Differentiated thyroid tumors: surgical indications.

Thyroid gland tumors represent 1% of malignant tumors. In Italy their incidence is in constant growth. The aggressiveness depends on the histological type. The relative non-aggressive grade of different forms of tumors is the basis for discussing the treatment of choice: total thyroidectomy vs lobectomy with or without lymphadenectomy of the sixth level in the absence of metastasis. Authors report about their experience, and they advocate, given the high percentage of multicentric forms, total thyroidectomy as treatment of choice.

[1]  C. De Vito,et al.  Cervical lymph node metastases from thyroid cancer: does thyroglobulin and calcitonin measurement in fine needle aspirates improve the diagnostic value of cytology? , 2013, BMC Clinical Pathology.

[2]  F. Nardi,et al.  Diagnostic utility of thyroglobulin measurement in the fine needle aspirates from cervical lymph nodes: a case report. , 2012, Il Giornale di chirurgia.

[3]  M. Pelizzo,et al.  In papillary thyroid carcinoma BRAFV600E is associated with increased expression of the urokinase plasminogen activator 
and its cognate receptor, but not with disease‐free interval , 2012, Clinical endocrinology.

[4]  B. Kuru,et al.  The 2009 Revised American Thyroid Association Guidelines for Thyroid Cancer: the extent of surgery for thyroid carcinoma less than one and one half centimeters or low-risk thyroid carcinoma. , 2012, Thyroid : official journal of the American Thyroid Association.

[5]  B. Davidson,et al.  Patterns of Cervical Lymph Node Metastases in Primary and Recurrent Papillary Thyroid Cancer , 2011, Journal of oncology.

[6]  N. Avenia,et al.  Recurrent differentiated thyroid cancer: to cut or burn , 2011, World journal of surgical oncology.

[7]  Roy Phitayakorn,et al.  Follicular adenoma and carcinoma of the thyroid gland. , 2011, The oncologist.

[8]  Rebeccah L. Brown,et al.  Thyroid Cancer: Burden of Illness and Management of Disease , 2011, Journal of Cancer.

[9]  A. González-González,et al.  New guidelines for the management of thyroid nodules and differentiated thyroid cancer. , 2011, Minerva endocrinologica.

[10]  L. Frati,et al.  High expression of the urokinase plasminogen activator and its cognate receptor associates with advanced stages and reduced disease-free interval in papillary thyroid carcinoma. , 2011, The Journal of clinical endocrinology and metabolism.

[11]  L. Lester,et al.  Central nodal metastases in papillary thyroid carcinoma based on tumor histologic type and focality. , 2010, Archives of otolaryngology--head & neck surgery.

[12]  M. Santoro,et al.  Insights into the molecular function of the inactivating mutations of B-Raf involving the DFG motif. , 2009, Biochimica et biophysica acta.

[13]  T. Fahey,et al.  Papillary thyroid carcinoma and microcarcinoma: is there a need to distinguish the two? , 2009, Thyroid : official journal of the American Thyroid Association.

[14]  A. Pinchera,et al.  [Diagnostic, therapeutic and healthcare management protocols in thyroid surgery. 2nd Consensus Conference (U.E.C. CLUB)]. , 2009, Il Giornale di chirurgia.

[15]  M. Hočevar,et al.  Extent of Thyroidectomy and Lymphadenectomy in 254 Patients With Papillary Thyroid Microcarcinoma: A Single-Institution Experience , 2009, Annals of Surgical Oncology.

[16]  E. Puxeddu,et al.  Recurrences of thyroid well differentiated cancer: ultrasonography-guided surgical treatment. , 2008, Minerva chirurgica.

[17]  S. Filetti,et al.  Clinical implications of BRAF mutation in thyroid carcinoma , 2008, Trends in Endocrinology & Metabolism.

[18]  E. Puxeddu,et al.  Identification of differentially expressed proteins in papillary thyroid carcinomas with V600E mutation of BRAF , 2007, Proteomics. Clinical applications.

[19]  S. Filetti,et al.  BRAF mutations in papillary thyroid carcinomas inhibit genes involved in iodine metabolism. , 2007, The Journal of clinical endocrinology and metabolism.

[20]  A. Pinchera,et al.  Correlation between B-RAFV600E mutation and clinico-pathologic parameters in papillary thyroid carcinoma: data from a multicentric Italian study and review of the literature. , 2006, Endocrine-related cancer.

[21]  M. Tartaglia,et al.  Genotyping of an Italian papillary thyroid carcinoma cohort revealed high prevalence of BRAF mutations, absence of RAS mutations and allowed the detection of a new mutation of BRAF oncoprotein (BRAFV599Ins) , 2006, Clinical endocrinology.

[22]  V. D’Andrea,et al.  Prognostic Importance of Histologic Vascular Invasion in Papillary Thyroid Carcinoma , 2005, Annals of surgery.

[23]  V. D’Andrea,et al.  Prognostic significance of the age factor in the thyroid cancer: Statistical analysis , 2004, Journal of surgical oncology.

[24]  A. Pinchera,et al.  BRAFV599E Mutation Is the Leading Genetic Event in Adult Sporadic Papillary Thyroid Carcinomas , 2004 .

[25]  P. Bernante,et al.  Complications of Thyroid Surgery: Analysis of a Multicentric Study on 14,934 Patients Operated on in Italy over 5 Years , 2004, World Journal of Surgery.

[26]  V. D’Andrea,et al.  Papillary microcarcinoma of the thyroid gland: analysis of prognostic factors including histological subtype. , 2003, The European journal of surgery. Supplement. : = Acta chirurgica. Supplement.

[27]  R. Ribacchi,et al.  Ret/PTC activation does not influence clinical and pathological features of adult papillary thyroid carcinomas. , 2003, European journal of endocrinology.

[28]  E. Bergstralh,et al.  Predicting outcome in papillary thyroid carcinoma: development of a reliable prognostic scoring system in a cohort of 1779 patients surgically treated at one institution during 1940 through 1989. , 1993, Surgery.

[29]  O. Clark.  Total thyroidectomy: The Treatment of Choice for patients With Differentiated Thyroid Cancer , 1982, Annals of surgery.

[30]  E. Mazzaferri,et al.  Papillary thyroid carcinoma: a 10 year follow-up report of the impact of therapy in 576 patients. , 1981, The American journal of medicine.

[31]  A. Shaha.  Advances in the management of thyroid cancer. , 2005, International journal of surgery.

[32]  Nicola Avenia,et al.  Il trattamento chirurgico del cancro della tiroide:analisi di 207 casi trattati , 1999 .