Looking for Drugs in All the Wrong Places: Use of GCPII Inhibitors Outside the Brain
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[1] 程超,et al. 68 Ga-PSMA-11 PET-CT与全身磁共振成像诊断前列腺癌远处转移的效能比较 , 2021 .
[2] B. Slusher,et al. Enhanced oral bioavailability of 2-(phosphonomethyl)-pentanedioic acid (2-PMPA) from its (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl (ODOL) based prodrugs. , 2019, Molecular pharmaceutics.
[3] D. Mahalingam,et al. A Phase II, Multicenter, Single-Arm Study of Mipsagargin (G-202) as a Second-Line Therapy Following Sorafenib for Adult Patients with Progressive Advanced Hepatocellular Carcinoma , 2019, Cancers.
[4] U. Lützen,et al. Experimental 177Lu-PSMA-617 radioligand therapy in a patient with extended metastasized leiomyosarcoma , 2019, Nuklearmedizin.
[5] S. Marie,et al. Uncovering the Role of N-Acetyl-Aspartyl-Glutamate as a Glutamate Reservoir in Cancer , 2019, Cell reports.
[6] P. Albers,et al. Prospective comparison of whole-body MRI and 68Ga-PSMA PET/CT for the detection of biochemical recurrence of prostate cancer after radical prostatectomy , 2019, European Journal of Nuclear Medicine and Molecular Imaging.
[7] C. Uprimny. 68Ga-PSMA-11 PET/CT: the rising star of nuclear medicine in prostate cancer imaging? , 2019, Wiener Medizinische Wochenschrift.
[8] A. Paschali,et al. Rib Fractures Mimicking Bone Metastases in 18F-PSMA-1007 PET/CT for Prostate Cancer. , 2019, Clinical nuclear medicine.
[9] K. Lemberg,et al. We're Not “DON” Yet: Optimal Dosing and Prodrug Delivery of 6-Diazo-5-oxo-L-norleucine , 2018, Molecular Cancer Therapeutics.
[10] Matthias Eiber,et al. 68Ga-PSMA-HBED-CC Uptake in Cervical, Celiac, and Sacral Ganglia as an Important Pitfall in Prostate Cancer PET Imaging , 2018, The Journal of Nuclear Medicine.
[11] J. Kotzerke,et al. Prostate-Specific Membrane Antigen Expression in Distal Radius Fracture. , 2018, Clinical nuclear medicine.
[12] D. O’Keefe,et al. A Perspective on the Evolving Story of PSMA Biology, PSMA-Based Imaging, and Endoradiotherapeutic Strategies , 2018, The Journal of Nuclear Medicine.
[13] Rajender Kumar,et al. Synchronous Detection of Male Breast Cancer and Prostatic Cancer in a Patient With Suspected Prostatic Carcinoma on 68Ga-PSMA PET/CT Imaging. , 2018, Clinical nuclear medicine.
[14] G. Arora,et al. 68Ga-Prostate-Specific Membrane Antigen PET/CT in Triple-Negative Breast Cancer. , 2018, Clinical nuclear medicine.
[15] D. Murphy,et al. [177Lu]-PSMA-617 radionuclide treatment in patients with metastatic castration-resistant prostate cancer (LuPSMA trial): a single-centre, single-arm, phase 2 study. , 2018, The Lancet. Oncology.
[16] U. Haberkorn,et al. PSMA-Targeted Radionuclide Therapy and Salivary Gland Toxicity: Why Does It Matter? , 2018, The Journal of Nuclear Medicine.
[17] U. Haberkorn,et al. Targeted α-Therapy of Metastatic Castration-Resistant Prostate Cancer with 225Ac-PSMA-617: Swimmer-Plot Analysis Suggests Efficacy Regarding Duration of Tumor Control , 2018, The Journal of Nuclear Medicine.
[18] G. Kristiansen,et al. Prostate-specific membrane antigen in breast cancer: a comprehensive evaluation of expression and a case report of radionuclide therapy , 2018, Breast Cancer Research and Treatment.
[19] K. Rahbar,et al. Targeting PSMA by radioligands in non-prostate disease—current status and future perspectives , 2018, European Journal of Nuclear Medicine and Molecular Imaging.
