AMPK: a nutrient and energy sensor that maintains energy homeostasis
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[1] B. Kemp,et al. AMPK functions as an adenylate charge-regulated protein kinase , 2012, Trends in Endocrinology & Metabolism.
[2] N. Perkins. Cysteine 38 holds the key to NF-κB activation. , 2012, Molecular cell.
[3] S. Gygi,et al. Chemical genetic screen for AMPKα2 substrates uncovers a network of proteins involved in mitosis. , 2011, Molecular cell.
[4] R. McCartney,et al. Subunit and Domain Requirements for Adenylate-mediated Protection of Snf1 Kinase Activation Loop from Dephosphorylation* , 2011, The Journal of Biological Chemistry.
[5] David Carling,et al. ADP Regulates SNF1, the Saccharomyces cerevisiae Homolog of AMP-Activated Protein Kinase , 2011, Cell metabolism.
[6] Z. Andrews. Central mechanisms involved in the orexigenic actions of ghrelin , 2011, Peptides.
[7] Mak-Soon Lee,et al. Reduction of body weight by dietary garlic is associated with an increase in uncoupling protein mRNA expression and activation of AMP-activated protein kinase in diet-induced obese mice. , 2011, The Journal of nutrition.
[8] M. Dallas,et al. Phosphorylation of the voltage-gated potassium channel Kv2.1 by AMP-activated protein kinase regulates membrane excitability , 2011, Proceedings of the National Academy of Sciences.
[9] S. Sternson,et al. Hunger States Switch a Flip-Flop Memory Circuit via a Synaptic AMPK-Dependent Positive Feedback Loop , 2011, Cell.
[10] M. Tarnopolsky,et al. AMP-activated protein kinase (AMPK) β1β2 muscle null mice reveal an essential role for AMPK in maintaining mitochondrial content and glucose uptake during exercise , 2011, Proceedings of the National Academy of Sciences.
[11] S. Gamblin,et al. AMP-activated protein kinase: also regulated by ADP? , 2011, Trends in biochemical sciences.
[12] B. Kemp,et al. AMPK Is a Direct Adenylate Charge-Regulated Protein Kinase , 2011, Science.
[13] R. Evans,et al. Class IIa Histone Deacetylases Are Hormone-Activated Regulators of FOXO and Mammalian Glucose Homeostasis , 2011, Cell.
[14] Mengwei Zang,et al. AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice. , 2011, Cell metabolism.
[15] David Carling,et al. Structure of Mammalian AMPK and its regulation by ADP , 2011, Nature.
[16] B. Viollet,et al. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1 , 2011, Nature Cell Biology.
[17] B. Viollet,et al. Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy , 2011, Science.
[18] D. Wasserman,et al. Mice with AS160/TBC1D4-Thr649Ala Knockin Mutation Are Glucose Intolerant with Reduced Insulin Sensitivity and Altered GLUT4 Trafficking , 2011, Cell metabolism.
[19] B. Yang,et al. Exogenous cell-permeable C6 ceramide sensitizes multiple cancer cell lines to Doxorubicin-induced apoptosis by promoting AMPK activation and mTORC1 inhibition , 2010, Oncogene.
[20] C. Freeman,et al. Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes , 2010, Nature Genetics.
[21] R. Parakhia,et al. Metformin Activates AMP Kinase through Inhibition of AMP Deaminase , 2010, The Journal of Biological Chemistry.
[22] B. Kemp,et al. β-Subunit myristoylation is the gatekeeper for initiating metabolic stress sensing by AMP-activated protein kinase (AMPK) , 2010, Proceedings of the National Academy of Sciences.
[23] R. Bristow,et al. Ionizing radiation activates AMP-activated kinase (AMPK): a target for radiosensitization of human cancer cells. , 2010, International journal of radiation oncology, biology, physics.
[24] E. Abraham,et al. Exposure to Hydrogen Peroxide Induces Oxidation and Activation of AMP-activated Protein Kinase* , 2010, The Journal of Biological Chemistry.
[25] Ricardo Lage,et al. Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance , 2010, Nature Medicine.
[26] Tzong-Der Way,et al. Hispidulin potently inhibits human glioblastoma multiforme cells through activation of AMP-activated protein kinase (AMPK). , 2010, Journal of agricultural and food chemistry.
