Antiepileptic drug selection for people with HIV/AIDS: Evidence‐based guidelines from the ILAE and AAN , 2012, Epilepsia.

[21]  P. Singhi.  Infectious causes of seizures and epilepsy in the developing world , 2011, Developmental medicine and child neurology.

[22]  Frcp,et al.  Blantyre Malaria Project Epilepsy Study (BMPES) of neurological outcomes in retinopathy-positive paediatric cerebral malaria survivors: a prospective cohort study , 2010, The Lancet Neurology.

[23]  Josemir W Sander,et al.  Clinical and neurophysiologic features of active convulsive epilepsy in rural Kenya: A population‐based study , 2010, Epilepsia.

[24]  C. Panayiotopoulos.  Antiepileptic Drugs, Pharmacopoeia , 2010 .

[25]  G. Birbeck,et al.  The current availability of antiepileptic drugs in Zambia: implications for the ILAE/WHO "out of the shadows" campaign. , 2010, The American journal of tropical medicine and hygiene.

[26]  Shekhar Saxena,et al.  Global disparities in the epilepsy treatment gap: a systematic review. , 2010, Bulletin of the World Health Organization.

[27]  Christian Bottomley,et al.  Estimation of the burden of active and life-time epilepsy: A meta-analytic approach , 2010, Epilepsia.

[28]  B. Bourgeois,et al.  Aggravation of epilepsy by antiepileptic drugs. , 2005, Pediatric neurology.

[29]  B. Neville,et al.  Increased Prevalence of Epilepsy Associated with Severe Falciparum Malaria in Children , 2004, Epilepsia.

[30]  Josemir W Sander.  The Use of Antiepileptic Drugs—Principles and Practice , 2004, Epilepsia.

[31]  C. Benninger,et al.  Clinical and electro-clinical classification of epileptic seizure in west Uganda. , 2000, Bulletin de la Societe de pathologie exotique.

[32]  G. Birbeck.  Seizures in Rural Zambia , 2000, Epilepsia.

[33]  B. Adamolekun,et al.  Electroencephalographic photosensitivity among Zimbabwean youths. , 1998, Annals of tropical paediatrics.

[34]  Anthony L. Johnson,et al.  Randomised controlled trial to assess acceptability of phenobarbital for childhood epilepsy in rural India , 1998, The Lancet.

[35]  B. Adamolekun,et al.  The influence of racial and environmental factors on EEG photoparoxysmal responses in Zimbabwe , 1998, Acta neurologica Scandinavica.

[36]  S. Ravat,et al.  Erratum: Undue regulatory control on phenobarbital - An important yet overlooked reason for the epilepsy treatment gap (Epilepsia (2015) 56 (659-662)) , 2015 .

[37]  Brahim Tabarki,et al.  Antiepileptic drugs , 2014, Reactions Weekly.

[38]  G. Birbeck,et al.  Evidence-Based Guidelines for EEG Utilization at the University Teaching Hospital (UTH). , 2011, Medical journal of Zambia.