Green Extraction: From Concepts to Research, Education, and Economical Opportunities

One of the principal aims of sustainable development of green processing is in the teaching of green chemistry in colleges, high schools, and academic laboratories of both developed and developing nations. The researchers from academia and professionals from industry have chosen not to ignore the potential consequences of green chemistry and processes and have realized that they have responsibilities in education, research, and acceptance for industrial implementation of green chemistry (analysis, extraction, synthesis, separation, etc.) [1].They recognize that their research will affect the future of the planet with the creation of new products and processes that improve the quality of life and reduce environmental hazards [2–4]. The implementation of green chemistry technologies minimizes the use of materials that are hazardous to human health and environment [5], decreases energy and water usage, and maximizes efficiency (Figure 1.1). Extraction of natural products has been used probably since the discovery of fire. Egyptians and Phoenicians, Jews and Arabs, Indians and Chinese, Greeks and Romans, and even theMayans andAztecs, all possessed innovative extraction processes (maceration, alembic distillation, etc.) used even for perfume, medicine, or food. However, during the 1990s, it was not easy to find literature concerning the dispersed efforts for greening the extraction practices. It was necessary to wait for the tremendous development of green chemistry made by the Environmental Protection Agency (EPA) and led by Paul Anastas [3], who published a series of fundamental books from 1994 trying to create a general conscience on the need for green chemistry. Recent trends in extraction techniques have largely focused on finding solutions that minimize the use of solvent and energy, such as supercritical fluid extraction, ultrasound extraction, subcritical water extraction, controlled pressure drop process, pulse electric field, and microwave extraction. The tremendous efforts made in greening extraction processes can be evaluated through the consideration of books devoted to these aspects as can be seen in Figure 1.2.Theoretical and

[1]  M. Clifford,et al.  Dietary phenolics: chemistry, bioavailability and effects on health. , 2009, Natural product reports.

[2]  J. Simon,et al.  Effects of osmotic stress on the essential oil content and composition of peppermint. , 1990 .

[3]  S. Chevalley,et al.  Quassinoid constituents of Quassia amara L. leaf herbal tea. Impact on its antimalarial activity and cytotoxicity. , 2009, Journal of ethnopharmacology.

[4]  K. Srinivasan,et al.  Black Pepper and its Pungent Principle-Piperine: A Review of Diverse Physiological Effects , 2007, Critical reviews in food science and nutrition.

[5]  Xian-guo He,et al.  On-line identification of phytochemical constituents in botanical extracts by combined high-performance liquid chromatographic-diode array detection-mass spectrometric techniques. , 2000, Journal of chromatography. A.

[6]  P. Anastas,et al.  Green Chemistry , 2018, Environmental Science.

[7]  R. Peralta,et al.  Phenolic compounds in fruits – an overview , 2012 .

[8]  Farid Chemat,et al.  Microwave accelerated steam distillation of essential oil from lavender: A rapid, clean and environmentally friendly approach , 2006 .

[9]  P. Jones,et al.  Phytosterols as functional food ingredients: linkages to cardiovascular disease and cancer , 2009, Current opinion in clinical nutrition and metabolic care.

[10]  R. Poppi,et al.  Classification of Amazonian rosewood essential oil by Raman spectroscopy and PLS-DA with reliability estimation. , 2013, Talanta.

[11]  F. Chemat,et al.  Portable microwave assisted extraction: An original concept for green analytical chemistry. , 2013, Journal of chromatography. A.

[12]  Gillian McMahon Analytical Instrumentation: A Guide to Laboratory, Portable and Miniaturized Instruments , 2007 .

[13]  J. Michael Indolizidine and quinolizidine alkaloids. , 2010, Natural product reports.

[14]  J. German,et al.  Phytochemicals: nutraceuticals and human health , 2000 .

[15]  V. Preedy Caffeine : chemistry, analysis, function and effects , 2012 .

[16]  M. Goto,et al.  Extraction of Ginger Oil with Supercritical Carbon Dioxide: Experiments and Modeling , 1996 .