[27] Simon B. Laughlin,et al. Action Potential Energy Efficiency Varies Among Neuron Types in Vertebrates and Invertebrates , 2010, PLoS Comput. Biol..
[28] B. Viollet,et al. Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state. , 2010, The Journal of clinical investigation.
[29] S. Hawley,et al. Use of Cells Expressing γ Subunit Variants to Identify Diverse Mechanisms of AMPK Activation , 2010, Cell metabolism.
[30] S. Gygi,et al. Network organization of the human autophagy system , 2010, Nature.
[31] G. Chrousos,et al. Interactions of the circadian CLOCK system and the HPA axis , 2010, Trends in Endocrinology & Metabolism.
[32] J. Auwerx,et al. Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle. , 2010, Cell metabolism.
[33] G. Mills,et al. ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS , 2010, Proceedings of the National Academy of Sciences.
[34] M. Driscoll,et al. Metformin Induces a Dietary Restriction–Like State and the Oxidative Stress Response to Extend C. elegans Healthspan via AMPK, LKB1, and SKN-1 , 2010, PloS one.
[35] S. Sternson,et al. AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training , 2010, Nature Neuroscience.
[36] D. Hardie,et al. Calmodulin-dependent protein kinase kinase-β activates AMPK without forming a stable complex: synergistic effects of Ca2+ and AMP , 2009, The Biochemical journal.
[37] K. P. Wong,et al. Uncoupling of oxidative phosphorylation by curcumin: implication of its cellular mechanism of action. , 2009, Biochemical and biophysical research communications.
[38] I. Grummt,et al. AMP-activated protein kinase adapts rRNA synthesis to cellular energy supply , 2009, Proceedings of the National Academy of Sciences.
[39] S. Panda,et al. AMPK Regulates the Circadian Clock by Cryptochrome Phosphorylation and Degradation , 2009, Science.
[40] D. Hardie,et al. Genetic disruption of AMPK signaling abolishes both contraction- and insulin-stimulated TBC1D1 phosphorylation and 14-3-3 binding in mouse skeletal muscle. , 2009, American journal of physiology. Endocrinology and metabolism.
[41] J. Menéndez,et al. The active form of the metabolic sensor AMP-activated protein kinase α (AMPKα) directly binds the mitotic apparatus and travels from centrosomes to the spindle midzone during mitosis and cytokinesis , 2009, Cell cycle.
[42] Zhi-Xin Wang,et al. Structural insight into the autoinhibition mechanism of AMP-activated protein kinase , 2009, Nature.
[43] E. Greer,et al. Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans , 2009, Aging cell.
[44] B. Viollet,et al. Crucial role for LKB1 to AMPKalpha2 axis in the regulation of CD36-mediated long-chain fatty acid uptake into cardiomyocytes. , 2009, Biochimica et biophysica acta.
[45] D. Hardie,et al. Potential role of TBC1D4 in enhanced post-exercise insulin action in human skeletal muscle , 2009, Diabetologia.
[46] C. Brenner,et al. Faculty Opinions recommendation of AMPK and PPARdelta agonists are exercise mimetics. , 2008 .
[47] Maria M. Mihaylova,et al. AMPK and PPARδ Agonists Are Exercise Mimetics , 2008, Cell.
[48] K. Sakamoto,et al. Emerging role for AS160/TBC1D4 and TBC1D1 in the regulation of GLUT4 traffic. , 2008, American journal of physiology. Endocrinology and metabolism.
[49] A. Means,et al. Hypothalamic CaMKK2 contributes to the regulation of energy balance. , 2008, Cell metabolism.
[50] B. Turk,et al. AMPK phosphorylation of raptor mediates a metabolic checkpoint. , 2008, Molecular cell.
[51] Leroy F. Liu,et al. Etoposide Induces ATM-Dependent Mitochondrial Biogenesis through AMPK Activation , 2008, PloS one.
[52] Haiying Cheng,et al. Key Role for AMP-Activated Protein Kinase in the Ventromedial Hypothalamus in Regulating Counterregulatory Hormone Responses to Acute Hypoglycemia , 2008, Diabetes.
