Turning healthcare challenges into big data opportunities: A use‐case review across the pharmaceutical development lifecycle

Editor's Summary In order to draw meaning from the exponentially increasing quantity of healthcare data, it must be dealt with from a big data perspective, using technologies capable of processing massive amounts of data efficiently and securely. The pharmaceutical industry faces the big data challenge through all phases of the drug development lifecycle. Genomics, clinical monitoring and pharmacovigilance illustrate the value of a big data approach. Whether focusing on genetic and environmental disease risks, pattern detection through real time biosensors for patients or post-market monitoring of drug effectiveness, each area involves the collection and analysis of numerous variables and requires extreme computing power to reveal the details of interplay between the variables. To make big data work for pharmaceutical information, attention must be paid to data collection on a vast scale, from multiple sites and over long time periods. Big data support must be incorporated into interoperable electronic medical records and presented intuitively through visual analytics.

[1]  Bernt Schiele,et al.  Multi-graph Based Semi-supervised Learning for Activity Recognition , 2009, 2009 International Symposium on Wearable Computers.

[2]  Mark E. Borsuk,et al.  Using Bayesian networks to discover relations between genes, environment, and disease , 2013, BioData Mining.

[3]  Jingfa Xiao,et al.  Bioinformatics clouds for big data manipulation , 2012, Biology Direct.

[4]  N. Cooper,et al.  Beta event-related desynchronization as an index of individual differences in processing human facial expression: further investigations of autistic traits in typically developing adults , 2013, Front. Hum. Neurosci..

[5]  Eduard H. Hovy,et al.  Knowledge engineering tools for reasoning with scientific observations and interpretations: a neural connectivity use case , 2011, BMC Bioinformatics.

[6]  Hans-Michael Müller,et al.  The Neuroscience Information Framework: A Data and Knowledge Environment for Neuroscience , 2008, Neuroinformatics.

[7]  Ole J. Mengshoel,et al.  Accelerating Bayesian network parameter learning using Hadoop and MapReduce , 2012, BigMine '12.

[8]  Rudi Verbeeck,et al.  Quantifying the pathophysiological timeline of Alzheimer's disease. , 2011, Journal of Alzheimer's disease : JAD.

[9]  Hsien-Chang Lin,et al.  Use of electronic medical records differs by specialty and office settings. , 2013, Journal of the American Medical Informatics Association : JAMIA.

[10]  Alan J. Thomas,et al.  Sertraline or mirtazapine for depression in dementia (HTA-SADD): a randomised, multicentre, double-blind, placebo-controlled trial , 2011, The Lancet.