Phthalate Plasticizers in Children’s Products and Estimation of Exposure: Importance of Migration Rate

Plasticizers are added to diverse consumer products including children’s products. Owing to their potential for endocrine disruption, the use of phthalate plasticizers is restricted in many children’s products. In this study, exposure to five phthalate esters (dibutylphthalate, di(2-ethylhexyl) phthalate (DEHP), diethyl phthalate, di-isobutyl phthalate, and diisononyl phthalate (DINP)) and an alternative (di-ethylhexyl adipate) was assessed by the use of children’s products based on chemical analysis of 3345 products purchased during 2017 and 2019 in Korea. Plasticizers were found above the detection limits in 387 products, and DEHP and DINP were the two most predominantly detected plasticizers. Deterministic and probabilistic estimation of the margin of exposure at a screening level revealed that the use of children’s products might be an important risk factor. However, it is also highly likely that the exposure could be overestimated, because the migration rate was estimated based solely on the content of plasticizers in children’s products. Chemical migration is a key process determining the absorption of plasticizers from products; thus, further refinements in experimental determination or model estimation of the migration rate are required.

[1]  R. Pittle,et al.  The Consumer Product Safety Commission , 1976 .

[2]  P Grasso,et al.  Short-term oral toxicity study of diethyl phthalate in the rat. , 1978, Food and Cosmetics Toxicology.

[3]  N. Humphrey,et al.  U.S. Consumer Product Safety Commission. , 1990, Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & Practitioners.

[4]  K M Thompson,et al.  Monte Carlo techniques for quantitative uncertainty analysis in public health risk assessments. , 1992, Risk analysis : an official publication of the Society for Risk Analysis.

[5]  A. Renwick.  Data-derived safety factors for the evaluation of food additives and environmental contaminants. , 1993, Food additives and contaminants.

[6]  K. S. Subramanian,et al.  Analysis of diisononyl phthalate in PVC consumer products used by children , 1999 .

[7]  J. Siddorn,et al.  Concentrations of phthalate esters and identification of other additives in PVC children’s toys , 2000, Environmental science and pollution research international.

[8]  K. Bouma,et al.  Migration of phthalates from PVC toys into saliva simulant by dynamic extraction , 2002, Food additives and contaminants.

[9]  D. Letinski,et al.  Slow-stir water solubility measurements of selected alcohols and diesters. , 2002, Chemosphere.

[10]  M. Hirose,et al.  Diverse developmental toxicity of di-n-butyl phthalate in both sexes of rat offspring after maternal exposure during the period from late gestation through lactation. , 2004, Toxicology.

[11]  Hanawa Takehisa,et al.  Release behavior of diethylhexyl phthalate from the polyvinyl-chloride tubing used for intravenous administration and the plasticized PVC membrane. , 2005, International journal of pharmaceutics.

[12]  W. Belzer.  Submitted to Texas State Soil and Water Conservation Board (TSSWCB) U.S. Environmental Protection Agency (EPA) , 2007 .

[13]  A. Saillenfait,et al.  Diisobutyl phthalate impairs the androgen-dependent reproductive development of the male rat. , 2008, Reproductive toxicology.

[14]  Mutsuko Hirata-Koizumi,et al.  Potential adverse effects of phthalic acid esters on human health: a review of recent studies on reproduction. , 2008, Regulatory toxicology and pharmacology : RTP.

[15]  Elaine A Cohen Hubal,et al.  Predicting residential exposure to phthalate plasticizer emitted from vinyl flooring: a mechanistic analysis. , 2009, Environmental science & technology.

[16]  Michael A. Kamrin,et al.  Phthalate Risks, Phthalate Regulation, and Public Health: A Review , 2009, Journal of toxicology and environmental health. Part B, Critical reviews.

[17]  K. Ting,et al.  GC/MS screening method for phthalate esters in children's toys. , 2009, Journal of AOAC International.

[18]  A. Kortenkamp,et al.  Synergistic Disruption of External Male Sex Organ Development by a Mixture of Four Antiandrogens , 2009, Environmental health perspectives.

[19]  R. Whyatt,et al.  A review of alternatives to di (2-ethylhexyl) phthalate-containing medical devices in the neonatal intensive care unit , 2011, Journal of Perinatology.

[20]  M. A. Mohd,et al.  Occurrence of phthalate metabolites in human urine from several Asian countries. , 2011, Environmental science & technology.

[21]  Charles J. Weschler,et al.  Predicting dermal absorption of gas-phase chemicals: transient model development, evaluation, and application. , 2014, Indoor air.

[22]  Kyungho Choi,et al.  Urinary phthalate metabolites among elementary school children of Korea: sources, risks, and their association with oxidative stress marker. , 2014, The Science of the total environment.

[23]  Philip E Mirkes,et al.  Assessment of phthalates/phthalate alternatives in children’s toys and childcare articles: Review of the report including conclusions and recommendation of the Chronic Hazard Advisory Panel of the Consumer Product Safety Commission , 2015, Journal of Exposure Science and Environmental Epidemiology.

[24]  Kyungho Choi,et al.  Migration of DEHP and DINP into dust from PVC flooring products at different surface temperature. , 2016, The Science of the total environment.

[25]  John C. Little,et al.  Phthalates and alternative plasticizers and potential for contact exposure from children’s backpacks and toys , 2016, Journal of Exposure Science and Environmental Epidemiology.

[26]  H. Chiang,et al.  Estimated Daily Intake and Cumulative Risk Assessment of Phthalates in the General Taiwanese after the 2011 DEHP Food Scandal , 2017, Scientific Reports.

[27]  Katy O Goyak,et al.  A quantitative screening‐level approach to incorporate chemical exposure and risk into alternative assessment evaluations , 2017, Integrated environmental assessment and management.

[28]  E. Papadopoulou,et al.  Multi-pathway human exposure assessment of phthalate esters and DINCH. , 2018, Environment international.

[29]  M. Sadeh,et al.  Concentrations of trace metals, phthalates, bisphenol A and flame-retardants in toys and other children's products in Israel. , 2018, Chemosphere.

[30]  Dawen Gao,et al.  An overview of phthalate acid ester pollution in China over the last decade: Environmental occurrence and human exposure. , 2018, The Science of the total environment.

[31]  T. Brüning,et al.  Metabolism and urinary excretion kinetics of di(2-ethylhexyl) adipate (DEHA) in four human volunteers after a single oral dose. , 2019, Toxicology letters.

[32]  Yuan Kang,et al.  Dermal bioaccessibility of plasticizers in indoor dust and clothing. , 2019, The Science of the total environment.

[33]  K. Kannan,et al.  A Review of Biomonitoring of Phthalate Exposures , 2019, Toxics.

[34]  M. A. Dreyfus,et al.  Plasticizer migration from children's toys, child care articles, art materials, and school supplies. , 2020, Regulatory toxicology and pharmacology : RTP.

[35]  T. Kawakami,et al.  Skin transferability of phthalic acid ester plasticizers and other plasticizers using model polyvinyl chloride sheets , 2020, Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering.

[36]  Mohammed D Y Oteef,et al.  Plastic toys and child care articles as a source of children exposure to phthalates and other plasticisers in Saudi Arabia , 2020, International Journal of Environmental Analytical Chemistry.