[17]  P. Halley,et al.  Macromolecular Interactions During Gelatinisation and Retrogradation in Starch-Whey Systems as Studied by Rapid Visco-Analyser , 2006 .

[18]  R. Carle,et al.  Identification of flavonol and xanthone glycosides from mango (Mangifera indica L. Cv. "Tommy Atkins") peels by high-performance liquid chromatography-electrospray ionization mass spectrometry. , 2003, Journal of agricultural and food chemistry.

[19]  K. Rezzadori,et al.  Proposals for the residues recovery: Orange waste as raw material for new products , 2012 .

[20]  J. Kühnau The flavonoids. A class of semi-essential food components: their role in human nutrition. , 1976, World review of nutrition and dietetics.

[21]  Laura R. Emery,et al.  Protein Phylogenetic Analysis of Ca2+/cation Antiporters and Insights into their Evolution in Plants , 2012, Front. Plant Sci..

[22]  Farid Chemat,et al.  A new process for extraction of essential oil from Citrus peels: microwave hydrodiffusion and gravity. , 2009 .

[23]  F. Chemat,et al.  Techniques for Oil Extraction , 2010 .

[24]  C. Ibeto,et al.  Preliminary Studies on the Characterization of Orange Seed and Pawpaw Seed Oils , 2011 .

[25]  S. Wise,et al.  Determination of bitter orange alkaloids in dietary supplement Standard Reference Materials by liquid chromatography with atmospheric-pressure ionization mass spectrometry , 2007, Analytical and bioanalytical chemistry.

[26]  P. Ollitrault,et al.  Carotenoid diversity in cultivated citrus is highly influenced by genetic factors. , 2006, Journal of agricultural and food chemistry.

[27]  M. Scotter The chemistry and analysis of annatto food colouring: a review , 2009 .

[28]  O. Martín‐Belloso,et al.  Comparative content of total polyphenols and dietary fiber in tropical fruits and persimmon. , 1999, The Journal of nutritional biochemistry.

[29]  Md. Mokhlesur Rahman,et al.  Techniques for extraction of bioactive compounds from plant materials: A review , 2013 .

[30]  Celestino Santos-Buelga,et al.  Proanthocyanidins and tannin‐like compounds – nature, occurrence, dietary intake and effects on nutrition and health , 2000 .

[31]  Masayoshi Sawamura,et al.  Volatile constituents of Vietnamese pummelo, orange, tangerine and lime peel oils , 2002 .

[32]  P. Jamuna,et al.  Bioactive components of garlic and their physiological role in health maintenance: A review , 2013 .

[33]  F. Chemat,et al.  “In situ” extraction of essential oils by use of Dean–Stark glassware and a Vigreux column inside a microwave oven: a procedure for teaching green analytical chemistry , 2012, Analytical and Bioanalytical Chemistry.

[34]  C. F. Timberlake,et al.  Anthocyanins as natural food colours—selected aspects , 1997 .

[35]  G. Cordell Fifty years of alkaloid biosynthesis in Phytochemistry. , 2013, Phytochemistry.

[36]  A. D'yakonov,et al.  Quinazoline alkaloids in nature , 1997, Chemistry of Natural Compounds.

[37]  Yong Sup Lee,et al.  An update on bioactive plant lignans. , 2005, Natural product reports.

[38]  T. Demura,et al.  Regulation of plant biomass production. , 2010, Current opinion in plant biology.

[39]  K. Saeb,et al.  Variation of essential oil composition of Melissa officinalis L. leaves during different stages of plant growth , 2012 .

[40]  Federico Ferreres,et al.  Characterisation of polyphenols and antioxidant properties of five lettuce varieties and escarole. , 2008, Food chemistry.

[41]  S. Benvenuti,et al.  Chromatographic and electrophoretic methods for the analysis of phenetylamine alkaloids in Citrus aurantium , 2007 .

[42]  N. Jorge,et al.  Physico-chemical Characterization of Seed Oils Extracted from Oranges (Citrus sinensis) , 2013 .

[43]  C. Hasler,et al.  Position of the American Dietetic Association: functional foods. , 1999, Journal of the American Dietetic Association.

