Prophage induction by DNA topoisomerase II poisons and reactive-oxygen species: role of DNA breaks.

[1]  W. Denny,et al.  The genetic toxicology of acridines. , 1991, Mutation research.

[2]  P. Kinney,et al.  Performance of 133 compounds in the lambda prophage induction endpoint of the Microscreen assay and a comparison with S. typhimurium mutagenicity and rodent carcinogenicity assays. , 1991, Mutation research.

[3]  D. DeMarini,et al.  Compatibility of organic solvents with the Microscreen prophage-induction assay: solvent--mutagen interactions. , 1991, Mutation research.

[4]  A. Bernardi,et al.  Introduction of a UV-damaged replicon into a recipient cell is not a sufficient condition to produce an SOS-inducing signal. , 1991, Mutation research.

[5]  D. Bell,et al.  DNA sequence analysis of revertants of the hisD3052 allele of Salmonella typhimurium TA98 using the polymerase chain reaction and direct sequencing: application to 1-nitropyrene-induced revertants. , 1991, Mutation research.

[6]  M. Moore,et al.  Genotoxicity of inhibitors of DNA topoisomerases I (camptothecin) and II (m-AMSA) in vivo and in vitro. , 1990, Mutagenesis.

[7]  N. Oleinick Ionizing radiation damage to DNA: molecular aspects. , 1990, Radiation research.

[8]  P. Jeggo,et al.  DNA double-strand break repair pathways and cellular tolerance to inhibitors of topoisomerase II. , 1990, Cancer research.

[9]  E. Zeiger,et al.  Effects of Salmonella genotypes and testing protocols on H2O2-induced mutation. , 1990, Mutagenesis.

[10]  R. Gupta,et al.  Tests for the genotoxicity of m-AMSA, etoposide, teniposide and ellipticine in Neurospora crassa. , 1990, Mutation research.

[11]  G. Dodin,et al.  Kinetic and thermodynamic studies on drug-DNA interactions in the ellipticine series. , 1990, Anti-cancer drug design.

[12]  M. Hofnung,et al.  Induction of the SOS response by hydrogen peroxide in various Escherichia coli mutants with altered protection against oxidative DNA damage , 1989, Journal of bacteriology.

[13]  M. Hofnung,et al.  Detection of ionizing radiations with the SOS Chromotest, a bacterial short-term test for genotoxic agents. , 1989, Mutation research.

[14]  S. De Flora,et al.  Mutagenicity of active oxygen species in bacteria and its enzymatic or chemical inhibition. , 1989, Mutation research.

[15]  A. Favre,et al.  Induction of sfiA SOS function by peroxides using three different E. coli strains. , 1989, Toxicology letters.

[16]  K. Pienta,et al.  Cancer as a disease of DNA organization and dynamic cell structure. , 1989, Cancer research.

[17]  H. Glatt Mutagenicity spectra in Salmonella typhimurium strains of glutathione, L-cysteine and active oxygen species. , 1989, Mutagenesis.

[18]  S. Linn,et al.  DNA damage and oxygen radical toxicity. , 1988, Science.

[19]  R. Meneghini Genotoxicity of active oxygen species in mammalian cells. , 1988 .

[20]  D. DeMarini,et al.  Hotspot sites for acridine-induced frameshift mutations in bacteriophage T4 correspond to sites of action of the T4 type II topoisomerase. , 1988, Journal of molecular biology.

[21]  A. Kleinhofs,et al.  Metabolic activation of the mutagen azide in biological systems. , 1988, Mutation research.

[22]  T. Shimada,et al.  SOS-inducing activity of chemical carcinogens and mutagens in Salmonella typhimurium TA1535/pSK1002: examination with 151 chemicals. , 1987, Mutation research.

[23]  W. von der Hude,et al.  Evaluation of the SOS chromotest. , 1987, Mutation research.

[24]  M. Moore,et al.  Mutagenicity of actinomycin D in mammalian cells due to clastogenic effects. , 1987, Mutation research.

[25]  M. Gaulden Hypothesis: some mutagens directly alter specific chromosomal proteins (DNA topoisomerase II and peripheral proteins) to produce chromosome stickiness, which causes chromosome aberrations. , 1987, Mutagenesis.

[26]  M. Moore,et al.  Mutagenicity of m-AMSA and o-AMSA in mammalian cells due to clastogenic mechanism: possible role of topoisomerase. , 1987, Mutagenesis.

[27]  D. DeMarini,et al.  Induction of prophage lambda by chlorinated pesticides. , 1987, Mutation research.

[28]  S. Linn,et al.  Mutagenesis and stress responses induced in Escherichia coli by hydrogen peroxide , 1987, Journal of bacteriology.

[29]  M. Moore,et al.  Mutagenicity and clastogenicity of adriamycin in L5178Y/TK(+/-)-3.7.2C mouse lymphoma cells. , 1987, Mutation research.