[20] H. Hieronymus,et al. Prostate-specific membrane antigen cleavage of vitamin B9 stimulates oncogenic signaling through metabotropic glutamate receptors , 2018, The Journal of experimental medicine.
[21] Alexander Haug,et al. Current status of theranostics in prostate cancer , 2017, European Journal of Nuclear Medicine and Molecular Imaging.
[22] T. Joensuu,et al. Third-line treatment and 177Lu-PSMA radioligand therapy of metastatic castration-resistant prostate cancer: a systematic review , 2017, European Journal of Nuclear Medicine and Molecular Imaging.
[23] K. Miles,et al. Subacute Cerebellar Infarction With Uptake on 68Ga-Prostate-Specific Membrane Antigen PET/CT. , 2017, Clinical nuclear medicine.
[24] G. Lenz,et al. Prostate specific membrane antigen (PSMA) expression in non-small cell lung cancer , 2017, PloS one.
[25] Martin C. Wright,et al. Synthesis and Biologic Evaluation of a Novel 18F-Labeled Adnectin as a PET Radioligand for Imaging PD-L1 Expression , 2017, The Journal of Nuclear Medicine.
[26] L. Ensign,et al. Local enema treatment to inhibit FOLH1/GCPII as a novel therapy for inflammatory bowel disease , 2017, Journal of controlled release : official journal of the Controlled Release Society.
[27] Steven P Rowe,et al. Prostate-Specific Membrane Antigen Ligands for Imaging and Therapy , 2017, The Journal of Nuclear Medicine.
[28] B. Slusher,et al. Enhanced Brain Delivery of 2-(Phosphonomethyl)pentanedioic Acid Following Intranasal Administration of Its γ-Substituted Ester Prodrugs. , 2017, Molecular pharmaceutics.
[29] G. Antoch,et al. Evaluation of Practical Interpretation Hurdles in 68Ga-PSMA PET/CT in 55 Patients: Physiological Tracer Distribution and Incidental Tracer Uptake , 2017, Clinical nuclear medicine.
[30] R. Mansberg,et al. Incidental Prostate-Specific Membrane Antigen Uptake in a Peripheral Nerve Sheath Tumor. , 2017, Clinical nuclear medicine.
[31] Matthias Eiber,et al. 177Lu-PSMA Radioligand Therapy for Prostate Cancer , 2017, The Journal of Nuclear Medicine.
[32] H. Zacho,et al. 68Ga-PSMA PET/CT Uptake in Intramuscular Myxoma Imitates Prostate Cancer Metastasis. , 2017, Clinical nuclear medicine.
[33] H. Demir,et al. Uptake of an Acrochordon Incidentally Detected on 68Ga Prostate-Specific Membrane Antigen PET/CT. , 2017, Clinical nuclear medicine.
[34] Koen Van Laere,et al. Fibrous dysplasia mimicking bone metastasis on 68GA-PSMA PET/MRI , 2017, European Journal of Nuclear Medicine and Molecular Imaging.
[35] W. Weichert,et al. Targeted α-Therapy of Metastatic Castration-Resistant Prostate Cancer with 225Ac-PSMA-617: Dosimetry Estimate and Empiric Dose Finding , 2017, The Journal of Nuclear Medicine.
[36] Johan De Mey,et al. PSMA Uptake in Mediastinal Sarcoidosis. , 2017, Clinical nuclear medicine.
[37] E. Hsiao,et al. Subacute Cortical Infarct Showing Uptake on 68Ga-PSMA PET/CT. , 2017, Clinical nuclear medicine.
[38] W. Brenner,et al. German Multicenter Study Investigating 177Lu-PSMA-617 Radioligand Therapy in Advanced Prostate Cancer Patients , 2017, Journal of Nuclear Medicine.
[39] B. Slusher,et al. Still NAAG'ing After All These Years: The Continuing Pursuit of GCPII Inhibitors. , 2016, Advances in pharmacology.
[40] K. Rahbar,et al. Expression of PSMA in tumor neovasculature of high grade sarcomas including synovial sarcoma, rhabdomyosarcoma, undifferentiated sarcoma and MPNST , 2016, Oncotarget.
