Transforming G proteins

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[2]  E. Reddy,et al.  Oncogenic mutant of Gα12 stimulates cell proliferation through cycloxygenase-2 signaling pathway , 1999, Oncogene.

[3]  E. Rozengurt,et al.  Gα13 Stimulates Rho-dependent Activation of the Cyclooxygenase-2 Promoter* , 1999, The Journal of Biological Chemistry.

[4]  Y. Kaziro,et al.  The Src family tyrosine kinase is involved in Rho-dependent activation of c-Jun N-terminal kinase by Gα12 , 1999, Oncogene.

[5]  G. Schultz,et al.  Differential Involvement of Gα12 and Gα13 in Receptor-mediated Stress Fiber Formation* , 1999, The Journal of Biological Chemistry.

[6]  J. Gutkind,et al.  A Novel PDZ Domain Containing Guanine Nucleotide Exchange Factor Links Heterotrimeric G Proteins to Rho* , 1999, The Journal of Biological Chemistry.

[7]  J. Mao,et al.  Guanine nucleotide exchange factor GEF115 specifically mediates activation of Rho and serum response factor by the G protein alpha subunit Galpha13. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[8]  Yun Jiang,et al.  The G protein Gα12 stimulates Bruton's tyrosine kinase and a rasGAP through a conserved PH/BM domain , 1998, Nature.

[9]  Melvin I. Simon,et al.  Specific Involvement of G Proteins in Regulation of Serum Response Factor-mediated Gene Transcription by Different Receptors* , 1998, The Journal of Biological Chemistry.

[10]  H. Mano,et al.  Tec/Bmx non‐receptor tyrosine kinases are involved in regulation of Rho and serum response factor by Gα12/13 , 1998, The EMBO journal.

[11]  P C Sternweis,et al.  Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13. , 1998, Science.

[12]  E. Rozengurt,et al.  Gα12 and Gα13 Stimulate Rho-dependent Tyrosine Phosphorylation of Focal Adhesion Kinase, Paxillin, and p130 Crk-associated Substrate* , 1998, The Journal of Biological Chemistry.

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[15]  S. Park,et al.  The α-Subunit of the Heterotrimeric G Protein G13Activates a Phospholipase D Isozyme by a Pathway Requiring Rho Family GTPases* , 1998, The Journal of Biological Chemistry.

[16]  G. Schultz,et al.  The G-protein G13 but Not G12 Mediates Signaling from Lysophosphatidic Acid Receptor via Epidermal Growth Factor Receptor to Rho* , 1998, The Journal of Biological Chemistry.

[17]  J. Gutkind,et al.  Gα12- and Gα13-Subunits of Heterotrimeric G-Proteins A Novel Family of Oncogenes , 1998 .

[18]  John G. Collard,et al.  Lysophosphatidic Acid Induces Threonine Phosphorylation of Tiam1 in Swiss 3T3 Fibroblasts via Activation of Protein Kinase C* , 1997, The Journal of Biological Chemistry.

[19]  N. Dhanasekaran,et al.  Ras-dependent Signaling by the GTPase-deficient Mutant of Gα12 * , 1997, The Journal of Biological Chemistry.

[20]  J. Gutkind,et al.  The small GTP-binding protein Rho links G protein-coupled receptors and Galpha12 to the serum response element and to cellular transformation. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[21]  N. Takuwa,et al.  Ras activity late in G1 phase required for p27kip1 downregulation, passage through the restriction point, and entry into S phase in growth factor-stimulated NIH 3T3 fibroblasts , 1997, Molecular and cellular biology.

[22]  K. Heidenreich,et al.  Apoptosis Induced by Withdrawal of Trophic Factors Is Mediated by p38 Mitogen-activated Protein Kinase* , 1997, The Journal of Biological Chemistry.

[23]  T. M. Johnson,et al.  Rac1 is required for cell proliferation and G2/M progression. , 1997, The Biochemical journal.

[24]  A. Chan,et al.  Cooperative transformation of NIH3T3 cells by Gα12 and Rac1 , 1997, Oncogene.

[25]  J. Olefsky,et al.  The G12 coupled thrombin receptor stimulates mitogenesis through the Shc SH2 domain , 1997, Oncogene.

