Serum lipoproteins and coronary heart disease in a population study of Hawaii Japanese men.

To ascertain the frequency of defined hyperlipoproteinemia and to investigate the relation between lipoprotein fractions and coronary heart disease, we measured serum lipoprotein cholesterol levels in a population-based sample of Hawaii Japanese men 50 to 72 years old. Type II hyperlipoproteinemia was present in 3 per cent of 1859 men, and Type IV in 26 per cent. Relative risks for coronary heart disease, based on 264 prevalence cases, were found to be 1.8, 1.8 and 0.46, between the upper and lower quartiles of total, beta, and alpha cholesterol, respectively. We found no significant relation between triglyceride and coronary heart disease. The inverse relation of alpha cholesterol of prevalence of coronary heart disease was independent of beta cholesterol, obesity, and other factors. The data suggest the need for further evaluation of the protective effect of the alpha lipoprotein fraction on the development of coronary heart disease.

[1]  D. Brunner,et al.  Serum cholesterol, electrophoretic lipid pattern, diet and coronary artery disease: a study in coronary patients and in healthy men of different origin and occupations in Israel. , 1958, Annals of internal medicine.

[2]  D. E. Lamphiear,et al.  Biochemical precursors of atherosclerosis. Studies in apparently healthy men in a general population, Tecumseh, Mich. , 1974, Archives of internal medicine.

[3]  D. Fredrickson,et al.  Tangier disease (familial high density lipoprotein deficiency). Clinical and genetic features in two adults. , 1965, The American journal of medicine.

[4]  H. Kato,et al.  Epidemiologic studies of coronary heart disease and stroke in Japanese men living in Japan, Hawaii and California. , 1973, American journal of epidemiology.

[5]  R. Levy,et al.  A comparison of heritable abnormal lipoprotein patterns as defined by two different techniques. , 1968, The Journal of clinical investigation.

[6]  L. Carlson,et al.  Quantitative and qualitative serum lipoprotein analysis. Part 2. Studies in male survivors of myocardial infarction. , 1975, Atherosclerosis.

[7]  C. Jenkins,et al.  Recurring and fatal myocardial infarction in the Western Collaborative Group Study. , 1967, The American journal of cardiology.

[8]  J. Medalie,et al.  Five-year myocardial infarction incidence. II. Association of single variables to age and birthplace. , 1973, Journal of chronic diseases.

[9]  G. Mills,et al.  Influence of myocardial infarction on plasma-lipoprotein concentration. , 1959, Lancet.

[10]  K. Støa Determination of thiocyanate in blood serum. , 1953, Scandinavian journal of clinical and laboratory investigation.

[11]  R. Worth,et al.  Ascertainment of men of Japanese ancestry in Hawaii through World War II Selective Service registration. , 1970, Journal of chronic diseases.

[12]  W. Kannel,et al.  Differences in coronary heart disease in Framingham, Honolulu and Puerto Rico. , 1974, Journal of chronic diseases.

[13]  R. Lees,et al.  Fat transport in lipoproteins--an integrated approach to mechanisms and disorders. , 2009, The New England journal of medicine.

[14]  G. S. Boyd,et al.  SERUM LIPOPROTEIN PATTERNS IN CORONARY SCLEROSIS AND ASSOCIATED CONDITIONS , 1955, British heart journal.

[15]  H. Eder,et al.  Protein-lipid relationships in human plasma. II. In atherosclerosis and related conditions. , 1951, The American journal of medicine.

[16]  Strother H. Walker,et al.  Estimation of the probability of an event as a function of several independent variables. , 1967, Biometrika.

[17]  L. Carlson Serum lipids in men with myocardial infarction. , 2009, Acta medica Scandinavica.

[18]  J. Glomset,et al.  The plasma lecithins:cholesterol acyltransferase reaction. , 1968, Journal of lipid research.

[19]  A. Keys,et al.  Serum Cholesterol and Relative Body Weight of Coronary Patients in Different Populations , 1960, Circulation.

[20]  G. Miller,et al.  PLASMA-HIGH-DENSITY-LIPOPROTEIN CONCENTRATION AND DEVELOPMENT OF ISCHÆMIC HEART-DISEASE , 1975, The Lancet.

[21]  W. Kannel,et al.  Serum cholesterol, lipoproteins, and the risk of coronary heart disease. The Framingham study. , 2020, Annals of internal medicine.

[22]  G. Reaven,et al.  Prevalence of Plasma Lipoprotein Abnormalities in a Free‐Living Population of the Central Valley, California , 1972, Circulation.

[23]  W. Haenszel,et al.  Statistical aspects of the analysis of data from retrospective studies of disease. , 1959, Journal of the National Cancer Institute.

[24]  W. Jencks,et al.  A study of serum lipoproteins in normal and atherosclerotic patients by paper electrophoretic techniques. , 1956, The Journal of clinical investigation.