Lgr5+ stem cells are indispensable for radiation-induced intestinal regeneration.

[1]  J. Geng,et al.  Induction of intestinal stem cells by R-spondin 1 and Slit2 augments chemoradioprotection , 2013, Nature.

[2]  Yunhua Zhu,et al.  Apoptosis differently affects lineage tracing of Lgr5 and Bmi1 intestinal stem cell populations. , 2013, Cell stem cell.

[3]  R. Russell,et al.  Intestinal label-retaining cells are secretory precursors expressing Lgr5 , 2013, Nature.

[4]  J. Pačes,et al.  Troy, a tumor necrosis factor receptor family member, interacts with lgr5 to inhibit wnt signaling in intestinal stem cells. , 2013, Gastroenterology.

[5]  J. Utikal,et al.  Dose-dependent roles for canonical Wnt signalling in de novo crypt formation and cell cycle properties of the colonic epithelium , 2013, Journal of Cell Science.

[6]  H. Clevers,et al.  BASIC AND TRANSLATIONAL — ALIMENTARY TRACT Crypt Base Columnar Stem Cells in Small Intestines of Mice Are Radioresistant , 2012 .

[7]  Alexander van Oudenaarden,et al.  Identifying the stem cell of the intestinal crypt: strategies and pitfalls. , 2012, Cell stem cell.

[8]  A. Oudenaarden,et al.  Dll1+ secretory progenitor cells revert to stem cells upon crypt damage , 2012, Nature Cell Biology.

[9]  Alexander van Oudenaarden,et al.  The Lgr5 Intestinal Stem Cell Signature: Robust Expression of Proposed Quiescent ' Þ 4' Cell Markers , 2022 .

[10]  Franck Letourneur,et al.  Functional intestinal stem cells after Paneth cell ablation induced by the loss of transcription factor Math1 (Atoh1) , 2012, Proceedings of the National Academy of Sciences.

[11]  Dudley Lamming,et al.  mTORC1 in the Paneth cell niche couples intestinal stem cell function to calorie intake , 2012, Nature.

[12]  Bruce J. Aronow,et al.  The Pan-ErbB Negative Regulator Lrig1 Is an Intestinal Stem Cell Marker that Functions as a Tumor Suppressor , 2012, Cell.

[13]  Julia B. Cordero,et al.  Wnt signalling and its role in stem cell‐driven intestinal regeneration and hyperplasia , 2012, Acta physiologica.

[14]  M. Capecchi,et al.  The intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populations , 2011, Proceedings of the National Academy of Sciences.

[15]  J. Epstein,et al.  Interconversion Between Intestinal Stem Cell Populations in Distinct Niches , 2011, Science.

[16]  O. Klein,et al.  A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable , 2011, Nature.

[17]  Hans Clevers,et al.  Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts , 2011, Nature.

[18]  E. Passegué,et al.  DNA-damage response in tissue-specific and cancer stem cells. , 2011, Cell stem cell.

[19]  Camilla A. Richmond,et al.  Mouse telomerase reverse transcriptase (mTert) expression marks slowly cycling intestinal stem cells , 2010, Proceedings of the National Academy of Sciences.

[20]  Julie A. Wilkins,et al.  Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling. , 2010, Developmental cell.

[21]  C. Guha,et al.  Protective Role of R-spondin1, an Intestinal Stem Cell Growth Factor, against Radiation-Induced Gastrointestinal Syndrome in Mice , 2009, PloS one.

[22]  M. Loeffler,et al.  The stem cells of small intestinal crypts: where are they? , 2009, Cell proliferation.

[23]  H. Clevers,et al.  Single Lgr5 stem cells build crypt–villus structures in vitro without a mesenchymal niche , 2009, Nature.

[24]  H. Clevers,et al.  Stem cells, self-renewal, and differentiation in the intestinal epithelium. , 2009, Annual review of physiology.

[25]  Hans Clevers,et al.  Crypt stem cells as the cells-of-origin of intestinal cancer , 2009, Nature.

[26]  M. Capecchi,et al.  Bmi1 is expressed in vivo in intestinal stem cells , 2008, Nature Genetics.

[27]  H. Clevers,et al.  Identification of stem cells in small intestine and colon by marker gene Lgr5 , 2007, Nature.

[28]  Jennifer J. Lund,et al.  Adenomatous Polyposis Coli (APC) Is Required for Normal Development of Skin and Thymus , 2006, PLoS genetics.

[29]  Takeshi Oshima,et al.  Mitogenic Influence of Human R-Spondin1 on the Intestinal Epithelium , 2005, Science.

[30]  Louise Howard,et al.  Cellular inheritance of a Cre‐activated reporter gene to determine paneth cell longevity in the murine small intestine , 2005, Developmental dynamics : an official publication of the American Association of Anatomists.

[31]  T. Möröy,et al.  Gfi1:Green Fluorescent Protein Knock-in Mutant Reveals Differential Expression and Autoregulation of the Growth Factor Independence 1 (Gfi1) Gene during Lymphocyte Development* , 2004, Journal of Biological Chemistry.

[32]  Ian P Newton,et al.  Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration. , 2004, Genes & development.

[33]  C. Potten Radiation, the Ideal Cytotoxic Agent for Studying the Cell Biology of Tissues such as the Small Intestine1 , 2004, Radiation research.

[34]  C. Potten,et al.  The intestinal epithelial stem cell: the mucosal governor , 1997, International journal of experimental pathology.

[35]  C J Kemp,et al.  The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice. , 1994, Cancer research.

[36]  C. Potten,et al.  Extreme sensitivity of some intestinal crypt cells to X and γ irradiation , 1977, Nature.

[37]  C. P. Leblond,et al.  Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. V. Unitarian Theory of the origin of the four epithelial cell types. , 1974, The American journal of anatomy.

[38]  Christopher S Potten,et al.  The intestinal epithelial stem cell. , 2002, BioEssays : news and reviews in molecular, cellular and developmental biology.

[39]  T. Ohkusa,et al.  A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice. , 1990, Gastroenterology.

[40]  C. Potten Extreme sensitivity of some intestinal crypt cells to X and gamma irradiation. , 1977, Nature.

[41]  H Cheng,et al.  Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. II. Mucous cells. , 1974, The American journal of anatomy.

[42]  H. Withers,et al.  Microcolony survival assay for cells of mouse intestinal mucosa exposed to radiation. , 1970, International journal of radiation biology and related studies in physics, chemistry, and medicine.