Health Risks of Air Pollution in Europe HRAPIE Project

This document presents recommendations for concentration–response functions for key pollutants to be included in cost–benefit analysis supporting the revision of the European Union’s air quality policy. It provides a response to a question posed by the European Commission in the framework of the WHO “Health risks of air pollution in Europe – HRAPIE” project. The essential background to this response was developed through a review of evidence on health aspects of air pollutants summarized by an earlier WHO project, “Review of evidence on health aspects of air pollution – REVIHAAP”. This report recommends concentration–response functions and associated background information for several mortality and morbidity effects associated with shortand long-term exposure to particulate matter, ozone and nitrogen dioxide. This publication arises from the HRAPIE project and was co-funded by the European Union.

[1]  W S Linn,et al.  A study of twelve Southern California communities with differing levels and types of air pollution. II. Effects on pulmonary function. , 1999, American journal of respiratory and critical care medicine.

[2]  Haidong Kan,et al.  Association Between Long-term Exposure to Outdoor Air Pollution and Mortality in China: A Cohort Study , 2011 .

[3]  M. Jerrett,et al.  A Cohort Study of Traffic-Related Air Pollution and Mortality in Toronto, Ontario, Canada , 2009, Environmental health perspectives.

[4]  J. Schwartz,et al.  Short-term effects of nitrogen dioxide on mortality: an analysis within the APHEA project , 2006, European Respiratory Journal.

[5]  J. Schwartz,et al.  The Effect of Fine and Coarse Particulate Air Pollution on Mortality: A National Analysis , 2009, Environmental health perspectives.

[6]  H. R. Anderson,et al.  Long-term exposure to outdoor air pollution and the prevalence of asthma: meta-analysis of multi-community prevalence studies , 2013, Air Quality, Atmosphere & Health.

[7]  J. Ayres,et al.  Particulate air pollution and panel studies in children: a systematic review , 2004, Occupational and Environmental Medicine.

[8]  B. Ostro,et al.  Air pollution and morbidity revisited: A specification test , 1987 .

[9]  F. Lurmann,et al.  Global goods movement and the local burden of childhood asthma in southern California. , 2009, American journal of public health.

[10]  P. F. Adams,et al.  Current estimates from the National Health Interview Survey, 1994. , 1995, Vital and health statistics. Series 10, Data from the National Health Survey.

[11]  V. Wagner,et al.  Short-term associations between fine and coarse particles and hospital admissions for cardiorespiratory diseases in six French cities , 2007, Occupational and Environmental Medicine.

[12]  Manuel Pastor,et al.  Near-Roadway Pollution and Childhood Asthma: Implications for Developing “Win–Win” Compact Urban Development and Clean Vehicle Strategies , 2012, Environmental health perspectives.

[13]  Sabit Cakmak,et al.  Associations between Short-Term Changes in Nitrogen Dioxide and Mortality in Canadian Cities , 2004, Archives of environmental health.

[14]  Geir Aamodt,et al.  Relation between concentration of air pollution and cause-specific mortality: four-year exposures to nitrogen dioxide and particulate matter pollutants in 470 neighborhoods in Oslo, Norway. , 2007, American journal of epidemiology.

[15]  B. Hwang,et al.  Air pollution and prevalence of bronchitic symptoms among children in Taiwan. , 2010, Chest.

[16]  Joel Schwartz,et al.  Chronic Exposure to Fine Particles and Mortality: An Extended Follow-up of the Harvard Six Cities Study from 1974 to 2009 , 2012, Environmental health perspectives.

[17]  S. Weiland,et al.  Global variation in the prevalence and severity of asthma symptoms: Phase Three of the International Study of Asthma and Allergies in Childhood (ISAAC) , 2009, Thorax.

[18]  Alan D. Lopez,et al.  Counting the dead and what they died from: an assessment of the global status of cause of death data. , 2005, Bulletin of the World Health Organization.

[19]  M. Stafoggia,et al.  Associations between Fine and Coarse Particles and Mortality in Mediterranean Cities: Results from the MED-PARTICLES Project , 2013, Environmental health perspectives.

[20]  F. Speizer,et al.  PM10, and children's respiratory symptoms and lung function in the PATY study , 2012, European Respiratory Journal.

[21]  Gail M. Williams,et al.  The short-term effects of air pollution on hospital admissions in four Australian cities. , 2005, Australian and New Zealand journal of public health.