[26]  G. Cooper,et al.  Ras links growth factor signaling to the cell cycle machinery via regulation of cyclin D1 and the Cdk inhibitor p27KIP1 , 1997, Molecular and cellular biology.

[27]  K. Skorecki,et al.  Induction of Cytosolic Phospholipase A2 by Oncogenic Ras in Human Non-small Cell Lung Cancer* , 1997, The Journal of Biological Chemistry.

[28]  M. Ivan,et al.  GH3 cells expressing constitutively active Gsα (Q227L) show enhanced hormone secretion and proliferation , 1997, Molecular and Cellular Endocrinology.

[29]  K. Kurokawa,et al.  Dependence of Activated Gα12-induced G1 to S Phase Cell Cycle Progression on Both Ras/Mitogen-activated Protein Kinase and Ras/Rac1/Jun N-terminal Kinase Cascades in NIH3T3 Fibroblasts* , 1997, The Journal of Biological Chemistry.

[30]  M. Kitagawa,et al.  Geranylgeranylated Rho Small GTPase(s) Are Essential for the Degradation of p27Kip1 and Facilitate the Progression from G1 to S Phase in Growth-stimulated Rat FRTL-5 Cells* , 1997, The Journal of Biological Chemistry.

[31]  S. Kudoh,et al.  Protein Kinase C, but Not Tyrosine Kinases or Ras, Plays a Critical Role in Angiotensin II-induced Activation of Raf-1 Kinase and Extracellular Signal-regulated Protein Kinases in Cardiac Myocytes* , 1996, The Journal of Biological Chemistry.

[32]  W. Westra,et al.  Transformation of rat thyroid follicular cells stably transfected with cholera toxin A1 fragment. , 1996, Endocrinology.

[33]  R. Lefkowitz,et al.  Mitogenic signaling via G protein-coupled receptors. , 1996, Endocrine reviews.

[34]  W. Kolch,et al.  Negative regulation of Raf-1 by phosphorylation of serine 621 , 1996, Molecular and cellular biology.

[35]  N. Ahn,et al.  Gα12 and Gα13 Regulate Extracellular Signal-regulated Kinase and c-Jun Kinase Pathways by Different Mechanisms in COS-7 Cells* , 1996, The Journal of Biological Chemistry.

[36]  M. Karin,et al.  Gα12 Stimulates c-Jun NH2-terminal Kinase through the Small G Proteins Ras and Rac* , 1996, The Journal of Biological Chemistry.

[37]  N. Dhanasekaran,et al.  Signaling by the G12 class of G proteins. , 1996, Cellular signalling.

[38]  D. Barber,et al.  G13 Stimulates Na-H Exchange through Distinct Cdc42-dependent and RhoA-dependent Pathways (*) , 1996, The Journal of Biological Chemistry.

[39]  S. Hermouet,et al.  In vitro and in vivo growth inhibition of murine melanoma K-1735 cell by a dominant negative mutant alpha subunit of the Gi2 protein. , 1996, Cellular signalling.

[40]  James A. Koziol,et al.  A Note on Signed Rank Tests for the Changepoint Problem , 1996 .

[41]  G. Johnson,et al.  Gα12 and Gα13 Stimulate Rho-dependent Stress Fiber Formation and Focal Adhesion Assembly (*) , 1995, The Journal of Biological Chemistry.

[42]  A. Ashworth,et al.  An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1 , 1995, Science.

[43]  E. Peles,et al.  Protein tyrosine kinase PYK2 involved in Ca2+-induced regulation of ion channel and MAP kinase functions , 1995, Nature.

[44]  H. Bourne.  Team blue sees red , 1995, Nature.

[45]  L. Heasley,et al.  Activation of Jun Kinase/Stress-activated Protein Kinase by GTPase-deficient Mutants of Gα12 and Gα13(*) , 1995, The Journal of Biological Chemistry.

[46]  R. Treisman,et al.  The Rho family GTPases RhoA, Racl , and CDC42Hsregulate transcriptional activation by SRF , 1995, Cell.