[30]  J. Wang Recent studies of DNA topoisomerases. , 1987, Biochimica et biophysica acta.

[31]  T. Rossman,et al.  Genetic effects of 5-hydroxymethyl-2'-deoxyuridine, a product of ionizing radiation. , 1987, Mutation research.

[32]  B. Salles,et al.  A bacterial strain for detecting agents that produce free radical-mediated DNA strand breaks. , 1987, Mutation research.

[33]  M. Moore,et al.  Mutagenicity and clastogenicity of teniposide (VM-26) in L5178Y/TK +/- -3.7.2C mouse lymphoma cells. , 1987, Mutation research.

[34]  F. Neidhardt,et al.  Differential induction of heat shock, SOS, and oxidation stress regulons and accumulation of nucleotides in Escherichia coli , 1987, Journal of bacteriology.

[35]  J. Tunac,et al.  The Escherichia coli K-12 SOS chromotest agar spot test for simple, rapid detection of genotoxic agents. , 1986, Mutation research.

[36]  H. H. Evans,et al.  Locus specificity in the mutability of L5178Y mouse lymphoma cells: the role of multilocus lesions. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[37]  S. V. Gupta,et al.  Comparison of the mutagenic activity of 5-hydroxymethyldeoxyuridine with 5-substituted 2'-deoxyuridine analogs in the Ames Salmonella/microsome test. , 1986, Mutation research.

[38]  W. Ross DNA topoisomerases as targets for cancer therapy. , 1985, Biochemical pharmacology.

[39]  H. Shinagawa,et al.  Evaluation of the new system (umu-test) for the detection of environmental mutagens and carcinogens. , 1985, Mutation research.

[40]  A. Collins,et al.  Novobiocin inhibition of DNA excision repair may occur through effects on mitochondrial structure and ATP metabolism, not on repair topoisomerases. , 1985, Carcinogenesis.

[41]  Y. Pommier,et al.  Correlations between intercalator-induced DNA strand breaks and sister chromatid exchanges, mutations, and cytotoxicity in Chinese hamster cells. , 1985, Cancer research.

[42]  M. Hofnung,et al.  The SOS Chromotest, a colorimetric bacterial assay for genotoxins: validation study with 83 compounds. , 1985, Mutation research.

[43]  L. Liu,et al.  Nonintercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II. , 1984, The Journal of biological chemistry.

[44]  L. Liu,et al.  Adriamycin-induced DNA damage mediated by mammalian DNA topoisomerase II. , 1984, Science.

[45]  L. Liu,et al.  Identification of the breakage-reunion subunit of T4 DNA topoisomerase. , 1984, The Journal of biological chemistry.

[46]  B. Ames,et al.  Spontaneous and mutagen-induced deletions: mechanistic studies in Salmonella tester strain TA102. , 1984, Proceedings of the National Academy of Sciences of the United States of America.

[47]  B. Alberts,et al.  Site-specific recognition of bacteriophage T4 DNA by T4 type II DNA topoisomerase and Escherichia coli DNA gyrase. , 1984, The Journal of biological chemistry.

[48]  W. Whong,et al.  Validation of the Salmonella (SV50)/arabinose-resistant forward mutation assay system with 26 compounds. , 1984, Mutation research.

[49]  L. Liu,et al.  Mechanism of antitumor drug action: poisoning of mammalian DNA topoisomerase II on DNA by 4'-(9-acridinylamino)-methanesulfon-m-anisidide. , 1984, Proceedings of the National Academy of Sciences of the United States of America.

[50]  D. DeMarini,et al.  Mutagenicity and cytotoxicity of five antitumor ellipticines in mammalian cells and their structure-activity relationships in Salmonella. , 1983, Cancer research.

[51]  R. White,et al.  Biochemical prophage induction assay: a rapid test for antitumor agents that interact with DNA. , 1983, Cancer research.

[52]  B. Ames,et al.  A new Salmonella tester strain (TA102) with A X T base pairs at the site of mutation detects oxidative mutagens. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[53]  J. Gillard,et al.  Adriamycin analogs. 2. Novel anomeric ribofuranoside analogs of daunorubicin , 1982 .

[54]  T. Sugimura,et al.  Prophage λ induction test (inductest) of anti-tumor antibiotics , 1981 .

[55]  H. Rosenkranz,et al.  Non-mutagenic genotoxicants: novobiocin and nalidixic acid, 2 inhibitors of DNA gyrase. , 1980, Mutation research.

[56]  R. Devoret,et al.  Induction of prophage λ by daunorubicin and derivatives correlation with antineoplastic activity , 1980 .

[57]  R. Gleckman,et al.  Drug therapy reviews: nalidixic acid. , 1979, American journal of hospital pharmacy.

[58]  M. Snyder,et al.  DNA gyrase on the bacterial chromosome: DNA cleavage induced by oxolinic acid. , 1979, Journal of molecular biology.

