Association between APE1 Asp148Glu polymorphism and the risk of urinary cancers: a meta-analysis of 18 case-control studies.

BACKGROUND Several observational studies suggested that APE1 Asp148Glu was significantly associated with urinary cancers; however, the results of published studies are inconsistent. MATERIALS AND METHODS The PubMed and EMBASE were searched for case-control studies regarding the association between Asp148Glu and the risk of urinary cancers with a time limit of September 12, 2015. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of the association between Asp148Glu and the risk of developing prostate cancer, kidney cancer, bladder cancer, as well as all urinary cancers combined. RESULTS A total of 18 case-control studies were included in the analysis. Our meta-analysis revealed that the inheritance of at least one APE1 148Glu among Asian men was associated with a 1.26-fold increase in the risk of developing urinary cancers. Meanwhile, APE1 Asp148Glu was significantly associated with the risk of prostate cancer. However, there were no significant relationships between the APE1 SNP (single nucleotide polymorphism) and all urinary cancers combined and bladder cancer and kidney cancer among the men of Caucasian/Asian/African descent or all racial/ethnic groups combined. When stratified by the quality score, no significant association was found in high-quality studies (score ≥7), but a significant increased risk of urinary cancers was observed in lower quality studies (score <7) (dominant model: OR=1.27, 95% CI=1.11-1.45). CONCLUSION Our meta-analysis suggests that APE1 Asp148Glu was not associated with the risk of urinary cancers but might increase the risk of urinary cancers among Asians. Stratification by cancer type identified a significant association of Asp148Glu with prostate cancer.

[1]  A. Tarang,et al.  The association between 1349T>G polymorphism of ApE1 gene and the risk of prostate cancer in northern Iran. , 2015, Cellular and molecular biology.

[2]  Wei-jia Gao,et al.  The association between the APE1 Asp148Glu polymorphism and prostate cancer susceptibility: a meta-analysis based on case–control studies , 2015, Molecular Genetics and Genomics.

[3]  Hong-yan Cheng,et al.  Association between survivin -31G>C polymorphism and cancer risk: meta-analysis of 29 studies , 2014, Journal of Cancer Research and Clinical Oncology.

[4]  T. Sellers,et al.  Gene variants in the angiogenesis pathway and prostate cancer. , 2012, Carcinogenesis.

[5]  R. Mandal,et al.  Base excision repair pathway genes polymorphism in prostate and bladder cancer risk in North Indian population , 2012, Mechanisms of Ageing and Development.

[6]  R. Mandal,et al.  Polymorphisms in base-excision & nucleotide-excision repair genes & prostate cancer risk in north Indian population , 2012, The Indian journal of medical research.

[7]  Pu Li,et al.  Genetic polymorphisms in APE1 are associated with renal cell carcinoma risk in a Chinese population , 2011, Molecular carcinogenesis.

[8]  Yajie Wang,et al.  APE1 Asp148Glu gene polymorphism and bladder cancer risk: a meta-analysis , 2011, Molecular Biology Reports.

[9]  Lucia A. Hindorff,et al.  Genetic architecture of cancer and other complex diseases: lessons learned and future directions. , 2011, Carcinogenesis.

[10]  H. Kuasne,et al.  Base excision repair genes XRCC1 and APEX1 and the risk for prostate cancer , 2011, Molecular Biology Reports.

[11]  F. Wiklund.  Prostate cancer genomics: can we distinguish between indolent and fatal disease using genetic markers? , 2010, Genome Medicine.

[12]  C. Qin,et al.  Genetic variants of XRCC1, APE1, and ADPRT genes and risk of bladder cancer. , 2010, DNA and cell biology.

[13]  Douglas F Easton,et al.  Genome-wide association studies in common cancers--what have we learnt? , 2010, Current opinion in genetics & development.

[14]  Weining Tang,et al.  Abstract 931: Innate immunity-related sequence variants (TOLLIP, TLR2) as predictors of prostate cancer risk among men of African descent , 2010 .

[15]  P. Vineis,et al.  ERCC1 haplotypes modify bladder cancer risk: a case-control study. , 2010, DNA repair.

[16]  Nicole A. Lavender,et al.  No association between variant DNA repair genes and prostate cancer risk among men of African descent , 2009, The Prostate.

[17]  Philippe Dessen,et al.  Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk. , 2009, Carcinogenesis.

[18]  T. Isbir,et al.  Bladder cancer and polymorphisms of DNA repair genes (XRCC1, XRCC3, XPD, XPG, APE1, hOGG1). , 2009, Anticancer research.

[19]  K. Bhakat,et al.  Transcriptional regulatory functions of mammalian AP-endonuclease (APE1/Ref-1), an essential multifunctional protein. , 2009, Antioxidants & redox signaling.

[20]  G. Tell,et al.  The many functions of APE1/Ref-1: not only a DNA repair enzyme. , 2009, Antioxidants & redox signaling.

[21]  R. D. Mittal,et al.  Influence of XPD and APE1 DNA repair gene polymorphism on bladder cancer susceptibility in north India. , 2009, Urology.