[44]  G. Williamson,et al.  Dietary intake and bioavailability of polyphenols. , 2000, The Journal of nutrition.

[45]  O. Paredes-López,et al.  Natural Pigments: Carotenoids, Anthocyanins, and Betalains — Characteristics, Biosynthesis, Processing, and Stability , 2000, Critical reviews in food science and nutrition.

[46]  I. C. Simoni,et al.  Flavonol monoglycosides isolated from the antiviral fractions of Persea americana (Lauraceae) leaf infusion , 1998 .

[47]  P. Dugo,et al.  Characterization of 12 Capsicum varieties by evaluation of their carotenoid profile and pungency determination. , 2013, Food chemistry.

[48]  A. Roy,et al.  Limonoids: overview of significant bioactive triterpenes distributed in plants kingdom. , 2006, Biological & pharmaceutical bulletin.

[49]  P. Dewick,et al.  Medicinal Natural Products: A Biosynthetic Approach , 1997 .

[50]  M. G. Warner,et al.  Solventless syntheses of mesotetraphenylporphyrin: newexperiments for a greener organic chemistry laboratory curriculum , 2001 .

[51]  O. Dangles,et al.  A comprehensive review on flavanones, the major citrus polyphenols , 2014 .

[52]  F. Chemat,et al.  An improved microwave Clevenger apparatus for distillation of essential oils from orange peel. , 2006, Journal of chromatography. A.

[53]  Fanica Mustata,et al.  Cellulose extraction from orange peel using sulfite digestion reagents. , 2011, Bioresource technology.

[54]  M. Levey EVIDENCES OF ANCIENT DISTILLATION, SUBLIMATION AND EXTRACTION IN MESOPOTAMIA , 1955 .

[55]  Om V. Singh,et al.  Bioconversion of Lignocellulosic Biomass: Biochemical and Molecular Perspectives , 2009 .

[56]  Angela Maurizi,et al.  Characterisation of secondary metabolites in saffron from central Italy (Cascia, Umbria). , 2014, Food chemistry.

[57]  H. Shah,et al.  DETERMINATION OF BETA CAROTENE CONTENT IN FRESH VEGETABLES USING HIGH PERFORMANCE LIQUID CHROMATOGRAPHY , 2007 .

[58]  W. Boerjan,et al.  Lignin biosynthesis. , 2003, Annual review of plant biology.

[59]  Richard D. O'Brien,et al.  Fats and oils: formulating and processing for applications. , 1998 .

[60]  D. Rodriguez-Amaya,et al.  Flavonols in fresh and processed Brazilian fruits , 2009 .

[61]  Florian C. Stintzing,et al.  Betalains – emerging prospects for food scientists , 2007 .

[62]  M. Olle Analyse des corps gras , 2002, Techniques d'analyse.

[63]  A. Szajdek,et al.  Bioactive Compounds and Health-Promoting Properties of Berry Fruits: A Review , 2008, Plant foods for human nutrition.

[64]  G. Dugo,et al.  Composition of Egyptian Nerolì Oil , 2011, Natural product communications.

[65]  F. Chemat,et al.  Deodorization by instant controlled pressure drop autovaporization of rosemary leaves prior to solvent extraction of antioxidants , 2013 .

[66]  S. Garrigues,et al.  On-line vapor-phase generation combined with Fourier transform infrared spectrometry , 2008 .

[67]  Kazuki Saito,et al.  Quinolizidine alkaloid biosynthesis: recent advances and future prospects , 2012, Front. Plant Sci..

[68]  Anupam Sharma,et al.  Passiflora: a review update. , 2004, Journal of ethnopharmacology.

[69]  A. Salimi,et al.  Experimental design on supercritical extraction of essential oil from valerian roots and study of optimal conditions , 2010 .

[70]  A. Crozier,et al.  Caffeine and related purine alkaloids: biosynthesis, catabolism, function and genetic engineering. , 2008, Phytochemistry.

[71]  Farooq Anwar,et al.  Valuable Nutrients and Functional Bioactives in Different Parts of Olive (Olea europaea L.)—A Review , 2012, International journal of molecular sciences.