[59]  W. Denny,et al.  Potential antitumor agents. 30. Mutagenic activity of some 9-anilinoacridines: relationships between structure, mutagenic potential, and antileukemic activity. , 1979, Journal of medicinal chemistry.

[60]  N. Bachur,et al.  NADPH cytochrome P-450 reductase activation of quinone anticancer agents to free radicals. , 1979, Proceedings of the National Academy of Sciences of the United States of America.

[61]  B. Ames,et al.  Mutagenicity of cancer chemotherapeutic agents in the Salmonella/microsome test. , 1977, Cancer research.

[62]  N. Bachur,et al.  Adriamycin and daunorubicin inhibition of mutant T4 DNA polymerases. , 1974, Proceedings of the National Academy of Sciences of the United States of America.

[63]  K. Danø,et al.  Inhibition of DNA and RNA synthesis by daunorubicin in sensitive and resistant Ehrlich ascites tumor cells in vitro. , 1972, Cancer research.

[64]  CHEMICAL MUTAGENS: PRINCIPLES AND METHODS FOR THEIR DETECTION , 1972 .

[65]  M. Waring,et al.  Variation of the supercoils in closed circular DNA by binding of antibiotics and drugs: evidence for molecular models involving intercalation. , 1970, Journal of molecular biology.

[66]  T. Nunoshiba,et al.  'Rec-lac test' for detecting SOS-inducing activity of environmental genotoxic substance. , 1991, Mutation research.

[67]  K. Drlica,et al.  Bacterial topoisomerases and the control of DNA supercoiling. , 1990, Trends in genetics : TIG.

[68]  C. Smith,et al.  Transcription regulates oxolinic acid-induced DNA gyrase cleavage at specific sites on the E. coli chromosome. , 1990, Nucleic acids research.

[69]  J. Battista,et al.  The SOS response and induced mutagenesis. , 1990, Progress in clinical and biological research.

[70]  D. DeMarini,et al.  Induction of prophage lambda by chlorophenols , 1990, Environmental and molecular mutagenesis.

[71]  G. Storz,et al.  Bacterial defenses against oxidative stress. , 1990, Trends in genetics : TIG.

[72]  H. H. Evans,et al.  Relationship between topoisomerase II and radiosensitivity in mouse L5178Y lymphoma strains. , 1989, Mutation research.

[73]  L. Liu,et al.  DNA topoisomerase poisons as antitumor drugs. , 1989, Annual review of biochemistry.

[74]  P. Muehlbauer,et al.  Genetic profile of a nalidixic acid analog: A model for the mechanism of sister chromatid exchange induction , 1989, Environmental and molecular mutagenesis.

[75]  H. Andersson,et al.  The production of chromosomal alterations in human lymphocytes by drugs known to interfere with the activity of DNA topoisomerase II. I. m-AMSA. , 1989, Carcinogenesis.

[76]  F. D. de Serres,et al.  Specific-locus mutations induced in eukaryotes (especially mammalian cells) by radiation and chemicals: a perspective. , 1989, Mutation research.

[77]  D. DeMarini,et al.  Use of the microscreen phage‐induction assay to assess the genotoxicity of 14 hazardous industrial wastes , 1988, Environmental and molecular mutagenesis.

[78]  D. DeMarini,et al.  Mutagenicity of topoisomerase-active agents in bacteriophage T4. , 1988, Teratogenesis, carcinogenesis, and mutagenesis.

[79]  E. Zeiger,et al.  Salmonella mutagenicity tests: IV. Results from the testing of 300 chemicals , 1988, Environmental and molecular mutagenesis.

[80]  R. Elespuru Inducible responses to dna damage in bacteria and mammalian cells , 1987, Environmental and molecular mutagenesis.

[81]  M. Moore,et al.  Mutagenesis of L5178Y/TK(+/-)-3.7.2C mouse lymphoma cells by the clastogen ellipticine. , 1987, Environmental mutagenesis.

[82]  T. Cebula Genetic and physiological modulation of anthracycline-induced mutagenesis in Salmonella typhimurium. , 1986, Environmental mutagenesis.

[83]  H. Vosberg DNA topoisomerases: enzymes that control DNA conformation. , 1985, Current topics in microbiology and immunology.

[84]  G. Walker,et al.  Genetic analyses of DNA repair: inference and extrapolation. , 1985, Annual review of genetics.

[85]  A. Pernet,et al.  Mechanism of inhibition of DNA gyrase by analogues of nalidixic acid: the target of the drugs is DNA. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[86]  J. Theiss,et al.  Genotoxic classification of anticancer drugs. , 1985, Teratogenesis, carcinogenesis, and mutagenesis.

[87]  R. Elespuru Induction of Bacteriophage Lambda by DNA-Interacting Chemicals , 1984 .

[88]  T. Rossman,et al.  The genetic toxicology of metal compounds: I. Induction of λ prophage in E coli WP2S(λ) , 1984 .