Mixing-models applied to industrial batch bioreactors

Mixing models for bioreactors on the basis of the tanks-in-series concept are presented and a suitable parameter-estimation method is introduced. The Monte-Carlo-optimization procedure with the inhomogeneity-curve included in the objective function is used. Results of the parameter optimization procedure are given for stirred-tank-bioreactors equipped with one and three Rushton turbines under aerated conditions. The model designed for the stirredtank with three Rushton turbines is capable to describe the mixing properties, while in case of the stirred-tank with one Rushton turbine the simulated radial circulation time does not correlate with the measured one.

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