Rapid T1 mapping of mouse myocardium with saturation recovery look‐locker method

Dynamic contrast‐enhanced MRI using gadolinium or manganese provides unique characterization of myocardium and its pathology. In this study, an electrocardiography (ECG) triggered saturation recovery Look‐Locker method was developed and validated for fast cardiac T1 mapping in small animal models. By sampling the initial portion of the longitudinal magnetization recovery curve, high temporal resolution (∼3 min) can be achieved at a high spatial resolution (195 × 390 μm2) in mouse heart without the aid of parallel imaging or echo‐planar imaging. Validation studies were performed both in vitro on a phantom and in vivo on C57BL/6 mice (n = 6). Our results showed a strong agreement between T1 measured by saturation recovery Look‐Locker and by the standard saturation recovery method in vitro or inversion recovery Look‐Locker in vivo. The utility of saturation recovery Look‐Locker in dynamic contrast‐enhanced MRI studies was demonstrated in manganese‐enhanced MRI experiments in mice. Our results suggest that saturation recovery Look‐Locker can provide rapid and accurate cardiac T1 mapping for studies using small animal models. Magn Reson Med, 2010. © 2010 Wiley‐Liss, Inc.

[1]  Autumn M. Schumacher,et al.  Assessing manganese efflux using SEA0400 and cardiac T1‐mapping manganese‐enhanced MRI in a murine model , 2009, NMR in biomedicine.

[2]  D. Altman,et al.  STATISTICAL METHODS FOR ASSESSING AGREEMENT BETWEEN TWO METHODS OF CLINICAL MEASUREMENT , 1986, The Lancet.

[3]  Xin Yu,et al.  Transmural myocardial strain in mouse: Quantification of high‐resolution MR tagging using harmonic phase (HARP) analysis , 2009, Magnetic resonance in medicine.

[4]  Ralf Deichmann,et al.  Fast high‐resolution T1 mapping of the human brain , 2005, Magnetic resonance in medicine.

[5]  Kieran Clarke,et al.  Fast, high‐resolution in vivo cine magnetic resonance imaging in normal and failing mouse hearts on a vertical 11.7 T system , 2003, Journal of magnetic resonance imaging : JMRI.

[6]  T W Redpath,et al.  Accuracy of T1 measurement in dynamic contrast‐enhanced breast MRI using two‐ and three‐dimensional variable flip angle fast low‐angle shot , 1999, Journal of magnetic resonance imaging : JMRI.

[7]  A. Koretsky,et al.  Manganese‐enhanced MRI of mouse heart during changes in inotropy † , 2001, Magnetic resonance in medicine.

[8]  Udo Sechtem,et al.  MR imaging of myocardial perfusion and viability. , 2003, Magnetic resonance imaging clinics of North America.

[9]  R. Slutsky,et al.  Tissue distribution and magnetic resonance spin lattice relaxation effects of gadolinium-DTPA. , 1985, Radiology.

[10]  C. Higgins,et al.  MR contrast media for myocardial viability, microvascular integrity and perfusion. , 2000, European journal of radiology.

[11]  Robert R Edelman,et al.  Contrast-enhanced MR imaging of the heart: overview of the literature. , 2004, Radiology.

[12]  R. Deichmann,et al.  Fast T1 mapping on a whole‐body scanner , 1999, Magnetic resonance in medicine.

[13]  J. Pauly,et al.  Saturated double‐angle method for rapid B1+ mapping , 2006, Magnetic resonance in medicine.

[14]  Yu-Chung N. Cheng,et al.  Magnetic Resonance Imaging: Physical Principles and Sequence Design , 1999 .

[15]  I. Young,et al.  Variations in slice shape and absorption as artifacts in the determination of tissue parameters in NMR imaging , 1985, Magnetic resonance in medicine.

[16]  Kai-Hsiang Chuang,et al.  Improved neuronal tract tracing using manganese enhanced magnetic resonance imaging with fast T1 mapping , 2006, Magnetic resonance in medicine.

[17]  B. Nordell,et al.  Phantom and in vivo study of the Look-Locher T1 mapping method. , 1999, Magnetic resonance imaging.

[18]  Klaas Nicolay,et al.  MRI contrast agents: current status and future perspectives. , 2007, Anti-cancer agents in medicinal chemistry.

[19]  P M Jakob,et al.  Rapid quantitative lung 1H T1 mapping , 2001, Journal of magnetic resonance imaging : JMRI.

[20]  A. Koretsky,et al.  Manganese enhanced magnetic resonance imaging of normal and ischemic canine heart , 2005, Magnetic resonance in medicine.

[21]  F. Kelcz,et al.  Accurate and rapid quantitative dynamic contrast‐enhanced breast MR imaging using spoiled gradient‐recalled echoes and bookend T1 measurements , 1999, Magnetic resonance in medicine.

[22]  M. Horsfield,et al.  Dynamic T1 measurement using snapshot-FLASH MRI. , 1997, Journal of magnetic resonance.

[23]  Maolin Qiu,et al.  T1 measurements incorporating flip angle calibration and correction in vivo. , 2006, Journal of magnetic resonance.

[24]  M. Zaitsev,et al.  Fast T1 mapping with volume coverage , 2001, Magnetic resonance in medicine.

[25]  A. Crawley,et al.  A comparison of one‐shot and recovery methods in T1 imaging , 1988, Magnetic resonance in medicine.

[26]  Kai-Hsiang Chuang,et al.  Monitoring dynamic alterations in calcium homeostasis by T 1‐weighted and T 1‐mapping cardiac manganese‐enhanced MRI in a murine myocardial infarction model , 2008, NMR in biomedicine.

[27]  G J Parker,et al.  Accurate multislice gradient echo T1 measurement in the presence of non‐ideal RF pulse shape and RF field nonuniformity , 2001, Magnetic resonance in medicine.

[28]  Alan Jackson,et al.  Comparative study of methods for determining vascular permeability and blood volume in human gliomas , 2004, Journal of magnetic resonance imaging : JMRI.

[29]  S. H. Koenig,et al.  Theory of proton relaxation in solutions of magnetic nanoparticles, including the superparamagnetic size range. , 1996, Academic radiology.

[30]  S. Plein,et al.  Myocardial T1 mapping: Application to patients with acute and chronic myocardial infarction , 2007, Magnetic resonance in medicine.

[31]  Olav Haraldseth,et al.  An apparent unidirectional influx constant for manganese as a measure of myocardial calcium channel activity , 2006, Journal of magnetic resonance imaging : JMRI.

[32]  David M Higgins,et al.  Modified Look‐Locker inversion recovery (MOLLI) for high‐resolution T1 mapping of the heart , 2004, Magnetic resonance in medicine.

[33]  R Deichmann,et al.  Quantification of T1 values by SNAPSHOT-FLASH NMR imaging , 1992 .

[34]  A. Beckett,et al.  AKUFO AND IBARAPA. , 1965, Lancet.