Long-term depression in hippocampal interneurons: joint requirement for pre- and postsynaptic events.

Long-term depression (LTD) is a well-known form of synaptic plasticity of principal neurons in the mammalian brain. Whether such changes occur in interneurons is still controversial. CA3 hippocampal interneurons expressing Ca2+-permeable AMPA receptors exhibited LTD after tetanic stimulation of CA3 excitatory inputs. LTD was independent of NMDA receptors and required both Ca2+ influx through postsynaptic AMPA receptors and activation of presynaptic mGluR7-like receptors. These results point to the capability of interneurons to undergo plastic changes of synaptic strength through joint activation of pre- and postsynaptic glutamate receptors.

[1]  Daniel Johnston,et al.  Multiple forms of LTP in hippocampal CA3 neurons use a common postsynaptic mechanism , 1999, Nature Neuroscience.

[2]  Mark von Zastrow,et al.  Rapid redistribution of glutamate receptors contributes to long-term depression in hippocampal cultures , 1999, Nature Neuroscience.

[3]  R. Nicoll,et al.  Rapid, Activation-Induced Redistribution of Ionotropic Glutamate Receptors in Cultured Hippocampal Neurons , 1999, The Journal of Neuroscience.

[4]  Z. Mainen,et al.  Use-dependent AMPA receptor block in mice lacking GluR2 suggests postsynaptic site for LTP expression , 1998, Nature Neuroscience.

[5]  K. Tóth,et al.  Afferent-specific innervation of two distinct AMPA receptor subtypes on single hippocampal interneurons , 1998, Nature Neuroscience.

[6]  Thanos Tzounopoulos,et al.  A Role for cAMP in Long-Term Depression at Hippocampal Mossy Fiber Synapses , 1998, Neuron.

[7]  Pankaj Sah,et al.  Calcium-permeable AMPA receptors mediate long-term potentiation in interneurons in the amygdala , 1998, Nature.

[8]  K. Tóth,et al.  Target-specific expression of presynaptic mossy fiber plasticity. , 1998, Science.

[9]  P. Somogyi,et al.  Unitary IPSPs evoked by interneurons at the stratum radiatum‐stratum lacunosum‐moleculare border in the CA1 area of the rat hippocampus in vitro , 1998, The Journal of physiology.

[10]  P. Ornstein,et al.  LY341495 is a nanomolar potent and selective antagonist of group II metabotropic glutamate receptors , 1998, Neuropharmacology.

[11]  R. Dingledine,et al.  Differential Dependence on GluR2 Expression of Three Characteristic Features of AMPA Receptors , 1997, The Journal of Neuroscience.

[12]  P. Emson,et al.  Localization of mGluR4 protein in the rat cerebral cortex and hippocampus , 1997, Neuroreport.

[13]  Ayae Kinoshita,et al.  Differential Presynaptic Localization of Metabotropic Glutamate Receptor Subtypes in the Rat Hippocampus , 1997, The Journal of Neuroscience.

[14]  R. Nicoll,et al.  Silent Synapses Speak Up , 1997, Neuron.

[15]  R. Anwyl,et al.  mGluR II agonist inhibition of LTP induction, and mGluR II antagonist inhibition of LTD induction, in the dentate gyrus in vitro , 1997, Neuroreport.

[16]  Yue Wang,et al.  Induction of LTD in the dentate gyrus in vitro is NMDA receptor independent, but dependent on Ca2+ influx via low-voltage-activated Ca2+ channels and release of Ca2+ from intracellular stores. , 1997, Journal of neurophysiology.

[17]  B. Ballyk,et al.  Activity of 2,3-benzodiazepines at Native Rat and Recombinant Human Glutamate Receptors In Vitro: Stereospecificity and Selectivity Profiles , 1996, Neuropharmacology.

[18]  C. McBain,et al.  Long-Term Potentiation in Distinct Subtypes of Hippocampal Nonpyramidal Neurons , 1996, The Journal of Neuroscience.

[19]  S. Nakanishi,et al.  Impairment of Hippocampal Mossy Fiber LTD in Mice Lacking mGluR2 , 1996, Science.

[20]  R. Dingledine,et al.  Block of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors by polyamines and polyamine toxins. , 1996, The Journal of pharmacology and experimental therapeutics.

[21]  T. Isa,et al.  Spermine blocks synaptic transmission mediated by Ca2+-permeable AMPA receptors , 1996, Neuroreport.

[22]  S. Ozawa,et al.  Relationship between calcium permeability and rectification properties of AMPA receptors in cultured rat hippocampal neurons , 1994, Neuroscience Letters.

[23]  G. Westbrook,et al.  Cloning and expression of a new member of the L-2-amino-4-phosphonobutyric acid-sensitive class of metabotropic glutamate receptors. , 1994, Molecular pharmacology.

[24]  A. Konnerth,et al.  A single amino acid determines the subunit-specific spider toxin block of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate/kainate receptor channels. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[25]  H. Monyer,et al.  Argiotoxin detects molecular differences in AMPA receptor channels , 1993, Neuron.

[26]  R. Dingledine,et al.  Heterogeneity of synaptic glutamate receptors on CA3 stratum radiatum interneurones of rat hippocampus. , 1993, The Journal of physiology.

[27]  T. Bliss,et al.  A synaptic model of memory: long-term potentiation in the hippocampus , 1993, Nature.

[28]  S. Heinemann,et al.  Ca2+ permeability of KA-AMPA--gated glutamate receptor channels depends on subunit composition , 1991, Science.

[29]  A. Marty,et al.  Calcium entry increases the sensitivity of cerebellar Purkinje cells to applied GABA and decreases inhibitory synaptic currents , 1991, Neuron.

[30]  R. Nicoll,et al.  Comparison of two forms of long-term potentiation in single hippocampal neurons. , 1990, Science.

[31]  P. Usherwood,et al.  Spider toxins as tools for dissecting elements of excitatory amino acid transmission , 1988, Trends in Neurosciences.

[32]  J. Pin,et al.  Pharmacology and functions of metabotropic glutamate receptors. , 1997, Annual review of pharmacology and toxicology.

[33]  R. Dingledine,et al.  Regulation of excitatory input to inhibitory interneurons of the dentate gyrus during hypoxia. , 1997, Journal of neurophysiology.

[34]  M. Bear,et al.  Long-term depression in hippocampus. , 1996, Annual review of neuroscience.