A 5 $\mu$ W/Channel Spectral Analysis IC for Chronic Bidirectional Brain–Machine Interfaces

This paper describes an amplification and spectral processing IC for extracting key bioelectrical signals, or ldquobiomarkersrdquo, which are expressed in the brain's field potentials. The intent is to explore using these biomarkers to drive prosthetic actuators or titrate therapy devices such as a deep-brain neurostimulator. The prototype IC uses 5 muW/channel to resolve signals on the order of 1 muVrms. The four channels on the device provide independent spectral analysis from DC to 1 kHz, with variable bandwidth and power filtering characteristics. The noise floor and flexible spectral processing support a broad range of potential applications including sleep staging, Parkinson's disease, detection of movement intention for neuroprosthesis, and detection of high frequency ldquofast ripplesrdquo for exploring seizure prediction. To fully demonstrate the IC's functionality, we include results from a prototype ldquoclosed-looprdquo neurostimulator implementing adaptive titration of therapy based on measured field potential activity.

[1]  Jaijeet Roychowdhury,et al.  Cyclostationary noise analysis of large RF circuits with multitone excitations , 1998 .

[2]  Jongwoo Lee,et al.  A 64 Channelprogrammable closed-loop deep brain stimulator with 8 channel neural amplifier and logarithmic ADC , 2008, 2008 IEEE Symposium on VLSI Circuits.

[3]  J. A. Wilson,et al.  Two-dimensional movement control using electrocorticographic signals in humans , 2008, Journal of neural engineering.

[4]  Andrea A. Kühn,et al.  High-Frequency Stimulation of the Subthalamic Nucleus Suppresses Oscillatory β Activity in Patients with Parkinson's Disease in Parallel with Improvement in Motor Performance , 2008, The Journal of Neuroscience.

[5]  Timothy Denison,et al.  A 2.2/spl mu/W 94nV//spl radic/Hz, Chopper-Stabilized Instrumentation Amplifier for EEG Detection in Chronic Implants , 2007, 2007 IEEE International Solid-State Circuits Conference. Digest of Technical Papers.

[6]  M.A.T. Sanduleanu,et al.  A low noise, low residual offset, chopped amplifier for mixed level applications , 1998, 1998 IEEE International Conference on Electronics, Circuits and Systems. Surfing the Waves of Science and Technology (Cat. No.98EX196).

[7]  Jesse C. Dean,et al.  The Effect of Lateral Stabilization on Walking in Young and Old Adults , 2007, IEEE Transactions on Biomedical Engineering.

[8]  Rahul Sarpeshkar,et al.  A practical micropower programmable bandpass filter for use in bionic ears , 2003, IEEE J. Solid State Circuits.

[9]  W. Siebert.  Circuits, Signals and Systems , 1985 .

[10]  B. Litt,et al.  Automatic detection of high frequency epileptiform oscillations from intracranial EEG recordings of patients with neocortical epilepsy , 2005, 2005 IEEE Region 5 and IEEE Denver Section Technical, Professional and Student Development Workshop.

[11]  Brian Litt,et al.  Detection of seizure precursors from depth-EEG using a sign periodogram transform , 2003, IEEE Transactions on Biomedical Engineering.

[12]  Steven B. Leeb,et al.  Computer-aided design and application of sinusoidal switching patterns , 1998, COM.P.EL.98. Record 6th Workshop on Computer in Power Electronics (Cat. No.98TH8358).

[13]  Scott K. Arfin,et al.  Low-Power Circuits for Brain-Machine Interfaces , 2007, 2007 IEEE International Symposium on Circuits and Systems.

[14]  N. Kopell,et al.  Olfactory Bulb Gamma Oscillations Are Enhanced with Task Demands , 2007, The Journal of Neuroscience.

[15]  Refet Firat Yazicioglu,et al.  A 200 $\mu$ W Eight-Channel EEG Acquisition ASIC for Ambulatory EEG Systems , 2008, IEEE Journal of Solid-State Circuits.

[16]  D.A. Heldman,et al.  Local field potential spectral tuning in motor cortex during reaching , 2006, IEEE Transactions on Neural Systems and Rehabilitation Engineering.

[17]  Gregory Molnar,et al.  An 8μW Heterodyning Chopper Amplifier for Direct Extraction of 2μVrms Neuronal Biomarkers , 2008, 2008 IEEE International Solid-State Circuits Conference - Digest of Technical Papers.

[18]  W. Santa,et al.  Micropower Sensors for Neuroprosthetics , 2007, 2007 IEEE Sensors.

[20]  J.W. Burdick,et al.  Recording advances for neural prosthetics , 2004, The 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[21]  Brian Litt,et al.  High-Frequency Oscillations Detected in Epileptic Networks Using Swarmed Neural-Network Features , 2007, Annals of Biomedical Engineering.

[22]  A.-T. Avestruz,et al.  A 2 $\mu\hbox{W}$ 100 nV/rtHz Chopper-Stabilized Instrumentation Amplifier for Chronic Measurement of Neural Field Potentials , 2007, IEEE Journal of Solid-State Circuits.

