An Exploratory Cohort Study of the Association between the Level of Testosterone and Suicidal Ideation in Hospitalized Adolescent Females with Depression in China

Background To date, around 4 per 100,000 adolescents committed suicide within the 29 OECD countries. The suicidal behavior is related to psychological factors, genetics, neurobiology, and other biomarkers. The aim of this study was to examine risk factors for the development of suicidal ideation in adolescent females with depression, focusing on the relationship between different testosterone levels and suicidal ideation, in order to help develop strategies to intervene in suicidal behavior in female adolescents with depression. Method In this single-center prospective cohort study, we enrolled adolescent females with depression. We collected information on their baseline data, testosterone levels, symptom self-rating scale scores, suicidal ideation, non-suicidal self-injurious (NSSI) behaviours, and suicide attempts. We used multivariate logistic regression to identify risk factors for the development of suicidal ideation in adolescent females with depression. Results A total of 113 hospitalized adolescent females were enrolled with a mean age of 13.5 (1.20). Among these patients, there were 86 (76.11%) subjects who suffered from suicidal ideation, 59 (52.21%) had NSSI and 23 (20.35%) had suicide attempt behavior. In the final model, higher level of testosterone (p=0.04) and higher age (p=0.02) were associated with the higher odds of having suicidal ideation. Conclusion In this exploratory cohort study, the emergence of suicidal ideation was common among adolescent females with depression. This study is consistent with the other studies. It shows that the age is a potential predictor for suicidal ideation in hospitalized adolescent females with depression.

[1]  Yan Liu,et al.  An Exploratory Cohort Study of the Association Between the Level of Testosterone and Suicidal Ideation in the Hospitalized Adolescent Female With Depression in China , 2021 .

[2]  R. Yehuda,et al.  The effect of oral dexamethasone administration on testosterone levels in combat veterans with or without a history of suicide attempt. , 2020, Journal of psychiatric research.

[3]  Jill Ehrenreich-May,et al.  Changes in Risk Factors During the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders in Adolescents. , 2020, Behavior therapy.

[4]  N. Kalin.  Insights Into Suicide and Depression. , 2020, The American journal of psychiatry.

[5]  R. Manni,et al.  Behavioural and emotional profiles of children and adolescents with disorders of arousal , 2020, Journal of sleep research.

[6]  O. Dan.  Recognition of emotional facial expressions in adolescents with attention deficit/hyperactivity disorder. , 2020, Journal of adolescence.

[7]  S. Madigan,et al.  Depression and Inflammation Among Children and Adolescents: A Meta-analysis , 2020, Biological Psychiatry.

[8]  T. Furukawa.  Adolescent depression: from symptoms to individualised treatment? , 2020, The lancet. Psychiatry.

[9]  A. Spirito,et al.  Cannabis Use and Emotional Awareness Difficulties in Adolescents with Co-Occurring Substance Use and Psychiatric Disorders , 2020, Substance use & misuse.

[10]  U. Habel,et al.  Effects of exogenous testosterone application on network connectivity within emotion regulation systems , 2020, Scientific Reports.

[11]  M. Usai,et al.  Cognitive and emotional regulation in adolescents and young women with eating disorders , 2020, Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity.

[12]  V. Harder,et al.  Improving Adolescent Depression Screening in Pediatric Primary Care. , 2019, Academic pediatrics.

[13]  David A. Brent,et al.  Suicide and suicide risk , 2019, Nature Reviews Disease Primers.

[14]  Rachel Washburn.  Conceptual Frameworks in Scientific Inquiry and the Centers for Disease Control and Prevention's Approach to Pesticide Toxicity (1948-1968). , 2019, American journal of public health.

[15]  J. Ogrodniczuk,et al.  Men’s Depression and Suicide , 2019, Current Psychiatry Reports.

[16]  G. O’Callaghan,et al.  Reward Processing in Adolescent Depression Across Neuroimaging Modalities. , 2019, Zeitschrift fur Kinder- und Jugendpsychiatrie und Psychotherapie.

[17]  F. Minhas,et al.  Prevalence of Suicide Ideation and its Relationship with Depression among Transgender Population. , 2019, Journal of the College of Physicians and Surgeons--Pakistan : JCPSP.

[18]  H. Yao,et al.  [Overview of multivariate regression model analysis and application]. , 2019, Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine].

[19]  M. Möller,et al.  Uppsala Longitudinal Adolescent Depression Study (ULADS) , 2019, BMJ Open.

[20]  Benito León-del-Barco,et al.  Parental Psychological Control and Emotional and Behavioral Disorders among Spanish Adolescents , 2019, International journal of environmental research and public health.