[47]  L. Heasley,et al.  G protein-coupled receptor systems involved in cell growth and oncogenesis. , 1995, Endocrine reviews.

[48]  T. Sasaki,et al.  Rho as a regulator of the cytoskeleton. , 1995, Trends in biochemical sciences.

[49]  T. Voyno-Yasenetskaya,et al.  Potent Transforming Activity of the G13 α Subunit Defines a Novel Family of Oncogenes , 1994 .

[50]  S. Cook,et al.  Inhibition by cAMP of Ras-dependent activation of Raf. , 1993, Science.

[51]  P. Dent,et al.  Inhibition of the EGF-activated MAP kinase signaling pathway by adenosine 3',5'-monophosphate. , 1993, Science.

[52]  E. Krebs,et al.  Protein kinase A antagonizes platelet-derived growth factor-induced signaling by mitogen-activated protein kinase in human arterial smooth muscle cells. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[53]  J. Lawrence,et al.  Increasing cAMP attenuates activation of mitogen-activated protein kinase. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[54]  J. Bos,et al.  cAMP antagonizes p21ras‐directed activation of extracellular signal‐regulated kinase 2 and phosphorylation of mSos nucleotide exchange factor. , 1993, The EMBO journal.

[55]  M. Simon,et al.  The transforming activity of activated Gα12 , 1993 .

[56]  E. Friedman,et al.  Activating mutations of the Gs alpha-gene in nonfunctioning pituitary tumors. , 1993, The Journal of clinical endocrinology and metabolism.

[57]  S. Hermouet,et al.  Mitogenic effects of pertussis toxin-sensitive G-protein α subunits: The mitogenic action of αi2 in NIH 3T3 cells is mimicked by αi1, but not αi3 , 1993 .

[58]  T. Fleming,et al.  Expression cDNA cloning of a transforming gene encoding the wild-type G alpha 12 gene product , 1993, Molecular and cellular biology.

[59]  J. Gutkind,et al.  Mutated alpha subunit of the Gq protein induces malignant transformation in NIH 3T3 cells , 1992, Molecular and cellular biology.

[60]  Anne J. Ridley,et al.  The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors , 1992, Cell.

[61]  G. Johnson,et al.  Analysis of the fibroblast transformation potential of GTPase-deficient gip2 oncogenes , 1992, Molecular and cellular biology.

[62]  G. Johnson,et al.  Mitogenic pathways regulated by G protein oncogenes. , 1992, Molecular biology of the cell.

[63]  J. Pouysségur,et al.  Transmembrane receptors and intracellular pathways that control cell proliferation. , 1992, Annual review of physiology.

[64]  H. Bourne,et al.  A mutant alpha subunit of Gi2 induces neoplastic transformation of Rat-1 cells. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[65]  M. Brann,et al.  Muscarinic acetylcholine receptor subtypes as agonist-dependent oncogenes. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[66]  Eric Wieschaus,et al.  The drosophila gastrulation gene concertina encodes a Gα-like protein , 1991, Cell.

[67]  E. Kawasaki,et al.  Two G protein oncogenes in human endocrine tumors. , 1990, Science.

[68]  H. Bourne,et al.  Increased mitogenic responsiveness of Swiss 3T3 cells expressing constitutively active Gs alpha. , 1990, Biochemical and biophysical research communications.

[69]  M. Simon,et al.  Diversity of the G-protein family: Sequences from five additional α subunits in the mouse , 1989 .

[70]  H. Bourne,et al.  GTPase inhibiting mutations activate the α chain of Gs and stimulate adenylyl cyclase in human pituitary tumours , 1989, Nature.

[71]  H. Kung,et al.  S-phase induction and transformation of quiescent NIH 3T3 cells by microinjection of phospholipase C. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[72]  J. Jauniaux,et al.  The cyclic AMP-mediated stimulation of cell proliferation. , 1989, Trends in biochemical sciences.

[73]  G. Giannattasio,et al.  Altered Gs and adenylate cyclase activity in human GH-secreting pituitary adenomas , 1987, Nature.

[74]  A. Zelenetz,et al.  Transformation of NIH/3T3 mouse cells by DNA of Rous sarcoma virus , 1979, Cell.