Differentiation and cell division in the mammalian thymus.

[1]  K. Hirokawa,et al.  Intrathymic T cell differentiation in radiation bone marrow chimeras and its role in T cell emigration to the spleen. An immunohistochemical study. , 1985, Journal of immunology.

[2]  B. Fowlkes,et al.  Intrathymic differentiation: Thymocyte heterogeneity and the characterization of early t-cell precursors , 1985, Survey of immunologic research.

[3]  Mark M. Davis,et al.  Expression of genes of the T-cell antigen receptor complex in precursor thymocytes , 1985, Nature.

[4]  J. Yagüe,et al.  Rearrangement of T-cell receptor beta-chain genes during T-cell development. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[5]  T. Malek,et al.  Proliferation of thymic stem cells with and without receptors for interleukin 2. Implications for intrathymic antigen recognition , 1985, The Journal of experimental medicine.

[6]  R. Schulte,et al.  Evidence that the Pgp-1 glycoprotein is expressed on thymus-homing progenitor cells of the thymus. , 1985, Cellular immunology.

[7]  W. Ewijk,et al.  Repopulation of the mouse thymus after sublethal fission neutron irradiation. I. Sequential appearance of thymocyte subpopulations. , 1985, Journal of immunology.

[8]  D. Raulet.  Expression and function of interleukin-2 receptors on immature thymocytes , 1985, Nature.

[9]  J. Lowenthal,et al.  Expression of interleukin-2 receptors as a differentiation marker on intrathymic stem cells , 1985, Nature.

[10]  S. Tonegawa,et al.  Developmental regulation of T-cell receptor gene expression , 1985, Nature.

[11]  A. Weiss,et al.  Activation of a human T cell line: a two-stimulus requirement in the pretranslational events involved in the coordinate expression of interleukin 2 and gamma-interferon genes. , 1985, Journal of immunology.

[12]  G. Mills,et al.  Increase in cytosolic free calcium concentration is an intracellular messenger for the production of interleukin 2 but not for expression of the interleukin 2 receptor. , 1985, Journal of immunology.

[13]  E. Reinherz.  A molecular basis for thymic selection: regulation of T11 induced thymocyte expansion by the T3-Ti antigen/MHC receptor pathway. , 1985, Immunology today.

[14]  M. Ho,et al.  Ontogeny of proliferative and cytotoxic responses to interleukin 2 and concanavalin A in murine fetal thymus. , 1985, Journal of immunology.

[15]  S. Grinstein,et al.  Characterization of the activation of Na+/H+ exchange in lymphocytes by phorbol esters: change in cytoplasmic pH dependence of the antiport. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[16]  J. Imboden,et al.  Transmembrane signalling by the T cell antigen receptor. Perturbation of the T3-antigen receptor complex generates inositol phosphates and releases calcium ions from intracellular stores , 1985, The Journal of experimental medicine.

[17]  A. Krensky,et al.  Phytohaemagglutinin activation of T cells through the sheep red blood cell receptor , 1985, Nature.

[18]  H. Snodgrass,et al.  Ontogeny of the T-cell antigen receptor within the thymus , 1985, Nature.

[19]  John P. Moore,et al.  A common sequence of calcium and pH signals in the mitogenic stimulation of eukaryotic cells , 1985, Nature.

[20]  T. Hirano,et al.  Effect of recombinant IL 2 and gamma-IFN on proliferation and differentiation of human B cells. , 1985, Journal of immunology.

[21]  S. Tonegawa,et al.  Structure, organization, and somatic rearrangement of T cell gamma genes , 1985, Cell.

[22]  D. Cantrell,et al.  Interleukin 2 regulates its own receptors. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[23]  P. Golstein,et al.  Early steps of lymphocyte activation bypassed by synergy between calcium ionophores and phorbol ester , 1985, Nature.

[24]  E. Reinherz,et al.  The human T-cell receptor , 1985, Journal of Clinical Immunology.

[25]  E. Reinherz,et al.  Activation of human thymocytes via the 50KD T11 sheep erythrocyte binding protein induces the expression of interleukin 2 receptors on both T3+ and T3- populations. , 1985, Journal of immunology.

[26]  B. Fowlkes,et al.  Cell Surface Antigen Expression on Thymocytes: Development and Phenotypic Differentiation of Intrathymic Subsets , 1984, Immunological reviews.

[27]  R. E. Cunningham,et al.  Regulation of interleukin 2 receptor expression: effects of phorbol diester, phospholipase C, and reexposure to lectin or antigen. , 1984, Journal of immunology.

[28]  K. Shortman,et al.  T Cell Development in the Adult Murine Thymus: Changes in the Expression of the Surface Antigens Ly2, L3T4 and B2A2 during Development from Early Precursor Cells to Emigrants , 1984, Immunological reviews.

[29]  Michael J. Berridge,et al.  Inositol trisphosphate, a novel second messenger in cellular signal transduction , 1984, Nature.

[30]  T. Waldmann,et al.  Expression of interleukin 2 receptors on activated human B cells , 1984, The Journal of experimental medicine.