[72]  R. Keast,et al.  Chapter 2:Caffeine as an Ingredient in Sugar Sweetened Beverages , 2012 .

[73]  F. Shahidi NUTRACEUTICALS AND FUNCTIONAL FOODS IN HEALTH PROMOTION AND DISEASE PREVENTION , 2005 .

[74]  W. Kolanowski,et al.  Enrichment of food products with polyunsaturated fatty acids by fish oil addition , 2006 .

[75]  J. Valle,et al.  Matrix effects in supercritical CO2 extraction of essential oils from plant material. , 2009 .

[76]  Jesse A. Contreras,et al.  Hand-portable gas chromatograph-toroidal ion trap mass spectrometer (GC-TMS) for detection of hazardous compounds , 2008, Journal of the American Society for Mass Spectrometry.

[77]  F. Chemat,et al.  Thermal and mechanical intensification of essential oil extraction from orange peel via instant autovaporization , 2013 .

[78]  E. Ibáñez,et al.  Sub- and supercritical fluid extraction of functional ingredients from different natural sources: Plants, food-by-products, algae and microalgae: A review , 2006 .

[79]  G. D. Manners Citrus limonoids: analysis, bioactivity, and biomedical prospects. , 2007, Journal of agricultural and food chemistry.

[80]  T. Miyazawa,et al.  Separation and determination of glycolipids from edible plant sources by high-performance liquid chromatography and evaporative light-scattering detection , 1999, Lipids.

[81]  Manuela Herman,et al.  Biochemistry And Molecular Biology Of Plants , 2016 .

[82]  H. Bart Extraction of natural products from plants - an introduction. , 2011 .

[83]  Marcy J. Balunas,et al.  Xanthones from the botanical dietary supplement mangosteen (Garcinia mangostana) with aromatase inhibitory activity. , 2008, Journal of natural products.

[84]  M. de la Guardia,et al.  Green Analytical Chemistry , 2008 .

[85]  V. Papadimitriou,et al.  Colloidal structures in natural oils , 2010 .

[86]  C. Rice-Evans,et al.  Antioxidant properties of phenolic compounds , 1997 .

[87]  Vasileios Bampidis,et al.  Citrus by-products as ruminant feeds: A review , 2006 .

[88]  Subhash Bhatia,et al.  Feasibility of edible oil vs. non-edible oil vs. waste edible oil as biodiesel feedstock , 2008 .

[89]  T. Beta Chemical and functional properties of food components , 2009 .

[90]  J. Kyle,et al.  Plant polyphenols in cancer and heart disease: implications as nutritional antioxidants , 2000, Nutrition Research Reviews.

[91]  K. Setchell,et al.  Dietary isoflavones: biological effects and relevance to human health. , 1999, The Journal of nutrition.

[92]  Lucie A. Pfaltzgraff,et al.  Food waste biomass: a resource for high-value chemicals , 2013 .

[93]  A. Suksamrarn,et al.  Xanthones from the green fruit hulls of Garcinia mangostana. , 2002, Journal of natural products.

[94]  G. Edwards‐Jones,et al.  Plant metabolites and nutritional quality of vegetables. , 2008, Journal of food science.

[95]  J. Ross,et al.  Dietary flavonoids: bioavailability, metabolic effects, and safety. , 2002, Annual review of nutrition.

[96]  L. Mondello,et al.  Characterization of Oils from the Fruits, Leaves and Flowers of the Bitter Orange Tree , 2011 .

[97]  A. Franke,et al.  Fast HPLC-ECD analysis of ascorbic acid, dehydroascorbic acid and uric acid. , 2009, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[98]  V. Kuete,et al.  Phytotoxic, antifungal activities and acute toxicity studies of the crude extract and compounds from Diospyros canaliculata , 2011, Natural product research.

[99]  P. Barlow,et al.  Quantification of gallic acid and ellagic acid from longan (Dimocarpus longan Lour.) seed and mango (Mangifera indica L.) kernel and their effects on antioxidant activity , 2006 .

[100]  R. Dixon,et al.  Proanthocyanidins--a final frontier in flavonoid research? , 2005, The New phytologist.

