Anticonvulsant Action of Diazepam: Increase of Cortical Postsynaptic Inhibition

The action of intravenously administered diazepam (Valium®) on postsynaptic inhibition was studied in cat motor cortex. The efficacy of postsynaptic inhibition of pyramidal tract cells was measured as the ability to suppress action potential generation. Diazepam increased the suppression of action potentials by inhibition.

[1]  B. Gähwiler.  Diazepam and chlordiazepoxide: powerful GABA antagonists in explants of rat cerebellum , 1976, Brain Research.

[2]  W. Raabe,et al.  Diphenylhydantoin increases cortical postsynaptic inhibition , 1976, Brain Research.

[3]  D. Felix,et al.  Antagonistic effects of GABA and benzodiazepines on vestibular and cerebellar neurones , 1976, Nature.

[4]  J. Eccles,et al.  Prolongation of hippocampal inhibitory postsynaptic potentials by barbiturates , 1975, Nature.

[5]  L. Pieri,et al.  Possible involvement of GABA in the central actions of benzodiazepines. , 1975, Psychopharmacology bulletin.

[6]  A. Guidotti,et al.  New concepts on the mechanism of action of benzodiazepines. , 1975, Life sciences.

[7]  K. Krnjević,et al.  Chemical Nature of Synaptic Transmission in Vertebrates , 1974 .

[8]  T. Browne,et al.  Benzodiazepines in the Treatment of Epilepsy A Review , 1973, Epilepsia.

[9]  J. Korein,et al.  Diagnostic value of diazepam in electroencephalography. , 1972, Archives of neurology.

[10]  W. Spencer,et al.  Penicillin-induced interictal discharges from the cat hippocampus. I. Characteristics and topographical features. , 1969, Journal of neurophysiology.

[11]  D. Prince,et al.  Control mechanisms in cortical epileptogenic foci. "Surround" inhibition. , 1967, Archives of neurology.

[12]  P. Cooper.  The benzodiazepines. , 1979, Midwife, health visitor & community nurse.

[13]  A. Suria,et al.  Evidence for GABA involvement in the action of diazepam on presynaptic nerve terminals in bullfrog sympathetic ganglia. , 1975, Advances in biochemical psychopharmacology.

[14]  L. Pieri,et al.  Possible involvement of GABA in the central actions of benzodiazepines. , 1975, Advances in biochemical psychopharmacology.

[15]  D. Greenblatt,et al.  Benzodiazepines in Clinical Practice , 1974 .

[16]  R. Schmidt,et al.  [Effect of diazepam on presynaptic inhibition and other spinal reflexes]. , 1967, Naunyn-Schmiedebergs Archiv fur experimentelle Pathologie und Pharmakologie.