An electrostatically actuated cantilever device capable of accurately calibrating the cantilever on-chip for AFM-like applications

We present the principle of an electrostatically actuated cantilever device that can calibrate the cantilever stiffness on-chip with uncertainties in the range of ±5%. The calibration procedure is quick, simple and non-destructive. The device can be fabricated using routine micromachining techniques and be easily made compatible with commercially available atomic force microscopes (AFMs). The electrostatic actuation makes the device quite versatile. In addition to the usual AFM-like applications, the device can also be used for mass-sensing applications as well as an effective interfacial force microscope.

[1]  J. Zlatanova,et al.  Single molecule force spectroscopy in biology using the atomic force microscope. , 2000, Progress in biophysics and molecular biology.

[2]  M C Davies,et al.  Measuring and visualizing single molecular interactions in biology. , 2003, Biochemical Society transactions.

[3]  P. Hansma,et al.  A nondestructive method for determining the spring constant of cantilevers for scanning force microscopy , 1993 .

[4]  Elliott R. Brown,et al.  RF-MEMS switches for reconfigurable integrated circuits , 1998 .

[5]  F. Mendels,et al.  Dynamic properties of AFM cantilevers and the calibration of their spring constants , 2006 .

[6]  John W. Suh,et al.  CMOS integrated ciliary actuator array as a general-purpose micromanipulation tool for small objects , 1999 .

[7]  John Bechhoefer,et al.  Measurement and manipulation of van der Waals forces in atomic‐force microscopy , 1994 .

[8]  J. Bechhoefer,et al.  Calibration of atomic‐force microscope tips , 1993 .

[9]  B. Auld,et al.  Acoustic fields and waves in solids , 1973 .

[10]  M C Davies,et al.  Detection of antigen-antibody binding events with the atomic force microscope. , 1997, Biochemistry.

[11]  Tilman E. Schäffer,et al.  Force spectroscopy with a large dynamic range using small cantilevers and an array detector , 2002 .

[12]  Benjamin Ohler,et al.  Cantilever spring constant calibration using laser Doppler vibrometry. , 2007, The Review of scientific instruments.

[13]  C. Daniel Frisbie,et al.  Direct Force Measurements at Polymer Brush Surfaces by Atomic Force Microscopy , 1998 .

[14]  V. Dupres,et al.  Probing molecular recognition sites on biosurfaces using AFM. , 2007, Biomaterials.

[15]  R. Colton,et al.  Measuring the nanomechanical properties and surface forces of materials using an atomic force microscope , 1989 .

[16]  J. Sader,et al.  Method for the calibration of atomic force microscope cantilevers , 1995 .

[17]  Y. Dufrêne Application of atomic force microscopy to microbial surfaces: from reconstituted cell surface layers to living cells. , 2001, Micron.

[18]  Sverre Myhra,et al.  Determination of the spring constants of probes for force microscopy/spectroscopy , 1996 .

[19]  Timothy Senden,et al.  Experimental Determination of Spring Constants in Atomic Force Microscopy , 1994 .

[20]  John Hedley,et al.  Accurate analytical measurements in the atomic force microscope: a microfabricated spring constant standard potentially traceable to the SI , 2003, Nanotechnology.

[21]  Calvin F. Quate,et al.  Microfabrication of cantilever styli for the atomic force microscope , 1990 .

[22]  Calvin F. Quate,et al.  Silicon nitride cantilevers with oxidation-sharpened silicon tips for atomic force microscopy , 2002 .

[23]  R. Nuzzo,et al.  Synthesis, Structure, and Properties of Model Organic Surfaces , 1992 .

[24]  Matthias Rief,et al.  Single molecule force spectroscopy by AFM indicates helical structure of poly(ethylene-glycol) in water , 1999 .

[25]  J. Bechhoefer,et al.  Erratum: ‘‘Calibration of atomic‐force microscope tips’’ [Rev. Sci. Instrum. 64, 1868 (1993)] , 1993 .

[26]  J. Sader,et al.  Calibration of rectangular atomic force microscope cantilevers , 1999 .

[27]  Butt,et al.  Measuring adhesion, attraction, and repulsion between surfaces in liquids with an atomic-force microscope. , 1992, Physical review. B, Condensed matter.

[28]  A. Limanskii Functionalization of amino-modified probes for atomic force microscopy , 2006 .

[29]  P. Hansma,et al.  An atomic-resolution atomic-force microscope implemented using an optical lever , 1989 .

[30]  J. Israelachvili Intermolecular and surface forces , 1985 .

[31]  Robert W. Dutton,et al.  Effects of capacitors, resistors, and residual charges on the static and dynamic performance of electrostatically actuated devices , 1999, Design, Test, Integration, and Packaging of MEMS/MOEMS.

[32]  T. A. Michalske,et al.  The interfacial-force microscope , 1992, Nature.

[33]  M. Rief,et al.  Mechanical stability of single DNA molecules. , 2000, Biophysical journal.

[34]  M. Rief,et al.  How strong is a covalent bond? , 1999, Science.

[35]  Gil U. Lee,et al.  Direct measurement of the forces between complementary strands of DNA. , 1994, Science.