[23]  G. Pfurtscheller,et al.  Conversion of EEG activity into cursor movement by a brain-computer interface (BCI) , 2004, IEEE Transactions on Neural Systems and Rehabilitation Engineering.

[24]  Rahul Sarpeshkar,et al.  An Energy-Efficient Micropower Neural Recording Amplifier , 2007, IEEE Transactions on Biomedical Circuits and Systems.

[25]  P. Stypulkowski,et al.  Electrical stimulation as therapy for neurological disorders , 2006, IEEE Engineering in Medicine and Biology Magazine.

[26]  Wouter A. Serdijn,et al.  An ultra low-power dynamic translinear cardiac sense amplifier for pacemakers , 2003, Proceedings of the 2003 International Symposium on Circuits and Systems, 2003. ISCAS '03..

[27]  A. Priori,et al.  An electronic device for artefact suppression in human local field potential recordings during deep brain stimulation , 2007, Journal of neural engineering.

[28]  A. Hadiashar,et al.  A Chopper Stabilized CMOS Analog Multiplier with Ultra Low DC Offsets , 2006, 2006 Proceedings of the 32nd European Solid-State Circuits Conference.

[29]  Andrew B. Schwartz,et al.  Brain-Controlled Interfaces: Movement Restoration with Neural Prosthetics , 2006, Neuron.

[30]  Leslie M Kay,et al.  Information processing in the olfactory systems of insects and vertebrates. , 2006, Seminars in cell & developmental biology.

[31]  Dean J. Krusienski,et al.  A μ -Rhythm Matched Filter for Continuous Control of a Brain-Computer Interface , 2007, IEEE Trans. Biomed. Eng..

[32]  W. Freeman,et al.  Spatial spectral analysis of human electrocorticograms including the alpha and gamma bands , 2000, Journal of Neuroscience Methods.

[33]  G. Buzsáki,et al.  Neuronal Oscillations in Cortical Networks , 2004, Science.

[34]  R.R. Harrison,et al.  Local field potential measurement with low-power analog integrated circuit , 2004, The 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[35]  Annamaria Bianchi,et al.  Basal ganglia local field potentials: applications in the development of new deep brain stimulation devices for movement disorders , 2007, Expert review of medical devices.

[36]  R. Andersen,et al.  Selecting the signals for a brain–machine interface , 2004, Current Opinion in Neurobiology.

[37]  Wouter A. Serdijn,et al.  Analog wavelet transform employing dynamic translinear circuits for cardiac signal characterization , 2003, Proceedings of the 2003 International Symposium on Circuits and Systems, 2003. ISCAS '03..

[38]  Gabor C. Temes,et al.  Circuit techniques for reducing the effects of op-amp imperfections: autozeroing, correlated double sampling, and chopper stabilization , 1996, Proc. IEEE.

[39]  F. Cogiamanian,et al.  Subthalamic local field potential oscillations during ongoing deep brain stimulation in Parkinson's disease , 2008, Brain Research Bulletin.

[40]  A. Pérez-Villalba.  Rhythms of the Brain, G. Buzsáki. Oxford University Press, Madison Avenue, New York (2006), Price: GB £42.00, p. 448, ISBN: 0-19-530106-4 , 2008 .

[41]  Rahul Sarpeshkar,et al.  An ultra-low-power programmable analog bionic ear processor , 2005, IEEE Transactions on Biomedical Engineering.

[42]  S. Debener,et al.  Is Resting Anterior EEG Alpha Asymmetry a Trait Marker for Depression? , 2000, Neuropsychobiology.

[43]  G. Buzsáki.  Rhythms of the brain , 2006 .

[44]  Gerwin Schalk,et al.  A brain–computer interface using electrocorticographic signals in humans , 2004, Journal of neural engineering.

[45]  W. Santa,et al.  A 2μW Three-Axis MEMS-based Accelerometer , 2007, 2007 IEEE Instrumentation & Measurement Technology Conference IMTC 2007.

[46]  B. Litt,et al.  High-frequency oscillations and seizure generation in neocortical epilepsy. , 2004, Brain : a journal of neurology.

[47]  G.J. Gage,et al.  Information Capacity of Brain Machine Interfaces , 2005, 2005 IEEE Engineering in Medicine and Biology 27th Annual Conference.

[48]  R.R. Harrison,et al.  A Low-Power Integrated Circuit for a Wireless 100-Electrode Neural Recording System , 2006, IEEE Journal of Solid-State Circuits.

[49]  J.R. Wolpaw,et al.  A $\mu $-Rhythm Matched Filter for Continuous Control of a Brain-Computer Interface , 2007, IEEE Transactions on Biomedical Engineering.

[50]  A. Bakker,et al.  A CMOS nested-chopper instrumentation amplifier with 100-nV offset , 2000, IEEE Journal of Solid-State Circuits.

[51]  Rajesh P. N. Rao,et al.  Spectral Changes in Cortical Surface Potentials during Motor Movement , 2007, The Journal of Neuroscience.

[52]  R. R. Harrison,et al.  A low-power low-noise CMOS amplifier for neural recording applications , 2003, IEEE J. Solid State Circuits.