Direct and Sensitive Determination of Atropine Sulfate at Polymer Electrode in Presence of Surface Active Agents

A novel, selective, rapid and simple electrochemical method is demonstrated for the first time for the determination of atropine sulfate, using poly (3, 4-ethylene-dioxythiophene) (PEDOT) electrode film modified platinum electrode in presence of sodium dodecyl sulfate (SDS). The modified electrode displays an obvious increase in the peak current (8 times) compared to the bare platinum electrode (Pt). The results indicate that PEDOT/Pt electrode in presence of SDS remarkably enhances the electrocatalytic activity towards the oxidation of Atropine sulfate. Cyclic voltammetry (CV), linear sweep voltammetry (LSV), and Electrochemical impedance spectroscopy (EIS) are used to verify the voltammetric behavior of Atropine sulfate in micelles media. Simultaneous determination of Atropine and morphine, and selective determination of atropine sulfate in presence of codeine, ascorbic acid and uric acid are obtained with high sensitivity and good resolution. The PEDOT/Pt in presence of SDS has also been successfully applied to the determination of Atropine sulfate in atropine sulfate injection in the linear ranges of 0.1 to 0.8 μmol L -1 and 2.5 to 100 μmol L -1 with low detection limits of 27 and 64 nM, respectively. The results indicate that the PEDOT/Pt electrode can successfully be applied for the analysis of pharmaceutics in biological fluids.