Closing the mind's eye: deactivation of visual cortex related to auditory task difficulty

Blood oxygen-level-dependent signal decreases relative to baseline (deactivations) can occur with stimulation of an opposing sensory modality. Here, we show the importance of the difficulty of an auditory task on the deactivation of visual cortical areas. Participants performed an auditory temporal-order judgment task in conjunction with sparse-sampling functional MRI at both moderate and high levels of difficulty (adjusted for each individual's own threshold). With moderate difficulty, small deactivations were observed not only in parietal and cingulate cortex, but occipital cortex as well. When the same task was more difficult, deactivations increased significantly to include a greater extent of functionally defined visual cortex. Together, these results suggest that cross-modal deactivations occur in compensation for task difficulty, perhaps acting as an intrinsic filter for nonrelevant information.

[1]  C. Spence,et al.  The Handbook of Multisensory Processing , 2004 .

[2]  Geraint Rees,et al.  Sound alters activity in human V1 in association with illusory visual perception , 2006, NeuroImage.

[3]  R. Bowtell,et al.  “sparse” temporal sampling in auditory fMRI , 1999, Human brain mapping.

[4]  Y. Yen,et al.  Deactivation of Sensory-Specific Cortex by Cross-Modal Stimuli , 2002, Journal of Cognitive Neuroscience.

[5]  M. Raichle,et al.  Searching for a baseline: Functional imaging and the resting human brain , 2001, Nature Reviews Neuroscience.

[6]  S. Yantis,et al.  Control of Attention Shifts between Vision and Audition in Human Cortex , 2004, The Journal of Neuroscience.

[7]  R Kawashima,et al.  Positron-emission tomography studies of cross-modality inhibition in selective attentional tasks: closing the "mind's eye". , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[8]  E. DeYoe,et al.  A comparison of visual and auditory motion processing in human cerebral cortex. , 2000, Cerebral cortex.

[9]  Notger G. Müller,et al.  Competing Neural Responses for Auditory and Visual Decisions , 2007, PloS one.

[10]  Robert J. Zatorre,et al.  Neural substrates for dividing and focusing attention between simultaneous auditory and visual events , 2006, NeuroImage.

[11]  R. Knight,et al.  Contribution of Human Prefrontal Cortex to Delay Performance , 1998, Journal of Cognitive Neuroscience.

[12]  M. Wallace,et al.  Unifying multisensory signals across time and space , 2004, Experimental Brain Research.

[13]  John J. Foxe,et al.  Multisensory auditory-visual interactions during early sensory processing in humans: a high-density electrical mapping study. , 2002, Brain research. Cognitive brain research.

[14]  Henry Kennedy,et al.  Long-distance feedback projections to area V1: Implications for multisensory integration, spatial awareness, and visual consciousness , 2004, Cognitive, affective & behavioral neuroscience.

[15]  Ramon Casanova,et al.  Biological parametric mapping: A statistical toolbox for multimodality brain image analysis , 2007, NeuroImage.

[16]  Joseph A Maldjian,et al.  Separating neural processes using mixed event-related and epoch-based fMRI paradigms , 2003, Journal of Neuroscience Methods.

[17]  R. Zatorre,et al.  Attention to simultaneous unrelated auditory and visual events: behavioral and neural correlates. , 2005, Cerebral cortex.

[18]  J. Binder,et al.  A Parametric Manipulation of Factors Affecting Task-induced Deactivation in Functional Neuroimaging , 2003, Journal of Cognitive Neuroscience.

[19]  Brian N. Pasley,et al.  Analysis of oxygen metabolism implies a neural origin for the negative BOLD response in human visual cortex , 2007, NeuroImage.

[20]  Paul J. Laurienti,et al.  An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets , 2003, NeuroImage.

[21]  M. Corbetta,et al.  Top-down modulation of early sensory cortex. , 1997 .

[22]  Thomas E. Nichols,et al.  Controlling the familywise error rate in functional neuroimaging: a comparative review , 2003, Statistical methods in medical research.

[23]  Leslie G. Ungerleider,et al.  The functional organization of human extrastriate cortex: a PET-rCBF study of selective attention to faces and locations , 1994, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[24]  E. Miller,et al.  An integrative theory of prefrontal cortex function. , 2001, Annual review of neuroscience.

[25]  P. Barone,et al.  Heteromodal connections supporting multisensory integration at low levels of cortical processing in the monkey , 2005, The European journal of neuroscience.