[21]  J. Buitelaar,et al.  Psychosocial risk factors for suicidality in children and adolescents , 2019, European Child & Adolescent Psychiatry.

[22]  K. Keyes,et al.  Oral contraceptive use and depression among adolescents. , 2019, Annals of epidemiology.

[23]  T. Lange,et al.  Validation of the Edinburgh Postnatal Depression Scale against both DSM-5 and ICD-10 diagnostic criteria for depression , 2018, BMC Psychiatry.

[24]  Yogesh K. Dwivedi,et al.  Chronic Testosterone Increases Impulsivity and Influences the Transcriptional Activity of the Alpha-2A Adrenergic Receptor Signaling Pathway in Rat Brain , 2018, Molecular Neurobiology.

[25]  H. Nandeesha,et al.  Elevated interleukin-17 and reduced testosterone in bipolar disorder. Relation with suicidal behaviour. , 2018, Asian journal of psychiatry.

[26]  M. Maroufi,et al.  Comparison of salivary testosterone levels in different phases of bipolar I disorder and control group , 2018, Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences.

[27]  Eun-hee Jung,et al.  A Comparative Study of Suicide Rates among 10–19-Year-Olds in 29 OECD Countries , 2018, Psychiatry investigation.

[28]  Y. Ye,et al.  [A meta-analysis of Symptom Checklist-90 assessment results in Chinese nurses]. , 2018, Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases.

[29]  E. Sougey,et al.  Suicide in childhood: a literatura review. , 2017, Ciencia & saude coletiva.

[30]  Timothy R. Rice,et al.  Adolescent suicide and testosterone , 2017, International journal of adolescent medicine and health.

[31]  L. Sher.  Commentary: CSF and Plasma Testosterone in Attempted Suicide , 2017, Front. Public Health.

[32]  Rebecca C. Brown,et al.  Non-suicidal Self-Injury in Adolescence , 2017, Current Psychiatry Reports.

[33]  Eric D A Hermes,et al.  Multimodal Neuroimaging of Frontolimbic Structure and Function Associated With Suicide Attempts in Adolescents and Young Adults With Bipolar Disorder. , 2017, The American journal of psychiatry.

[34]  Lisa S. Rotenstein,et al.  Prevalence of Depression, Depressive Symptoms, and Suicidal Ideation Among Medical Students: A Systematic Review and Meta-Analysis. , 2016, JAMA.

[35]  S. Arver,et al.  CSF and plasma testosterone in attempted suicide , 2016, Psychoneuroendocrinology.

[36]  Timothy Verstynen,et al.  Adolescent brain development and depression: A case for the importance of connectivity of the anterior cingulate cortex , 2016, Neuroscience & Biobehavioral Reviews.

[37]  J. Bridge,et al.  Suicide in Elementary School-Aged Children and Early Adolescents , 2016, Pediatrics.

[38]  S. Hollon,et al.  Prevention of Depression in At-Risk Adolescents: Predictors and Moderators of Acute Effects. , 2016, Journal of the American Academy of Child and Adolescent Psychiatry.

[39]  K. Wagner,et al.  Management of Treatment-Resistant Depression in Children and Adolescents , 2014, Pediatric Drugs.

[40]  H. Blumberg,et al.  Neurobiological risk factors for suicide: insights from brain imaging. , 2014, American journal of preventive medicine.

[41]  E. Hull,et al.  Sex differences in anxiety and depression: Role of testosterone , 2014, Frontiers in Neuroendocrinology.

[42]  R. Bryant.  Prolonged grief: where to after Diagnostic and Statistical Manual of Mental Disorders, 5th Edition? , 2014, Current opinion in psychiatry.

[43]  L. Spear,et al.  Puberty and gonadal hormones: Role in adolescent-typical behavioral alterations , 2013, Hormones and Behavior.

[44]  C. Bellantuono,et al.  Adolescent depression: clinical features and therapeutic strategies. , 2013, European review for medical and pharmacological sciences.

[45]  Yan Chen,et al.  [Prevalence of suicide ideation among middle school students in China: a systematic analysis of studies between 2000 and 2012]. , 2013, Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi.

[46]  Emma Ashwin,et al.  Fetal Testosterone Influences Sexually Dimorphic Gray Matter in the Human Brain , 2012, The Journal of Neuroscience.

[47]  J. Strawn,et al.  Neuroendocrine aspects of pediatric aggression: Can hormone measures be clinically useful? , 2010, Neuropsychiatric disease and treatment.

[48]  Z. Rihmer,et al.  Depression and suicide - the role of underlying bipolarity. , 2019, Psychiatria Hungarica : A Magyar Pszichiatriai Tarsasag tudomanyos folyoirata.