Loss of cerebellar Purkinje cells in aged mice homozygous for a disrupted PrP gene

[1]  H. Sato,et al.  Accumulation of proteinase K-resistant prion protein (PrP) is restricted by the expression level of normal PrP in mice inoculated with a mouse-adapted strain of the Creutzfeldt-Jakob disease agent , 1995, Journal of virology.

[2]  M. Palmer,et al.  Rescue of neurophysiological phenotype seen in PrP null mice by transgene encoding human prion protein , 1995, Nature Genetics.

[3]  I. Mcconnell,et al.  PrP gene dosage determines the timing but not the final intensity or distribution of lesions in scrapie pathology. , 1994, Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration.

[4]  A. Aguzzi,et al.  High Prion and PrPSc Levels but Delayed Onset of Disease in Scrapie-Inoculated Mice Heterozygous for a Disrupted PrP Gene , 1994, Molecular medicine.

[5]  M. Palmer,et al.  Prion protein is necessary for normal synaptic function , 1994, Nature.

[6]  S. Prusiner,et al.  Ablation of the prion protein (PrP) gene in mice prevents scrapie and facilitates production of anti-PrP antibodies. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[7]  A. Aguzzi,et al.  Mice devoid of PrP are resistant to scrapie , 1993, Cell.

[8]  G. Forloni,et al.  Neurotoxicity of a prion protein fragment , 1993, Nature.

[9]  Rudolf Jaenisch,et al.  Targeted mutation of the DNA methyltransferase gene results in embryonic lethality , 1992, Cell.

[10]  S. Prusiner,et al.  Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein , 1992, Nature.

[11]  Andrew P. McMahon,et al.  The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain , 1990, Cell.

[12]  M. Mattson.  Antigenic changes similar to those seen in neurofibrillary tangles are elicited by glutamate and Ca2+ influx in cultured hippocampal neurons , 1990, Neuron.

[13]  S. Prusiner,et al.  Changes in the localization of brain prion proteins during scrapie infection , 1987, Neurology.

[14]  S. Prusiner.  Biology and genetics of prion diseases. , 1994, Annual review of microbiology.