[53] D. Campbell,et al. Complementary regulation of TBC1D1 and AS160 by growth factors, insulin and AMPK activators. , 2008, The Biochemical journal.
[54] L. Shapiro,et al. Structural insight into AMPK regulation: ADP comes into play. , 2007, Structure.
[55] D. Hardie,et al. Regulation of multisite phosphorylation and 14-3-3 binding of AS160 in response to IGF-1, EGF, PMA and AICAR. , 2007, The Biochemical journal.
[56] S. Gygi,et al. The Energy Sensor AMP-activated Protein Kinase Directly Regulates the Mammalian FOXO3 Transcription Factor* , 2007, Journal of Biological Chemistry.
[57] S. Gygi,et al. An AMPK-FOXO Pathway Mediates Longevity Induced by a Novel Method of Dietary Restriction in C. elegans , 2007, Current Biology.
[58] D. Hardie,et al. AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy , 2007, Nature Reviews Molecular Cell Biology.
[59] Liang Tong,et al. Crystal structure of the heterotrimer core of Saccharomyces cerevisiae AMPK homologue SNF1 , 2007, Nature.
[60] David Carling,et al. Structural basis for AMP binding to mammalian AMP-activated protein kinase , 2007, Nature.
[61] G. Barsh,et al. AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons. , 2007, The Journal of clinical investigation.
[62] B. Spiegelman,et al. AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α , 2007, Proceedings of the National Academy of Sciences.
[63] Kohjiro Ueki,et al. Adiponectin stimulates AMP-activated protein kinase in the hypothalamus and increases food intake. , 2007, Cell metabolism.
[64] Jun Hee Lee,et al. Energy-dependent regulation of cell structure by AMP-activated protein kinase , 2007, Nature.
[65] Lawrence Shapiro,et al. Crystal Structures of the Adenylate Sensor from Fission Yeast AMP-Activated Protein Kinase , 2007, Science.
[66] Gordon B. Mills,et al. The energy sensing LKB1–AMPK pathway regulates p27kip1 phosphorylation mediating the decision to enter autophagy or apoptosis , 2007, Nature Cell Biology.
[67] Tao Pang,et al. Conserved α-Helix Acts as Autoinhibitory Sequence in AMP-activated Protein Kinase α Subunits* , 2007, Journal of Biological Chemistry.
[68] P. Puigserver,et al. Resveratrol improves health and survival of mice on a high-calorie diet , 2006, Nature.
[69] Uwe Riek,et al. Dissecting the Role of 5′-AMP for Allosteric Stimulation, Activation, and Deactivation of AMP-activated Protein Kinase* , 2006, Journal of Biological Chemistry.
[70] D. James,et al. Berberine, a Natural Plant Product, Activates AMP-Activated Protein Kinase With Beneficial Metabolic Effects in Diabetic and Insulin-Resistant States , 2006, Diabetes.
[71] A. Ashworth,et al. Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPKalpha2 but not AMPKalpha1. , 2006, American journal of physiology. Endocrinology and metabolism.
[72] J. Ha,et al. Genistein, EGCG, and capsaicin inhibit adipocyte differentiation process via activating AMP-activated protein kinase. , 2005, Biochemical and biophysical research communications.
[73] J. Eggermont,et al. CBS domains: structure, function, and pathology in human proteins. , 2005, American journal of physiology. Cell physiology.
[74] M. Montminy,et al. The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism , 2005, Nature.
[75] J. Trimmer,et al. Kv2.1: a voltage-gated k+ channel critical to dynamic control of neuronal excitability. , 2005, Neurotoxicology.
[76] A. Means,et al. The Ca2+/Calmodulin-dependent Protein Kinase Kinases Are AMP-activated Protein Kinase Kinases* , 2005, Journal of Biological Chemistry.
[77] D. Hardie,et al. Cannabinoids and Ghrelin Have Both Central and Peripheral Metabolic and Cardiac Effects via AMP-activated Protein Kinase* , 2005, Journal of Biological Chemistry.
[78] A. Edelman,et al. Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase. , 2005, Cell metabolism.
[79] R. Heath,et al. Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells. , 2005, Cell metabolism.