[22]  Thomas J. Smith,et al.  Long-term ambient multipollutant exposures and mortality. , 2011, American journal of respiratory and critical care medicine.

[23]  T J Woodruff,et al.  The relationship between selected causes of postneonatal infant mortality and particulate air pollution in the United States. , 1997, Environmental health perspectives.

[24]  Giovanna Berti,et al.  Short-term Associations between Fine and Coarse Particulate Matter and Hospitalizations in Southern Europe: Results from the MED-PARTICLES Project , 2013, Environmental health perspectives.

[25]  R. Harrison,et al.  New considerations for PM, Black Carbon and particle number concentration for air quality monitoring across different European cities , 2011 .

[26]  Christian Schindler,et al.  Improvements in PM10 exposure and reduced rates of respiratory symptoms in a cohort of Swiss adults (SAPALDIA). , 2009, American journal of respiratory and critical care medicine.

[27]  Alan D. Lopez,et al.  Comparative quantification of health risks. Global and regional burden of disease attributable to selected major risk factors. Volume 1. , 2004 .

[28]  Michal Krzyzanowski,et al.  URBAN AIR POLLUTION , 1999 .

[29]  M. Kivimäki,et al.  Self-report as an indicator of incident disease. , 2010, Annals of epidemiology.

[30]  A. Peters,et al.  Associations between mortality and air pollution in central Europe. , 2000, Environmental health perspectives.

[31]  Daniel Krewski,et al.  On measurement error adjustment methods in Poisson regression , 1999 .

[32]  D. Abbey,et al.  Chronic respiratory symptoms associated with estimated long-term ambient concentrations of fine particulates less than 2.5 microns in aerodynamic diameter (PM2.5) and other air pollutants. , 1995, Journal of exposure analysis and environmental epidemiology.

[33]  K. Berhane,et al.  Prospective study of air pollution and bronchitic symptoms in children with asthma. , 2003, American journal of respiratory and critical care medicine.

[34]  A. Peters,et al.  Short-term effects of particulate air pollution on respiratory morbidity in asthmatic children. , 1997, The European respiratory journal.

[35]  P Rudnai,et al.  Parental education and children's respiratory and allergic symptoms in the Pollution and the Young (PATY) study , 2006, European Respiratory Journal.

[36]  Bang Quoc Ho,et al.  Urban Air Pollution , 1994 .

[37]  B. Ostro,et al.  Air pollution and acute respiratory morbidity: an observational study of multiple pollutants. , 1989, Environmental research.

[38]  Kurt Straif,et al.  The carcinogenicity of outdoor air pollution. , 2013, The Lancet. Oncology.

[39]  J. Just,et al.  Short-term effect of winter air pollution on respiratory health of asthmatic children in Paris. , 1998, The European respiratory journal.

[40]  A. Biggeri,et al.  Respiratory symptoms in children living near busy roads and their relationship to vehicular traffic: results of an Italian multicenter study (SIDRIA 2) , 2009, Environmental health : a global access science source.

[41]  A. Tobías,et al.  Coarse Particles From Saharan Dust and Daily Mortality , 2008, Epidemiology.

[42]  B. Brunekreef,et al.  Effect of photochemical air pollution on acute respiratory symptoms in children. , 1995, American journal of respiratory and critical care medicine.

[43]  C. Linares,et al.  Short-term effect of PM2.5 on daily hospital admissions in Madrid (2003–2005) , 2010, International journal of environmental health research.

[44]  Gary W. Fuller,et al.  Urban Ambient Particle Metrics and Health: A Time-series Analysis , 2010, Epidemiology.

[45]  B. Brunekreef,et al.  Acute effects of urban air pollution on respiratory health of children with and without chronic respiratory symptoms. , 1999, Occupational and environmental medicine.

[46]  Jens Borken-Kleefeld,et al.  Policy Scenarios for the revision of the thematic strategy on air pollution , 2013 .

[47]  J Schwartz,et al.  Investigating the dose-response relation between air pollution and total mortality in the APHEA-2 multicity project , 2003, Occupational and environmental medicine.

[48]  D. Rogers Pulmonary mucus: Pediatric perspective , 2003, Pediatric pulmonology.

[49]  Antonella Zanobetti,et al.  Air pollution and health: a European and North American approach (APHENA). , 2009, Research report.

[50]  C. Hewitt,et al.  Air pollution in the United Kingdom , 1997 .

[51]  Kazuhiko Ito,et al.  Long-term ozone exposure and mortality. , 2009, The New England journal of medicine.