[41] P. Choyke,et al. PSMA PET and Radionuclide Therapy in Prostate Cancer. , 2016, Seminars in nuclear medicine.
[42] A. Sasikumar,et al. Radiolabeled enzyme inhibitors and binding agents targeting PSMA: Effective theranostic tools for imaging and therapy of prostate cancer. , 2016, Nuclear medicine and biology.
[43] R. Bohle,et al. Prostate-specific membrane antigen (PSMA) expression in breast cancer and its metastases , 2017, Clinical & Experimental Metastasis.
[44] T. Maurer,et al. 68Ga-PSMA PET/MR Showing Intense PSMA Uptake in Nodular Fasciitis Mimicking Prostate Cancer Metastasis. , 2016, Clinical nuclear medicine.
[45] U. Haberkorn,et al. The Rise of PSMA Ligands for Diagnosis and Therapy of Prostate Cancer , 2016, The Journal of Nuclear Medicine.
[46] A. Sasikumar,et al. 68Ga-PSMA PET/CT False-Positive Tracer Uptake in Paget Disease. , 2016, Clinical nuclear medicine.
[47] K. Rahbar,et al. Subacute Stroke Mimicking Cerebral Metastasis in 68Ga-PSMA-HBED-CC PET/CT. , 2016, Clinical nuclear medicine.
[48] Sait Sağer,et al. Incidental Detection of Follicular Thyroid Carcinoma in 68Ga-PSMA PET/CT Imaging , 2016, The Journal of Nuclear Medicine Technology.
[49] M. Marohn,et al. FOLH1/GCPII is elevated in IBD patients, and its inhibition ameliorates murine IBD abnormalities. , 2016, JCI insight.
[50] U. Haberkorn,et al. PSMA-Targeted Radionuclide Therapy of Metastatic Castration-Resistant Prostate Cancer with 177Lu-Labeled PSMA-617 , 2016, The Journal of Nuclear Medicine.
[51] M. Ghosh,et al. Prostate-specific membrane antigen (PSMA)-mediated laminin proteolysis generates a pro-angiogenic peptide , 2016, Angiogenesis.
[52] Lode Goethals,et al. Healing Sacral Fracture Masquerading as Metastatic Bone Disease on a 68Ga-PSMA PET/CT. , 2016, Clinical nuclear medicine.
[53] T. Eade,et al. Desmoid Tumor Showing Intense Uptake on 68Ga PSMA-HBED-CC PET/CT. , 2016, Clinical nuclear medicine.
[54] C. Bal,et al. PSMA Expression in Papillary Thyroid Carcinoma: Opening a New Horizon in Management of Thyroid Cancer? , 2016, Clinical nuclear medicine.
[55] O. Boerman,et al. Towards Personalized Treatment of Prostate Cancer: PSMA I&T, a Promising Prostate-Specific Membrane Antigen-Targeted Theranostic Agent , 2016, Theranostics.
[56] Markus Schwaiger,et al. Current use of PSMA–PET in prostate cancer management , 2016, Nature Reviews Urology.
[57] D. Maintz,et al. Prostate-Specific Membrane Antigen PET/CT in Splenic Sarcoidosis. , 2015, Clinical nuclear medicine.
[58] E. Demirci,et al. Pre-therapeutic dosimetry of normal organs and tissues of 177Lu-PSMA-617 prostate-specific membrane antigen (PSMA) inhibitor in patients with castration-resistant prostate cancer , 2015, European Journal of Nuclear Medicine and Molecular Imaging.
[59] A. Sawa,et al. Selective CNS Uptake of the GCP-II Inhibitor 2-PMPA following Intranasal Administration , 2015, PloS one.
[60] Yi Pan,et al. Expression of Prostate-Specific Membrane Antigen in Lung Cancer Cells and Tumor Neovasculature Endothelial Cells and Its Clinical Significance , 2015, PloS one.
[61] F. Mottaghy,et al. First evidence of PSMA expression in differentiated thyroid cancer using [68Ga]PSMA-HBED-CC PET/CT , 2015, European Journal of Nuclear Medicine and Molecular Imaging.
