Germinal center B cell maintenance and differentiation are controlled by distinct NF-κB transcription factor subunits

Heise et al. find that the NF-κB subunits c-REL and RELA in B cells play distinct roles during the germinal center reaction. While RELA stimulates the emergence of plasma cells from the germinal center, c-REL supports maintenance of the reaction over time, possibly by inducing a metabolic gene program connected to cell proliferation.

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