Key Elements in Determining Voriconazole Protein Binding Characteristics: Comment on "Determination of Plasma Unbound Fraction of Voriconazole in Patients Treated With a Prophylactic or a Curative Treatment".

cytes’ bone marrow regeneration after ribavirin-induced hemolysis. However, this regimen involves only 2 molecules. Thus, the antiviral efficacy of each molecule must be optimal. Ribavirin doses could be increased in patients who are more difficult to treat, by carefully monitoring ribavirin plasma concentrations. In fact, it would be a pity to lose the benefit of a highly effective molecule after stopping treatment, especially as ribavirin-induced anemia can be reduced by ensuring optimal ribavirin plasma concentrations. With these new treatment options available for certain patients, the question of cost-efficacy will become a major issue. Relapse remains the major problem concerning treatment of patients with sofosbuvir and ribavirin. It would be a great disadvantage to lose the benefit of effective molecules by nonoptimal monitoring of these patients during this short treatment period.