[31]  A. Weiss,et al.  Requirement for the coexpression of T3 and the T cell antigen receptor on a malignant human T cell line , 1984, The Journal of experimental medicine.

[32]  E. Rothenberg,et al.  High-level secretion of interleukin 2 by a subset of proliferating thymic lymphoblasts. , 1984, Journal of immunology.

[33]  W. Leiserson,et al.  Differentiation of thymocytes in fetal organ culture: analysis of phenotypic changes accompanying the appearance of cytolytic and interleukin 2-producing cells. , 1984, Journal of immunology.

[34]  P. Marrack,et al.  The major histocompatibility complex-restricted antigen receptor on T cells: Distribution on thymus and peripheral T cells , 1984, Cell.

[35]  B. Kyewski,et al.  Intrathymic lymphopoiesis: stromal cell-associated proliferation of T cells is independent of lymphocyte genotype. , 1984, Journal of immunology.

[36]  R. Scearce,et al.  The human thymic microenvironment: cortical thymic epithelium is an antigenically distinct region of the thymic microenvironment. , 1984, Journal of immunology.

[37]  I. Weissman,et al.  A homing receptor-bearing cortical thymocyte subset: Implications for thymus cell migration and the nature of cortisone-resistant thymocytes , 1984, Cell.

[38]  W. Ewijk.  Immunohistology of lymphoid and non‐lymphoid cells in the thymus in relation to T lymphocyte differentiation , 1984 .

[39]  D. Sheiness,et al.  Expression of a proto-oncogene (proto-myb) in hemopoietic tissues of mice , 1984, Molecular and cellular biology.

[40]  I. Weissman,et al.  Bone marrow cells give rise to distinct cell clones within the thymus , 1984, Nature.

[41]  I. Weissman,et al.  The immunocompetence of murine stromal cell-associated thymocytes. , 1984, Journal of immunology.

[42]  S. Efrat,et al.  Control of biologically active interleukin 2 messenger RNA formation in induced human lymphocytes. , 1984, Proceedings of the National Academy of Sciences of the United States of America.

[43]  B. Haynes,et al.  Phenotypic characterization and ontogeny of mesodermal-derived and endocrine epithelial components of the human thymic microenvironment , 1984, The Journal of experimental medicine.

[44]  E. Reinherz,et al.  An alternative pathway of T-cell activation: A functional role for the 50 kd T11 sheep erythrocyte receptor protein , 1984, Cell.

[45]  G. Crabtree,et al.  T-cell growth factor: complete nucleotide sequence and organization of the gene in normal and malignant cells. , 1984, Proceedings of the National Academy of Sciences of the United States of America.

[46]  E. Reinherz,et al.  Triggering of the T3-Ti antigen-receptor complex results in clonal T-cell proliferation through an interleukin 2-dependent autocrine pathway. , 1984, Proceedings of the National Academy of Sciences of the United States of America.

[47]  M. Bogart,et al.  Mechanism of T-cell lymphomagenesis: transformation of growth-factor-dependent T-lymphoblastoma cells to growth-factor-independent T-lymphoma cells. , 1984, Proceedings of the National Academy of Sciences of the United States of America.

[48]  M. Moal,et al.  B-cell ontogeny , 1984 .

[49]  P. Marrack,et al.  The major histocompatibility complex-restricted antigen receptor on T cells. , 1984, Annual review of immunology.

[50]  J. Ortaldo,et al.  Heterogeneity of natural killer cells. , 1984, Annual review of immunology.

[51]  W. F. Chen,et al.  The functional capabilities of cells leaving the thymus. , 1984, Journal of immunology.

[52]  T. Diamantstein,et al.  Detection and localization by the monoclonal antiinterleukin 2 receptor antibody AMT‐13 of IL 2 receptor‐bearing cells in the developing thymus of the mouse embryo and in the thymus of cortisone‐treated mice , 1984, European journal of immunology.

[53]  M. Melis,et al.  Monoclonal antibodies to stromal cell types of the mouse thymus , 1984, European journal of immunology.

[54]  R. Ceredig,et al.  Immunohistochemical localization of host and donor-derived cells in the regenerating thymus of radiation bone marrow chimeras. , 1984, Thymus.

[55]  John P. Moore,et al.  Mitogens increase phosphorylation of phosphoinositides in thymocytes , 1984, Nature.

[56]  T. Taniguchi,et al.  Structure of the human interleukin 2 gene. , 1983, Proceedings of the National Academy of Sciences of the United States of America.

[57]  P. Marrack,et al.  Evidence implicating L3T4 in class II MHC antigen reactivity; monoclonal antibody GK1.5 (anti-L3T4a) blocks class II MHC antigen-specific proliferation, release of lymphokines, and binding by cloned murine helper T lymphocyte lines. , 1983, Journal of immunology.

[58]  H. Macdonald,et al.  Precursors of T cell growth factor producing cells in the thymus: ontogeny, frequency, and quantitative recovery in a subpopulation of phenotypically mature thymocytes defined by monoclonal antibody GK-1.5 , 1983, The Journal of experimental medicine.

