Conformational Plasticity of GPCR Binding Sites
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L. Pardo | J. Ballesteros | Lei Shi | J. Javitch | X. Deupí | C. Govaerts
[1] S. Vishveshwara,et al. Geometry of proline-containing alpha-helices in proteins. , 2009, International journal of peptide and protein research.
[2] C. Deber,et al. Influence of glycine residues on peptide conformation in membrane environments. , 2009, International journal of peptide and protein research.
[3] M. J. Lemieux,et al. Proline residues in transmembrane segment IV are critical for activity, expression and targeting of the Na+/H+ exchanger isoform 1. , 2004, The Biochemical journal.
[4] O. Lichtarge,et al. Evolutionary Trace of G Protein-coupled Receptors Reveals Clusters of Residues That Determine Global and Class-specific Functions* , 2004, Journal of Biological Chemistry.
[5] E. Pérez-Payá,et al. Influence of proline residues in transmembrane helix packing. , 2004, Journal of molecular biology.
[6] Yang Xiang,et al. Sequential binding of agonists to the beta2 adrenoceptor. Kinetic evidence for intermediate conformational states. , 2004, The Journal of biological chemistry.
[7] H. Schiöth,et al. The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints. , 2003, Molecular pharmacology.
[8] Krzysztof Palczewski,et al. Sequence analyses of G-protein-coupled receptors: similarities to rhodopsin. , 2003, Biochemistry.
[9] Shoshana J. Wodak,et al. Activation of CCR5 by Chemokines Involves an Aromatic Cluster between Transmembrane Helices 2 and 3* , 2003, The Journal of Biological Chemistry.
[10] F. Cordes,et al. Proline-induced distortions of transmembrane helices. , 2002, Journal of molecular biology.
[11] J. Ballesteros,et al. Beta2 adrenergic receptor activation. Modulation of the proline kink in transmembrane 6 by a rotamer toggle switch. , 2002, The Journal of biological chemistry.
[12] F. Cordes,et al. Conformational dynamics of helix S6 from Shaker potassium channel: simulation studies. , 2002, Biopolymers.
[13] S. Miura,et al. Constitutive Activation of Angiotensin II Type 1 Receptor Alters the Orientation of Transmembrane Helix-2* , 2002, The Journal of Biological Chemistry.
[14] L. Pardo,et al. Design, synthesis and pharmacological evaluation of 5-hydroxytryptamine(1a) receptor ligands to explore the three-dimensional structure of the receptor. , 2002, Molecular pharmacology.
[15] S. Mitaku,et al. Identification of G protein‐coupled receptor genes from the human genome sequence , 2002, FEBS letters.
[16] K. Martin,et al. The critical role of transmembrane prolines in human prostacyclin receptor activation. , 2002, Molecular pharmacology.
[17] Yoshinori Shichida,et al. Functional role of internal water molecules in rhodopsin revealed by x-ray crystallography , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[18] D. Engelman,et al. Motifs of serine and threonine can drive association of transmembrane helices. , 2002, Journal of molecular biology.
[19] E. Querol,et al. Thr90 is a key residue of the bacteriorhodopsin proton pumping mechanism , 2001, FEBS letters.
[20] A. Rees,et al. The hunchback and its neighbours: proline as an environmental modulator. , 2001, Trends in biochemical sciences.
[21] J W Saldanha,et al. Transmembrane Domains 4 and 7 of the M1Muscarinic Acetylcholine Receptor Are Critical for Ligand Binding and the Receptor Activation Switch* , 2001, The Journal of Biological Chemistry.
[22] K. Neve,et al. Modeling and mutational analysis of a putative sodium-binding pocket on the dopamine D2 receptor. , 2001, Molecular pharmacology.
[23] M S Sansom,et al. Proline‐induced hinges in transmembrane helices: Possible roles in ion channel gating , 2001, Proteins.
[24] P Ghanouni,et al. Functionally Different Agonists Induce Distinct Conformations in the G Protein Coupling Domain of the β2Adrenergic Receptor* , 2001, The Journal of Biological Chemistry.
[25] R. Zare,et al. Single-molecule spectroscopy of the β2 adrenergic receptor: Observation of conformational substates in a membrane protein , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[26] J. Ballesteros,et al. Structural mimicry in G protein-coupled receptors: implications of the high-resolution structure of rhodopsin for structure-function analysis of rhodopsin-like receptors. , 2001, Molecular pharmacology.
[27] S. Wodak,et al. A Conserved Asn in Transmembrane Helix 7 Is an On/Off Switch in the Activation of the Thyrotropin Receptor* , 2001, The Journal of Biological Chemistry.
[28] K. Palczewski,et al. Activation of rhodopsin: new insights from structural and biochemical studies. , 2001, Trends in biochemical sciences.
[29] Shoshana J. Wodak,et al. The TXP Motif in the Second Transmembrane Helix of CCR5 , 2001, The Journal of Biological Chemistry.
[30] Timothy B. Stockwell,et al. The Sequence of the Human Genome , 2001, Science.
[31] J. V. Moran,et al. Initial sequencing and analysis of the human genome. , 2001, Nature.
[32] J. Ballesteros,et al. The Forgotten Serine , 2000, The Journal of Biological Chemistry.
[33] G Vriend,et al. Receptors coupling to G proteins: Is there a signal behind the sequence? , 2000, Proteins.
[34] Mark S.P. Sansom,et al. Hinges, swivels and switches: the role of prolines in signalling via transmembrane α-helices , 2000 .