[101]  Yanqun Li,et al.  Analysis and evaluation of essential oil components of cinnamon barks using GC–MS and FTIR spectroscopy , 2013 .

[102]  R. N. Cavalcanti,et al.  CHAPTER 1:Uses and Applications of Extracts from Natural Sources , 2013 .

[103]  F. Badria Melatonin, serotonin, and tryptamine in some egyptian food and medicinal plants. , 2002, Journal of medicinal food.

[104]  K. Grohmann,et al.  Purification of citrus peel juice and molasses. , 1999, Journal of agricultural and food chemistry.

[105]  L. Alegre,et al.  Changes in carotenoids, tocopherols and diterpenes during drought and recovery, and the biological significance of chlorophyll loss in Rosmarinus officinalis plants , 2000, Planta.

[106]  U. Wölwer-Rieck The leaves of Stevia rebaudiana (Bertoni), their constituents and the analyses thereof: a review. , 2012, Journal of agricultural and food chemistry.

[107]  Y. Zu,et al.  Microwave irradiation to pretreat rosemary (Rosmarinus officinalis L.) for maintaining antioxidant content during storage and to extract essential oil simultaneously , 2012 .

[108]  Zhong Jin Muscarine, imidazole, oxazole, and thiazole alkaloids. , 2003, Natural product reports.

[109]  V. Dembitsky,et al.  The multiple nutrition properties of some exotic fruits: Biological activity and active metabolites , 2011 .

[110]  Christophe Blecker,et al.  Optimization of pectin extraction from lemon by-product with acidified date juice using response surface methodology , 2008 .

[111]  A. Giovane,et al.  Citrus genus plants contain N-methylated tryptamine derivatives and their 5-hydroxylated forms. , 2013, Journal of Agricultural and Food Chemistry.

[112]  Samir Samman,et al.  Flavonoids—Chemistry, metabolism, cardioprotective effects, and dietary sources , 1996 .

[113]  Florian C. Stintzing,et al.  Functional properties of anthocyanins and betalains in plants, food, and in human nutrition , 2004 .

[114]  R. Stanley,et al.  Extraction of Polyphenolics from Apple Juice by Foam Fractionation , 2006 .

[115]  Norio Miura,et al.  Miniaturized portable surface plasmon resonance immunosensor applicable for on-site detection of low-molecular-weight analytes , 2006 .

[116]  Frank D. Gunstone,et al.  Vegetable Oils in Food Technology: Composition, Properties, and Uses , 2002 .

[117]  A. Kameli,et al.  Essential oil of Algerian rose-scented geranium (Pelargonium graveolens): Chemical composition and antimicrobial activity against food spoilage pathogens , 2013 .

[118]  C. Johnson,et al.  Seasonal variations of rosmarinic and carnosic acids in rosemary extracts. Analysis of their in vitro antiradical activity. , 2005 .

[119]  H. Bart,et al.  Industrial Scale Natural Products Extraction: BART:NAT.PROD.EXTRACTION O-BK , 2011 .

[120]  S. Benvenuti,et al.  Fast high-performance liquid chromatography analysis of phenethylamine alkaloids in Citrus natural products on a pentafluorophenylpropyl stationary phase. , 2007, Journal of chromatography. A.

[121]  M. Meireles,et al.  Supercritical extraction of essential oil from aniseed (Pimpinella anisum L) using CO2: solubility, kinetics, and composition data. , 2003, Journal of agricultural and food chemistry.

[122]  Martin Olazar,et al.  Implementation of industrial health and safety in chemical engineering teaching laboratories , 2006 .

[123]  Farid Chemat,et al.  Green Extraction of Natural Products: Concept and Principles , 2012, International journal of molecular sciences.

[124]  Dermot Brabazon,et al.  Portable capillary-based (non-chip) capillary electrophoresis , 2010 .

[125]  P. Kongsaeree,et al.  An antimalarial stilbene from Artocarpus integer. , 2000, Phytochemistry.

[126]  P. Dewick The biosynthesis of C 5 –C 25 terpenoid compounds , 1999 .