Micellar properties of drugs: micellar and nonmicellar patterns of self-association of hydrophobic solutes of different molecular structures--monomer fraction, availability, and misuses of micellar hypothesis.

Abstract The nature of multiple, sequential, self-association equilibria and the significance of the average degrees of association are discussed. Characteristic patterns of association are examined on the basis of available experimental evidence and suitable theoretical models of self-association and their relationship to molecular structure is indicated. The meaning and significance of the simple two-phase approximation of the micellar hypothesis to the cmC are examined and its application is discussed.

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