[52]  Alan D. Lopez,et al.  A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010 , 2012, The Lancet.

[53]  Wolfgang Kreyling,et al.  The influence of improved air quality on mortality risks in Erfurt, Germany. , 2009, Research report.

[54]  A. Hansell,et al.  Ambient air pollution: a cause of COPD? , 2013, European Respiratory Journal.

[55]  F. Lurmann,et al.  An Attributable Risk Model for Exposures Assumed to Cause Both Chronic Disease and its Exacerbations , 2008, Epidemiology.

[56]  M. Järvelin,et al.  Systematic review of worldwide variations of the prevalence of wheezing symptoms in children , 2008, Environmental health : a global access science source.

[57]  F. Lurmann,et al.  Costs of childhood asthma due to traffic-related pollution in two California communities , 2012, European Respiratory Journal.

[58]  A. Peters,et al.  Long-term air pollution exposure and cardio- respiratory mortality: a review , 2013, Environmental Health.

[59]  S. Walters,et al.  Particulate matter and daily mortality and hospital admissions in the west midlands conurbation of the United Kingdom: associations with fine and coarse particles, black smoke and sulphate , 2001, Occupational and environmental medicine.

[60]  J. Schwartz,et al.  Reduction in fine particulate air pollution and mortality: Extended follow-up of the Harvard Six Cities study. , 2006, American journal of respiratory and critical care medicine.

[61]  S. Jack,et al.  Current estimates from the National Health Interview Survey. , 1981, Vital and health statistics. Series 10, Data from the National Health Survey.

[62]  Hanna Vehkamäki,et al.  Formation and growth rates of ultrafine atmospheric particles: a review of observations , 2004 .

[63]  B. Festy Review of evidence on health aspects of air pollution – REVIHAAP Project. Technical Report. World Health Organization Regional Office for Europe 2013 , 2013 .

[64]  Itai Kloog,et al.  Long- and Short-Term Exposure to PM2.5 and Mortality: Using Novel Exposure Models , 2013, Epidemiology.

[65]  M. Stafoggia,et al.  Long-Term Exposure to Urban Air Pollution and Mortality in a Cohort of More than a Million Adults in Rome , 2013, Environmental health perspectives.

[66]  Martin Kraft,et al.  Long-Term Exposure to Ambient Air Pollution and Cardiopulmonary Mortality in Women , 2006, Epidemiology.

[67]  Derek G. Cook,et al.  Mortality associations with long-term exposure to outdoor air pollution in a national English cohort , 2013 .

[68]  M. Braniš,et al.  Association of size-resolved number concentrations of particulate matter with cardiovascular and respiratory hospital admissions and mortality in Prague, Czech Republic , 2010, Inhalation toxicology.

[69]  Tracey J. Woodruff,et al.  Air Pollution and Postneonatal Infant Mortality in the United States, 1999–2002 , 2007, Environmental health perspectives.

[70]  Manfred Neuberger,et al.  Extended effects of air pollution on cardiopulmonary mortality in Vienna , 2007 .

[71]  Joel Schwartz,et al.  Acute effects of ozone on mortality from the "air pollution and health: a European approach" project. , 2004, American journal of respiratory and critical care medicine.

[72]  F. Ballester,et al.  Air pollution and mortality in the Canary Islands: a time-series analysis , 2010, Environmental health : a global access science source.

[73]  S J London,et al.  A study of twelve Southern California communities with differing levels and types of air pollution. I. Prevalence of respiratory morbidity. , 1999, American journal of respiratory and critical care medicine.

[74]  R. Burnett,et al.  Air pollution and disability days in Toronto: results from the national population health survey. , 2002, Environmental research.

[75]  Michael Jerrett,et al.  Spatiotemporal analysis of air pollution and mortality in California based on the American Cancer Society cohort , 2011 .

[76]  D. Abbey,et al.  Estimated long-term ambient concentrations of PM10 and development of respiratory symptoms in a nonsmoking population. , 1995, Archives of environmental health.

[77]  Daniel Krewski,et al.  Lung Cancer and Cardiovascular Disease Mortality Associated with Ambient Air Pollution and Cigarette Smoke: Shape of the Exposure–Response Relationships , 2011, Environmental health perspectives.

[78]  Francesco Forastiere,et al.  Short-Term Effects of PM10 and NO2 on Respiratory Health among Children with Asthma or Asthma-like Symptoms: A Systematic Review and Meta-Analysis , 2009, Environmental health perspectives.