A Selective p38α Mitogen-Activated Protein Kinase Inhibitor Reverses Cartilage and Bone Destruction in Mice with Collagen-Induced Arthritis
暂无分享,去创建一个
H. Genant | Yebin Jiang | S. Medicherla | A. Protter | A. Kapoun | S. Chakravarty | J. Ma | R. Mangadu | G. O'young | G. Luedtke | I. Kerr | R. Almirez | S. Dugar | Jenny Zhao | E. Stebbins
[1] K. Vuolteenaho,et al. Inhibitors of Mitogen-Activated Protein Kinases Downregulate COX-2 Expression in Human Chondrocytes , 2005, Mediators of inflammation.
[2] G. Schreiner,et al. p38α Mitogen-Activated Protein Kinase Inhibition Improves Cardiac Function and Reduces Myocardial Damage in Isoproterenol-Induced Acute Myocardial Injury in Rats , 2004, Journal of cardiovascular pharmacology.
[3] I. Rioja,et al. Joint cytokine quantification in two rodent arthritis models: kinetics of expression, correlation of mRNA and protein levels and response to prednisolone treatment , 2004, Clinical and experimental immunology.
[4] S. Medicherla,et al. Antinociceptive action of a p38α MAPK inhibitor, SD-282, in a diabetic neuropathy model , 2004, Pain.
[5] Kwan Tat Steeve,et al. IL-6, RANKL, TNF-alpha/IL-1: interrelations in bone resorption pathophysiology. , 2004 .
[6] S. Kwan Tat,et al. IL-6, RANKL, TNF-alpha/IL-1: interrelations in bone resorption pathophysiology. , 2004, Cytokine & growth factor reviews.
[7] H. Genant,et al. Recombinant Human Parathyroid Hormone (1–34) [Teriparatide] Improves Both Cortical and Cancellous Bone Structure , 2003, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[8] N. Udagawa,et al. p38 Mitogen-activated protein kinase is crucially involved in osteoclast differentiation but not in cytokine production, phagocytosis, or dendritic cell differentiation of bone marrow macrophages. , 2003, Endocrinology.
[9] H. Yoshikawa,et al. Prevention of the onset and progression of collagen-induced arthritis in rats by the potent p38 mitogen-activated protein kinase inhibitor FR167653. , 2003, Arthritis and rheumatism.
[10] Y. Kadono,et al. Suppression of arthritic bone destruction by adenovirus-mediated dominant-negative Ras gene transfer to synoviocytes and osteoclasts. , 2003, Arthritis and rheumatism.
[11] B. Månsson,et al. Serum cartilage oligomeric matrix protein (COMP) decreases in rheumatoid arthritis patients treated with infliximab or etanercept , 2003, Arthritis research & therapy.
[12] U. Lerner,et al. IL-6, Leukemia Inhibitory Factor, and Oncostatin M Stimulate Bone Resorption and Regulate the Expression of Receptor Activator of NF-κB Ligand, Osteoprotegerin, and Receptor Activator of NF-κB in Mouse Calvariae1 , 2002, The Journal of Immunology.
[13] T. Nishihara,et al. p38 MAPK-mediated signals are required for inducing osteoclast differentiation but not for osteoclast function. , 2002, Endocrinology.
[14] J. Reeve. Recombinant human parathyroid hormone , 2002, BMJ : British Medical Journal.
[15] Matthew J. Silva,et al. SHIP-deficient mice are severely osteoporotic due to increased numbers of hyper-resorptive osteoclasts , 2002, Nature Network Boston.
[16] John C. Lee,et al. IL‐1‐ and TNF‐induced bone resorption is mediated by p38 mitogen activated protein kinase * , 2001, Journal of cellular physiology.
[17] I. McLay,et al. The discovery of RPR 200765A, a p38 MAP kinase inhibitor displaying a good oral anti-arthritic efficacy. , 2001, Bioorganic & medicinal chemistry.
[18] H. Genant,et al. Micro CT and Micro MR imaging of 3D architecture of animal skeleton. , 2000, Journal of musculoskeletal & neuronal interactions.