[80] Christoph Handschin,et al. Metabolic control through the PGC-1 family of transcription coactivators. , 2005, Cell metabolism.
[81] Kei Sakamoto,et al. Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction , 2005, The EMBO journal.
[82] Russell G. Jones,et al. AMP-activated protein kinase induces a p53-dependent metabolic checkpoint. , 2005, Molecular cell.
[83] B. Viollet,et al. The alpha2-5'AMP-activated protein kinase is a site 2 glycogen synthase kinase in skeletal muscle and is responsive to glucose loading. , 2004, Diabetes.
[84] M. Birnbaum,et al. AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus , 2004, Nature.
[85] D. Carling,et al. AMP-activated Protein Kinase Plays a Role in the Control of Food Intake* , 2004, Journal of Biological Chemistry.
[86] B. Kemp. Bateman domains and adenosine derivatives form a binding contract. , 2004, The Journal of clinical investigation.
[87] D. Hardie,et al. CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations. , 2004, The Journal of clinical investigation.
[88] Peter Schjerling,et al. Knockout of the α2 but Not α1 5′-AMP-activated Protein Kinase Isoform Abolishes 5-Aminoimidazole-4-carboxamide-1-β-4-ribofuranosidebut Not Contraction-induced Glucose Uptake in Skeletal Muscle* , 2004, Journal of Biological Chemistry.
[89] K. Inoki,et al. TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival , 2003, Cell.
[90] Jérôme Boudeau,et al. Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade , 2003, Journal of biology.
[91] J. James,et al. A Novel Domain in AMP-Activated Protein Kinase Causes Glycogen Storage Bodies Similar to Those Seen in Hereditary Cardiac Arrhythmias , 2003, Current Biology.
[92] B. Kemp,et al. AMPK β Subunit Targets Metabolic Stress Sensing to Glycogen , 2003, Current Biology.
[93] C. Smythe,et al. Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366. , 2002, The Biochemical journal.
[94] L. Bertrand,et al. The Stimulation of Glycolysis by Hypoxia in Activated Monocytes Is Mediated by AMP-activated Protein Kinase and Inducible 6-Phosphofructo-2-kinase* , 2002, The Journal of Biological Chemistry.
[95] David Carling,et al. The Anti-diabetic Drugs Rosiglitazone and Metformin Stimulate AMP-activated Protein Kinase through Distinct Signaling Pathways* , 2002, The Journal of Biological Chemistry.
[96] David Carling,et al. Activation of GLUT1 by metabolic and osmotic stress: potential involvement of AMP-activated protein kinase (AMPK). , 2002, Journal of cell science.
[97] D. Hardie,et al. Protein kinase substrate recognition studied using the recombinant catalytic domain of AMP-activated protein kinase and a model substrate. , 2002, Journal of molecular biology.
[98] Margaret S. Wu,et al. Role of AMP-activated protein kinase in mechanism of metformin action. , 2001, The Journal of clinical investigation.
[99] S. Laughlin,et al. An Energy Budget for Signaling in the Grey Matter of the Brain , 2001, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
[100] M. Kaminishi,et al. Cell cycle regulation via p53 phosphorylation by a 5'-AMP activated protein kinase activator, 5-aminoimidazole- 4-carboxamide-1-beta-D-ribofuranoside, in a human hepatocellular carcinoma cell line. , 2001, Biochemical and biophysical research communications.
[101] B. Wisse,et al. A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. , 2001, Diabetes.
[102] D. Carling,et al. Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemia , 2000, Current Biology.
[103] W. Winder,et al. Activation of AMP-activated protein kinase increases mitochondrial enzymes in skeletal muscle. , 2000, Journal of applied physiology.
[104] D. Hardie,et al. Regulation of spinach SNF1-related (SnRK1) kinases by protein kinases and phosphatases is associated with phosphorylation of the T loop and is regulated by 5'-AMP. , 1999, The Plant journal : for cell and molecular biology.
[105] R. Coleman,et al. AMP-activated kinase reciprocally regulates triacylglycerol synthesis and fatty acid oxidation in liver and muscle: evidence that sn-glycerol-3-phosphate acyltransferase is a novel target. , 1999, The Biochemical journal.