[22]  Paolo Vineis,et al.  DNA Repair Polymorphisms Modify Bladder Cancer Risk: A Multi-factor Analytic Strategy , 2007, Human Heredity.

[23]  N. Malats,et al.  Genetic variation in the base excision repair pathway and bladder cancer risk , 2007, Human Genetics.

[24]  Xifeng Wu,et al.  High-Order Interactions among Genetic Variants in DNA Base Excision Repair Pathway Genes and Smoking in Bladder Cancer Susceptibility , 2007, Cancer Epidemiology Biomarkers & Prevention.

[25]  Jack A. Taylor,et al.  APE1 genotype and risk of bladder cancer: Evidence for effect modification by smoking , 2006, International journal of cancer.

[26]  F. Clavel-Chapelon,et al.  DNA repair polymorphisms and cancer risk in non-smokers in a cohort study. , 2006, Carcinogenesis.

[27]  Margaret R Karagas,et al.  Concordance of multiple analytical approaches demonstrates a complex relationship between DNA repair gene SNPs, smoking and bladder cancer susceptibility. , 2006, Carcinogenesis.

[28]  R. Millikan,et al.  Bladder cancer predisposition: a multigenic approach to DNA-repair and cell-cycle-control genes. , 2006, American journal of human genetics.

[29]  Ammarin Thakkinstian,et al.  Systematic review and meta-analysis of the association between {beta}2-adrenoceptor polymorphisms and asthma: a HuGE review. , 2005, American journal of epidemiology.

[30]  M. Höglund,et al.  Constitutional short telomeres are strong genetic susceptibility markers for bladder cancer. , 2005, Carcinogenesis.

[31]  I. M. Jones,et al.  Many amino acid substitution variants identified in DNA repair genes during human population screenings are predicted to impact protein function. , 2004, Genomics.

[32]  Matthew B Schabath,et al.  An Evolutionary Perspective on Single-Nucleotide Polymorphism Screening in Molecular Cancer Epidemiology , 2004, Cancer Research.

[33]  E. Friedberg,et al.  The role of endogenous and exogenous DNA damage and mutagenesis. , 2004, Current opinion in genetics & development.

[34]  E. Parlanti,et al.  The base excision repair: mechanisms and its relevance for cancer susceptibility. , 2003, Biochimie.

[35]  W. Au,et al.  Functional characterization of polymorphisms in DNA repair genes using cytogenetic challenge assays. , 2003, Environmental health perspectives.

[36]  D. Altman,et al.  Measuring inconsistency in meta-analyses , 2003, BMJ : British Medical Journal.

[37]  J. Hirschhorn,et al.  A comprehensive review of genetic association studies , 2002, Genetics in Medicine.

[38]  H. Mohrenweiser,et al.  Amino acid substitution variants of APE1 and XRCC1 genes associated with ionizing radiation sensitivity. , 2001, Carcinogenesis.

[39]  M. Kelley,et al.  Going APE over ref-1. , 2000, Mutation research.

[40]  K. Fidelis,et al.  Functional characterization of Ape1 variants identified in the human population. , 2000, Nucleic acids research.

[41]  A. Tomkinson,et al.  Requirement for human AP endonuclease 1 for repair of 3'-blocking damage at DNA single-strand breaks induced by reactive oxygen species. , 2000, Carcinogenesis.

[42]  G. Smith,et al.  Bias in meta-analysis detected by a simple, graphical test , 1997, BMJ.

[43]  I. Hickson,et al.  Structure and function of apurinic/apyrimidinic endonucleases , 1995, BioEssays : news and reviews in molecular, cellular and developmental biology.

[44]  C. Robson,et al.  Structure of the human DNA repair gene HAP1 and its localisation to chromosome 14q 11.2-12. , 1992, Nucleic acids research.

[45]  K. Dickersin.  The existence of publication bias and risk factors for its occurrence. , 1990, JAMA.

[46]  N. Laird,et al.  Meta-analysis in clinical trials. , 1986, Controlled clinical trials.

[47]  W. Haenszel,et al.  Statistical aspects of the analysis of data from retrospective studies of disease. , 1959, Journal of the National Cancer Institute.

[48]  A. Jemal,et al.  Cancer statistics, 2015 , 2015, CA: a cancer journal for clinicians.

[49]  J. Chen,et al.  Association of the polymorphism of APE1 gene with the risk of prostate cancer in Chinese Han population. , 2013, Clinical laboratory.

[50]  T. Sellers,et al.  Single nucleotide polymorphisms in DNA repair genes and prostate cancer risk. , 2009, Methods in molecular biology.

[51]  T. Sellers,et al.  Association between polymorphisms in the DNA repair genes XRCC1 and APE1, and the risk of prostate cancer in white and black Americans. , 2006, The Journal of urology.

[52]  A. Jemal,et al.  Global cancer statistics , 2011, CA: a cancer journal for clinicians.

[53]  B. Glickman,et al.  Human DNA repair systems: An overview , 1999, Environmental and molecular mutagenesis.

[54]  A. Tobías.  Assessing the influence of a single study in the meta-anyalysis estimate , 1999 .

[55]  N. Dubrawsky.  Cancer statistics , 1989, CA: a cancer journal for clinicians.