[62] U. Haberkorn,et al. PMPA for Nephroprotection in PSMA-Targeted Radionuclide Therapy of Prostate Cancer , 2015, The Journal of Nuclear Medicine.
[63] J. Konvalinka,et al. Structural and biochemical characterization of the folyl‐poly‐γ‐l‐glutamate hydrolyzing activity of human glutamate carboxypeptidase II , 2014, The FEBS journal.
[64] B. Ristau,et al. The prostate-specific membrane antigen: lessons and current clinical implications from 20 years of research. , 2014, Urologic oncology.
[65] S. Pastorino,et al. Prostate specific membrane antigen (PSMA) expression in primary gliomas and breast cancer brain metastases , 2014, Cancer Cell International.
[66] B. Hadaschik,et al. Radiation dosimetry and first therapy results with a 124I/131I-labeled small molecule (MIP-1095) targeting PSMA for prostate cancer therapy , 2014, European Journal of Nuclear Medicine and Molecular Imaging.
[67] Huan Zhang,et al. Prostate-specific membrane antigen as a marker of pancreatic cancer cells , 2014, Medical Oncology.
[68] S. Ben-Shachar,et al. Gene Expression Profiles of Ileal Inflammatory Bowel Disease Correlate with Disease Phenotype and Advance Understanding of Its Immunopathogenesis , 2013, Inflammatory bowel diseases.
[69] L. Shapiro,et al. Prostate specific membrane antigen produces pro-angiogenic laminin peptides downstream of matrix metalloprotease-2 , 2013, Angiogenesis.
[70] T. Holland-Letz,et al. PET imaging with a [68Ga]gallium-labelled PSMA ligand for the diagnosis of prostate cancer: biodistribution in humans and first evaluation of tumour lesions , 2013, European Journal of Nuclear Medicine and Molecular Imaging.
[71] T. Dassopoulos,et al. An Ileal Crohn's Disease Gene Signature Based on Whole Human Genome Expression Profiles of Disease Unaffected Ileal Mucosal Biopsies , 2012, PloS one.
[72] J. Konvalinka,et al. GCPII variants, paralogs and orthologs. , 2012, Current medicinal chemistry.
[73] M. Pomper,et al. Glutamate carboxypeptidase II in diagnosis and treatment of neurologic disorders and prostate cancer. , 2012, Current medicinal chemistry.
[74] Jack Satsangi,et al. Characterization of intestinal gene expression profiles in Crohn's disease by genome‐wide microarray analysis , 2010, Inflammatory bowel diseases.
[75] J. Konvalinka,et al. Structural insight into the evolutionary and pharmacologic homology of glutamate carboxypeptidases II and III , 2009, The FEBS journal.
[76] Victor E Reuter,et al. Prostate-specific membrane antigen expression in regeneration and repair , 2008, Modern Pathology.
[77] G. V. van Leenders,et al. Histopathological and immunohistochemical characterization of canine prostate cancer , 2008, The Prostate.
[78] J. McArthur,et al. Denervation of skin in neuropathies: the sequence of axonal and Schwann cell changes in skin biopsies. , 2007, Brain : a journal of neurology.
[79] S. Vollset,et al. Relations of glutamate carboxypeptidase II (GCPII) polymorphisms to folate and homocysteine concentrations and to scores of cognition, anxiety, and depression in a homogeneous Norwegian population: the Hordaland Homocysteine Study. , 2007, The American journal of clinical nutrition.
[80] Rolf Hilgenfeld,et al. Human glutamate carboxypeptidase II inhibition: structures of GCPII in complex with two potent inhibitors, quisqualate and 2-PMPA. , 2007, Acta crystallographica. Section D, Biological crystallography.
[81] J. Konvalinka,et al. A high-resolution structure of ligand-free human glutamate carboxypeptidase II. , 2007, Acta crystallographica. Section F, Structural biology and crystallization communications.
[82] Dianqing Wu,et al. Prostate-Specific Membrane Antigen Regulates Angiogenesis by Modulating Integrin Signal Transduction , 2006, Molecular and Cellular Biology.