[19] L. Joosten,et al. IL-1 alpha beta blockade prevents cartilage and bone destruction in murine type II collagen-induced arthritis, whereas TNF-alpha blockade only ameliorates joint inflammation. , 1999, Journal of immunology.
[20] L. Joosten,et al. Protection against cartilage and bone destruction by systemic interleukin-4 treatment in established murine type II collagen-induced arthritis , 1999, Arthritis research.
[21] H Perrier,et al. Rofecoxib [Vioxx, MK-0966; 4-(4'-methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: a potent and orally active cyclooxygenase-2 inhibitor. Pharmacological and biochemical profiles. , 1999, The Journal of pharmacology and experimental therapeutics.
[22] F. Berenbaum,et al. Human chondrocyte culture models for studying cyclooxygenase expression and prostaglandin regulation of collagen gene expression. , 1999, Osteoarthritis and cartilage.
[23] C. Manthey,et al. Differential expression and activation of p38 mitogen-activated protein kinase alpha, beta, gamma, and delta in inflammatory cell lineages. , 1999, Journal of immunology.
[24] L. Joosten,et al. IL-1αβ Blockade Prevents Cartilage and Bone Destruction in Murine Type II Collagen-Induced Arthritis, Whereas TNF-α Blockade Only Ameliorates Joint Inflammation , 1999, The Journal of Immunology.
[25] H K Genant,et al. Assessment of rheumatoid arthritis using a modified scoring method on digitized and original radiographs. , 1998, Arthritis and rheumatism.
[26] M. Feldmann,et al. Modulation of angiogenic vascular endothelial growth factor by tumor necrosis factor alpha and interleukin-1 in rheumatoid arthritis. , 1998, Arthritis and rheumatism.
[27] Y. Suzuki,et al. Osteoclast-like cells in murine collagen induced arthritis. , 1998, The Journal of rheumatology.
[28] A. Clerk,et al. The p38‐MAPK inhibitor, SB203580, inhibits cardiac stress‐activated protein kinases/c‐Jun N‐terminal kinases (SAPKs/JNKs) , 1998, FEBS letters.
[29] R. Holmdahl,et al. Increased serum levels of cartilage oligomeric matrix protein in chronic erosive arthritis in rats , 1998, Arthritis and rheumatism.
[30] L. Klareskog,et al. Increased serum levels of cartilage oligomeric matrix protein and bone sialoprotein in rats with collagen arthritis. , 1997, British journal of rheumatology.
[31] W. B. van den Berg,et al. Dual role of IL-12 in early and late stages of murine collagen type II arthritis. , 1997, Journal of immunology.
[32] J C Lee,et al. Novel homologues of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles. , 1997, Biochemical and biophysical research communications.
[33] Philip R. Cohen,et al. Activation of the novel stress‐activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases , 1997, The EMBO journal.
[34] D E Griswold,et al. Pharmacological profile of SB 203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function. , 1996, The Journal of pharmacology and experimental therapeutics.
[35] L. Joosten,et al. Anticytokine treatment of established type II collagen-induced arthritis in DBA/1 mice: a comparative study using anti-TNFalpha, anti-IL-1alpha/beta and IL-1Ra. , 1996 .
[36] John P. Bilezikian,et al. Principles of Bone Biology , 1996 .
[37] M. Helsen,et al. Accelerated onset of collagen‐induced arthritis by remote inflammation , 1994, Clinical and experimental immunology.
[38] P. Wooley,et al. Influence of a recombinant human soluble tumor necrosis factor receptor FC fusion protein on type II collagen-induced arthritis in mice. , 1993, Journal of immunology.
[39] M. Feldmann,et al. Anti-tumor necrosis factor ameliorates joint disease in murine collagen-induced arthritis. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[40] D. Heinegård,et al. Cartilage oligomeric matrix protein: a novel marker of cartilage turnover detectable in synovial fluid and blood. , 1992, British journal of rheumatology.
[41] M. Cals,et al. Effects of human recombinant IL-1 beta on rheumatoid and non rheumatoid human synovial cell growth. , 1990, Cellular and molecular biology.
[42] R. Recker,et al. Bone histomorphometry : techniques and interpretation , 1983 .