[35] Leonardo Pardo,et al. Serine and Threonine Residues Bend α-Helices in the χ1 = g− Conformation , 2000 .
[36] K. Palczewski,et al. Crystal Structure of Rhodopsin: A G‐Protein‐Coupled Receptor , 2002, Chembiochem : a European journal of chemical biology.
[37] M. Gerstein,et al. Statistical analysis of amino acid patterns in transmembrane helices: the GxxxG motif occurs frequently and in association with beta-branched residues at neighboring positions. , 2000, Journal of molecular biology.
[38] U. Gether. Uncovering molecular mechanisms involved in activation of G protein-coupled receptors. , 2000, Endocrine reviews.
[39] J. Ballesteros,et al. The role of a conserved proline residue in mediating conformational changes associated with voltage gating of Cx32 gap junctions. , 1999, Biophysical journal.
[40] G von Heijne,et al. A turn propensity scale for transmembrane helices. , 1999, Journal of molecular biology.
[41] E C Hulme,et al. The Functional Topography of Transmembrane Domain 3 of the M1 Muscarinic Acetylcholine Receptor, Revealed by Scanning Mutagenesis* , 1999, The Journal of Biological Chemistry.
[42] D. Cafiso,et al. The role of proline and glycine in determining the backbone flexibility of a channel-forming peptide. , 1999, Biophysical journal.
[43] K D Ridge,et al. Light-induced exposure of the cytoplasmic end of transmembrane helix seven in rhodopsin. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[44] M. Grossmann,et al. G Protein-coupled Receptors , 1998, The Journal of Biological Chemistry.
[45] D. Langosch,et al. The dimerization motif of the glycophorin A transmembrane segment in membranes: Importance of glycine residues , 1998, Protein science : a publication of the Protein Society.
[46] H. Bourne,et al. How receptors talk to trimeric G proteins. , 1997, Current opinion in cell biology.
[47] T. Ji,et al. Roles of Transmembrane Prolines and Proline-induced Kinks of the Lutropin/Choriogonadotropin Receptor* , 1997, The Journal of Biological Chemistry.
[48] J. Breed,et al. Simulation studies of alamethicin-bilayer interactions. , 1997, Biophysical journal.
[49] Brian K. Kobilka,et al. Structural Instability of a Constitutively Active G Protein-coupled Receptor , 1997, The Journal of Biological Chemistry.
[50] H. Khorana,et al. Requirement of Rigid-Body Motion of Transmembrane Helices for Light Activation of Rhodopsin , 1996, Science.
[51] H. Khorana,et al. Structural features and light-dependent changes in the cytoplasmic interhelical E-F loop region of rhodopsin: a site-directed spin-labeling study. , 1996, Biochemistry.
[52] Kenneth A Jacobson,et al. Molecular architecture of G protein‐coupled receptors , 1996, Drug development research.
[53] Jonathan A Javitch,et al. Mapping the binding-site crevice of the dopamine D2 receptor by the substituted-cysteine accessibility method , 1995, Neuron.
[54] D. Engelman,et al. A dimerization motif for transmembrane α–helices , 1994, Nature Structural Biology.
[55] S. Vishveshwara,et al. Characterization of proline‐containing α‐helix (helix F model of bacteriorhodopsin) by molecular dynamics studies , 1993, Proteins.
[56] P. Kraulis. A program to produce both detailed and schematic plots of protein structures , 1991 .
[57] Gunnar von Heijne,et al. Proline kinks in transmembrane α-helices☆ , 1991 .
[58] J. Thornton,et al. Influence of proline residues on protein conformation. , 1991, Journal of molecular biology.
[59] R. H. Yun,et al. Proline in α‐helix: Stability and conformation studied by dynamics simulation , 1991 .
[60] Dudley H. Williams,et al. The influence of proline residues on α‐helical structure , 1990 .
[61] J. Richardson,et al. Amino acid preferences for specific locations at the ends of alpha helices. , 1988, Science.
[62] J. Thornton,et al. Helix geometry in proteins. , 1988, Journal of molecular biology.
[63] B. Matthews,et al. Intrahelical hydrogen bonding of serine, threonine and cysteine residues within alpha-helices and its relevance to membrane-bound proteins. , 1984, Journal of molecular biology.
[64] Leonardo Pardo,et al. Ser and Thr Residues Modulate the Conformation of Pro-Kinked Transmembrane α-Helices , 2004 .
[65] Gert Vriend,et al. GPCRDB information system for G protein-coupled receptors , 2003, Nucleic Acids Res..
[66] Harel Weinstein,et al. Three-dimensional representations of G protein-coupled receptor structures and mechanisms. , 2002, Methods in enzymology.
[67] J. Ballesteros,et al. Agonist alkyl tail interaction with cannabinoid CB1 receptor V6.43/I6.46 groove induces a helix 6 active conformation , 2002 .
[68] P. Molinari,et al. Catechol-binding serines of beta(2)-adrenergic receptors control the equilibrium between active and inactive receptor states. , 2000, Molecular pharmacology.
[69] E A Merritt,et al. Raster3D: photorealistic molecular graphics. , 1997, Methods in enzymology.
[70] J. Ballesteros,et al. [19] Integrated methods for the construction of three-dimensional models and computational probing of structure-function relations in G protein-coupled receptors , 1995 .
[71] T L Blundell,et al. The evolution and structure of aminergic G protein-coupled receptors. , 1994, Receptors & channels.