[106] D. Hardie,et al. AMP-activated protein kinase is activated by low glucose in cell lines derived from pancreatic beta cells, and may regulate insulin release. , 1998, The Biochemical journal.
[107] D. Hardie,et al. AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle. , 1997, American journal of physiology. Endocrinology and metabolism.
[108] D. Hardie,et al. Glucose repression/derepression in budding yeast: SNF1 protein kinase is activated by phosphorylation under derepressing conditions, and this correlates with a high AMP:ATP ratio , 1996, Current Biology.
[109] S. Hawley,et al. Characterization of the AMP-activated Protein Kinase Kinase from Rat Liver and Identification of Threonine 172 as the Major Site at Which It Phosphorylates AMP-activated Protein Kinase* , 1996, The Journal of Biological Chemistry.
[110] D. Hardie,et al. Inactivation of acetyl-CoA carboxylase and activation of AMP-activated protein kinase in muscle during exercise. , 1996, The American journal of physiology.
[111] D. Hardie,et al. 5′‐AMP inhibits dephosphorylation, as well as promoting phosphorylation, of the AMP‐activated protein kinase. Studies using bacterially expressed human protein phosphatase‐2Cα and native bovine protein phosphatase‐2Ac , 1995, FEBS letters.
[112] L. Riechmann,et al. An antibody VH domain with a lox‐Cre site integrated into its coding region: bacterial recombination within a single polypeptide chain , 1995, FEBS letters.
[113] A. Edelman,et al. 5′-AMP Activates the AMP-activated Protein Kinase Cascade, and Ca2+/Calmodulin Activates the Calmodulin-dependent Protein Kinase I Cascade, via Three Independent Mechanisms (*) , 1995, The Journal of Biological Chemistry.
[114] A. Edelman,et al. Similar substrate recognition motifs for mammalian AMP‐activated protein kinase, higher plant HMG‐CoA reductase kinase‐A, yeast SNF1, and mammalian calmodulin‐dependent protein kinase I , 1995, FEBS letters.
[115] D. Hardie,et al. Role of the AMP-activated protein kinase in the cellular stress response , 1994, Current Biology.
[116] D. Hardie,et al. Evidence for a protein kinase cascade in higher plants. 3-Hydroxy-3-methylglutaryl-CoA reductase kinase. , 1992, European journal of biochemistry.
[117] D. Hardie,et al. Diurnal rhythm of phosphorylation of rat liver acetyl-CoA carboxylase by the AMP-activated protein kinase, demonstrated using freeze-clamping. Effects of high fat diets. , 1992, European journal of biochemistry.
[118] D. Hardie,et al. Regulation of HMG‐CoA reductase: identification of the site phosphorylated by the AMP‐activated protein kinase in vitro and in intact rat liver. , 1990, The EMBO journal.
[119] T. Paull,et al. The ATM protein kinase and cellular redox signaling: beyond the DNA damage response. , 2012, Trends in biochemical sciences.
[120] F. Ross,et al. Use of Cells Expressing gamma Subunit Variants to Identify Diverse Mechanisms of AMPK Activation , 2010 .
[121] Anindya Dutta,et al. Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPK 2 but not AMPK 1 , 2006 .
[122] Richard J. Shaw. Inaugural Article: The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress , 2004 .
[123] B. Viollet,et al. Knockout of the alpha2 but not alpha1 5'-AMP-activated protein kinase isoform abolishes 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranosidebut not contraction-induced glucose uptake in skeletal muscle. , 2004, The Journal of biological chemistry.
[124] M. Carlson,et al. Supplemental Data LKB 1 Is the Upstream Kinase in the AMP-Activated Protein Kinase Cascade , 2003 .
[125] B. Viollet,et al. The AMP-activated protein kinase alpha2 catalytic subunit controls whole-body insulin sensitivity. , 2003, The Journal of clinical investigation.
[126] R. Lamuela-Raventós,et al. Method for the quantitative extraction of resveratrol and piceid isomers in grape berry skins. Effect of powdery mildew on the stilbene content. , 2001, Journal of agricultural and food chemistry.
[127] A. Bateman. The structure of a domain common to archaebacteria and the homocystinuria disease protein. , 1997, Trends in biochemical sciences.