[83] S. Landas,et al. Expression of Prostate-Specific Membrane Antigen in Normal and Malignant Human Tissues , 2006, World Journal of Surgery.
[84] A. Devlin,et al. Interactions among polymorphisms in folate-metabolizing genes and serum total homocysteine concentrations in a healthy elderly population. , 2006, The American journal of clinical nutrition.
[85] D. Hilt,et al. The central nervous system effects, pharmacokinetics and safety of the NAALADase-inhibitor GPI 5693. , 2005, British journal of clinical pharmacology.
[86] D. Hunter,et al. Polymorphisms in the one‐carbon metabolic pathway, plasma folate levels and colorectal cancer in a prospective study , 2004, International journal of cancer.
[87] H. Blom,et al. Influence of a glutamate carboxypeptidase II (GCPII) polymorphism (1561C-->T) on plasma homocysteine, folate and vitamin B(12) levels and its relationship to cardiovascular disease risk. , 2002, Atherosclerosis.
[88] P. Wilson,et al. The glutamate carboxypeptidase gene II (C>T) polymorphism does not affect folate status in the Framingham Offspring cohort. , 2002, The Journal of nutrition.
[89] A. D. Smith,et al. Glutamate carboxypeptidase II: a polymorphism associated with lower levels of serum folate and hyperhomocysteinemia. , 2000, Human molecular genetics.
[90] I. Black,et al. Glutamate carboxypeptidase II is expressed by astrocytes in the adult rat nervous system , 1999, The Journal of comparative neurology.
[91] F. Tortella,et al. Selective inhibition of NAALADase, which converts NAAG to glutamate, reduces ischemic brain injury , 1999, Nature Medicine.
[92] V. Reuter,et al. Five different anti-prostate-specific membrane antigen (PSMA) antibodies confirm PSMA expression in tumor-associated neovasculature. , 1999, Cancer research.
[93] J. Coyle,et al. Hydrolysis of the neuropeptide N-acetylaspartylglutamate (NAAG) by cloned human glutamate carboxypeptidase II 1 Published on the World Wide Web on 24 April 1998. 1 , 1998, Brain Research.
[94] J. Coyle,et al. Isolation and expression of a rat brain cDNA encoding glutamate carboxypeptidase II. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[95] J. Neale,et al. Molecular Cloning of a Peptidase Against N‐Acetylaspartylglutamate from a Rat Hippocampal cDNA Library , 1997, Journal of neurochemistry.
[96] N. Bander,et al. Monoclonal antibodies to the extracellular domain of prostate-specific membrane antigen also react with tumor vascular endothelium. , 1997, Cancer research.
[97] B. Suffoletto,et al. Prostate-specific membrane antigen: a novel folate hydrolase in human prostatic carcinoma cells. , 1996, Clinical cancer research : an official journal of the American Association for Cancer Research.
[98] J. Coyle,et al. Prostate-specific membrane antigen is a hydrolase with substrate and pharmacologic characteristics of a neuropeptidase. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[99] L. E. Ross,et al. Design, synthesis, and biological activity of a potent inhibitor of the neuropeptidase N-acetylated alpha-linked acidic dipeptidase. , 1996, Journal of medicinal chemistry.
[100] George L. Wright,et al. Detection and characterization of the prostate‐specific membrane antigen (PSMA) in tissue extracts and body fluids , 1995, International journal of cancer.
[101] J. Coyle,et al. N-acetylated alpha-linked acidic dipeptidase is expressed by non-myelinating Schwann cells in the peripheral nervous system , 1995, Journal of neurocytology.
[102] W. Fair,et al. Expression of the prostate-specific membrane antigen. , 1994, Cancer research.
[103] W. Fair,et al. Molecular cloning of a complementary DNA encoding a prostate-specific membrane antigen. , 1993, Cancer research.
[104] J. Coyle,et al. Immunocytochemical localization of the N‐acetyl‐aspartyl‐glutamate (NAAG) hydrolyzing enzyme N‐acetylated α‐linked acidic dipeptidase (NAALADase) , 1992, The Journal of comparative neurology.
[105] J. Coyle,et al. Rat brain N-acetylated alpha-linked acidic dipeptidase activity. Purification and immunologic characterization. , 1990, The Journal of biological chemistry.
