Hepatitis C virus chronic infection as a common cause of mixed cryoglobulinaemia and autoimmune liver disease

Abstract. Objectives. Mixed cryoglobulinaemia (MC) and autoimmune chronic hepatitis (AI‐CH) are frequently associated with hepatitis C virus (HCV) chronic infection. Because HCV represents a possible common aetiological factor, the aim of the present study is to investigate the clinico‐serological alterations of both MC and AI‐CH and to verify a possible overlap between these disorders.

[1]  G. Pasero,et al.  Antibodies to hepatitis C virus in patients with mixed cryoglobulinemia. , 2010, Arthritis and rheumatism.

[2]  K. Mergener,et al.  Viruses and auto‐immune hepatitis , 1994, European journal of clinical investigation.

[3]  G. Pasero,et al.  Infection of Peripheral Blood Mononuclear Cells by Hepatitis C Virus in Mixed Cryoglobulinemia , 1993 .

[4]  S. Bombardieri,et al.  Interferon-alpha in mixed cryoglobulinemia patients: a randomized, crossover-controlled trial. , 1993, Blood.

[5]  R. Chung,et al.  A role for hepatitis C virus infection in type II cryoglobulinemia. , 1992, The New England journal of medicine.

[6]  C. Bréchot,et al.  Infection of peripheral mononuclear blood cells by hepatitis C virus. , 1992, Journal of hepatology.

[7]  S. Bombardieri,et al.  Peripheral neuropathy in mixed cryoglobulinemia: clinical and electrophysiologic investigations. , 1992, The Journal of rheumatology.

[8]  S. Kaneko,et al.  Anti-HCV, anti-GOR, and autoimmunity , 1992, The Lancet.

[9]  M. Manns,et al.  Anti-GOR and hepatitis C virus in autoimmune liver diseases , 1992, The Lancet.

[10]  S. Bombardieri,et al.  Alpha interferon in the treatment of mixed cryoglobulinaemia patients. , 1991, European journal of cancer.

[11]  Q. Choo,et al.  Hepatitis C virus replication in 'autoimmune' chronic hepatitis. , 1991, Journal of hepatology.

[12]  G. Pasero,et al.  Association between hepatitis C virus and mixed cryoglobulinemia [see comment]. , 1991, Clinical and experimental rheumatology.

[13]  S. Kaneko,et al.  Severity of liver disease with different hepatitis C viral clones , 1991, The Lancet.

[14]  D. Vergani,et al.  Antibodies to hepatitis C virus in autoimmune liver disease: evidence for geographical heterogeneity , 1991, The Lancet.

[15]  I. Mcfarlane.  Autoimmunity and Hepatotropic Viruses , 1991, Seminars in liver disease.

[16]  L. Pucillo,et al.  Cryoglobulinaemia and hepatitis C virus , 1991, The Lancet.

[17]  B. Frangione,et al.  Mixed cryoglobulinemia cross-reactive idiotypes: implications for the relationship of MC to rheumatic and lymphoproliferative diseases. , 1991, Seminars in hematology.

[18]  E. Muchmore,et al.  Non-A, non-B hepatitis specific antibodies directed at host-derived epitope: implication for an autoimmune process , 1990, The Lancet.

[19]  L. Perrin,et al.  Hepatitis C virus in patients with cryoglobulinemia type II. , 1990, The Journal of infectious diseases.

[20]  C. Bréchot,et al.  Amplification of hepatitis delta virus RNA sequences by polymerase chain reaction: a tool for viral detection and cloning. , 1990, Molecular and cellular probes.

[21]  S. Bombardieri,et al.  Low-antigen-content diet in the treatment of patients with mixed cryoglobulinemia. , 1989, The American journal of medicine.

[22]  M. Houghton,et al.  Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. , 1989, Science.

[23]  Griffin,et al.  Major antigen of liver kidney microsomal autoantibodies in idiopathic autoimmune hepatitis is cytochrome P450db1. , 1989, The Journal of clinical investigation.

[24]  F. Alvarez,et al.  Chronic active hepatitis associated with antiliver/kidney microsome antibody type 1: A second type of “autoimmune” hepatitis , 1987, Hepatology.

[25]  G. Pasero,et al.  Cryoglobulins and immune complexes in essential mixed cryoglobulinemia , 1986, La Ricerca in clinica e in laboratorio.

[26]  G. Pasero,et al.  Plasma-exchange in mixed cryoglobulinemia. Effects on renal, liver and neurologic involvement , 1986, La Ricerca in clinica e in laboratorio.

[27]  P. Pontisso,et al.  Detection of hepatitis B virus DNA in mononuclear blood cells. , 1984, British medical journal.

[28]  G. Hughes,et al.  Antibodies to extractable nuclear antigens in 173 patients with DNA-binding positive SLE: an association between antibodies to ribonucleoprotein and Sm antigens observed by counterimmunoelectrophoresis. , 1982, Journal of clinical & laboratory immunology.

[29]  Y. Levo,et al.  Mixed cryoglobulinemia: clinical aspects and long-term follow-up of 40 patients. , 1980, The American journal of medicine.

[30]  G. Pasero,et al.  Liver involvement in essential mixed cryoglobulinemia , 1979, La Ricerca in clinica e in laboratorio.

[31]  Y. Levo,et al.  Association between hepatitis B virus and essential mixed cryoglobulinemia. , 1977, The New England journal of medicine.

[32]  M. Meltzer,et al.  Cryoglobulinemia--a clinical and laboratory study. II. Cryoglobulins with rheumatoid factor activity. , 1966, The American journal of medicine.

[33]  G. Pasero,et al.  Hepatitis C virus in mixed cryoglobulinemia and B cell lymphoma. , 1994, Clinical and experimental rheumatology.

[34]  S. Bombardieri,et al.  Hepatitis C virus and mixed cryoglobulinaemia. , 1993, European journal of clinical investigation.

[35]  P. Highfield,et al.  Hepatitis C virus, autoimmune liver disease and cryoglobulinaemic hepatitis. , 1992, Journal of hepatology.

[36]  S. Pileri,et al.  Essential mixed cryoglobulinemia, type II: a manifestation of a low-grade malignant lymphoma? Clinical-morphological study of 12 cases with special reference to immunohistochemical findings in liver frozen sections. , 1988, Acta haematologica.

[37]  J. F. Kent,et al.  Precise standardization of reagents for complement fixation. , 1963, The American journal of tropical medicine and hygiene.