[106] J. Coyle,et al. Hydrolysis of the Brain Dipeptide N‐Acetyl‐l‐Aspartyl‐l‐Glutamate: Subcellular and Regional Distribution, Ontogeny, and the Effect of Lesions on N‐Acetylated‐α‐Linked Acidic Dipeptidase Activity , 1988, Journal of neurochemistry.
[107] J. Coyle,et al. Hydrolysis of the brain dipeptide N-acetyl-L-aspartyl-L-glutamate. Identification and characterization of a novel N-acetylated alpha-linked acidic dipeptidase activity from rat brain. , 1987, The Journal of biological chemistry.
[108] J. Coyle,et al. Quisqualate selectively inhibits a brain peptidase which cleaves N-acetyl-L-aspartyl-L-glutamate in vitro. , 1986, European journal of pharmacology.
[109] J. Coyle,et al. N-Acetylaspartylglutamate: possible role as the neurotransmitter of the lateral olfactory tract. , 1985, Proceedings of the National Academy of Sciences of the United States of America.
[110] B. Shane,et al. Availability of monoglutamyl and polyglutamyl folates in normal subjects and in patients with coeliac sprue. , 1978, Gut.
[111] C. Butterworth,et al. Jejunal perfusion of simple and conjugated folates in man. , 1975, Gastroenterology.
[112] L. Fry,et al. Malabsorption of Dietary Folate (Pteroylpolyglutamates) in Adult Coeliac Disease and Dermatitis Herpetiformis , 1970, British medical journal.
[113] K. Bouchelouche,et al. 68Ga-PSMA Uptake in Anal Fistula on PET/CT Scan. , 2019, Clinical nuclear medicine.
[114] K. Rahbar,et al. Lu-PSMA Radioligand Therapy for Prostate Cancer , 2017 .
[115] Kratochwil Clemens,et al. Targeted Alpha Therapy of mCRPC with 225Actinium-PSMA-617: Dosimetry estimate and empirical dose finding , 2017 .
[116] R. Velthoven,et al. Paget bone disease demonstrated on 68Ga-PSMA ligand PET/CT , 2015, European Journal of Nuclear Medicine and Molecular Imaging.
[117] M. Schwaiger,et al. Intense PSMA-expression using 68Ga-PSMA PET/CT in a paravertebral schwannoma mimicking prostate cancer metastasis , 2015, European Journal of Nuclear Medicine and Molecular Imaging.
[118] U. Haberkorn,et al. Dosimetry for 177Lu-DKFZ-PSMA-617: a new radiopharmaceutical for the treatment of metastatic prostate cancer , 2015, European Journal of Nuclear Medicine and Molecular Imaging.
[119] G. Tabatabai,et al. In vivo visualization of prostate-specific membrane antigen in glioblastoma , 2014, European Journal of Nuclear Medicine and Molecular Imaging.
[120] J. A. Dar,et al. Combined impact of polymorphism of folate metabolism genes; glutamate carboxypeptidase, methylene tetrahydrofolate reductase and methionine synthase reductase on breast cancer susceptibility in kashmiri women. , 2008, International journal of health sciences.
[121] H. Blom,et al. The H475Y polymorphism in the glutamate carboxypeptidase II gene increases plasma folate without affecting the risk for neural tube defects in humans. , 2003, The Journal of nutrition.
[122] C. Cordon-Cardo,et al. Prostate-specific membrane antigen expression in normal and malignant human tissues. , 1997, Clinical cancer research : an official journal of the American Association for Cancer Research.
[123] G. Murphy,et al. Immunoscintigraphy of prostatic cancer: Preliminary results with 111in‐labeled monoclonal antibody 7E11‐C5.3 (CYT‐356) , 1991, The Prostate.
[124] G. Murphy,et al. Monoclonal antibodies to a new antigenic marker in epithelial prostatic cells and serum of prostatic cancer patients. , 1987, Anticancer research.
[125] J. Coyle,et al. Acidic peptides in brain: do they act at putative glutamatergic synapses? , 1986, Advances in experimental medicine and biology.