[59]  E. Gelfand,et al.  Purine and pyrimidine metabolism in human T lymphocytes. Regulation of deoxyribonucleotide metabolism. , 1983, The Journal of biological chemistry.

[60]  P. Marrack,et al.  THE MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTED ANTIGEN RECEPTOR ON T CELLS , 2003 .

[61]  K. Shortman,et al.  Thymocyte subpopulations: an experimental review, including flow cytometric cross-correlations between the major murine thymocyte markers. , 1983, Thymus.

[62]  I. Weissman,et al.  Characteristics of thymus-homing bone marrow cells. , 1983, Journal of immunology.

[63]  E. Reinherz,et al.  Comparison of T3-associated 49- and 43-kilodalton cell surface molecules on individual human T-cell clones: evidence for peptide variability in T-cell receptor structures. , 1983, Proceedings of the National Academy of Sciences of the United States of America.

[64]  I. Weissman,et al.  A cell-surface molecule involved in organ-specific homing of lymphocytes , 1983, Nature.

[65]  E. Podack,et al.  Cytolysis by H-2-specific T killer cells. Assembly of tubular complexes on target membranes , 1983, The Journal of experimental medicine.

[66]  J. Borst,et al.  The T3 complex on human T lymphocytes involves four structurally distinct glycoproteins. , 1983, The Journal of biological chemistry.

[67]  D. Triglia,et al.  Clonal proliferation unlinked to terminal deoxynucleotidyl transferase synthesis in thymocytes of young mice. , 1983, Journal of immunology.

[68]  W. F. Chen,et al.  The Ly phenotype of functional medullary thymocytes. , 1983, Thymus.

[69]  E. Reinherz,et al.  Clonotypic structures involved in antigen-specific human T cell function. Relationship to the T3 molecular complex , 1983, The Journal of experimental medicine.

[70]  J. Borst,et al.  The T3 complex on human thymus‐derived lymphocytes contains two different subunits of 20 kDa , 1983, European journal of immunology.

[71]  G. Janossy,et al.  Distribution of terminal deoxynucleotidyl transferase and purine degradative and synthetic enzymes in subpopulations of human thymocytes. , 1982, Journal of immunology.

[72]  H. Macdonald,et al.  Cell cycle regulation of cloned cytolytic T cells by T cell growth factor: analysis by flow microfluorometry. , 1982, Journal of immunology.

[73]  J. Bishop,et al.  Transcripts from the Cellular Homologs of Retroviral Oncogenes: Distribution Among Chicken Tissues , 1982, Molecular and cellular biology.

[74]  B. Kyewski,et al.  Lymphoepithelial interactions in the mouse thymus: phenotypic and kinetic studies on thymic nurse cells. , 1982, Journal of immunology.

[75]  H. Macdonald,et al.  Phenotypic and functional properties of murine thymocytes. II. Quantitation of host- and donor-derived cytolytic T lymphocyte precursors in regenerating radiation bone marrow chimeras. , 1982, Journal of immunology.

[76]  H. Macdonald,et al.  Phenotypic and functional properties of murine thymocytes. I. Precursors of cytolytic T lymphocytes and interleukin 2-producing cells are all contained within a subpopulation of “mature” thymocytes as analyzed by monoclonal antibodies and flow microfluorometry , 1982, The Journal of experimental medicine.

[77]  H. Macdonald,et al.  Development of cytolytic T lymphocyte precursors in organ-cultured mouse embryonic thymus rudiments , 1982, The Journal of experimental medicine.

[78]  R. Tsien,et al.  T-cell mitogens cause early changes in cytoplasmic free Ca2+ and membrane potential in lymphocytes , 1982, Nature.

[79]  E. Rothenberg.  A specific biosynthetic marker for immature thymic lymphoblasts. Active synthesis of thymus-leukemia antigen restricted to proliferating cells , 1982, The Journal of experimental medicine.

[80]  S. Swain.  Significance of Lyt phenotypes: Lyt2 antibodies block activities of T cells that recognize class 1 major histocompatibility complex antigens regardless of their function. , 1981, Proceedings of the National Academy of Sciences of the United States of America.

[81]  B. Stadler,et al.  Relationship of cell cycle to recovery of IL 2 activity from human mononuclear cells, human and mouse T cell lines. , 1981, Journal of immunology.

[82]  P. Doherty,et al.  Virus-immune and alloreactive response characteristics of thymocytes and spleen cells from young mice. , 1981, Journal of immunology.

[83]  I. Weissman,et al.  An in vivo assay for thymus-homing bone marrow cells , 1981, Nature.

[84]  W. Boersma,et al.  Post‐Irradiation Thymocyte Regeneration After Bone Marrow Transplantation I. Regeneration and Quantification of Thymocyte Progenitor Cells In the Bone Marrow , 1981, Cell and tissue kinetics.

[85]  J. Dangl,et al.  T cell ontogeny. Organ location of maturing populations as defined by surface antigen markers is similar in neonates and adults , 1981, The Journal of experimental medicine.

[86]  M. Loken,et al.  Lyt-2-/Lyt 3- variants of a cloned cytolytic T cell line lack an antigen receptor functional in cytolysis , 1981, The Journal of experimental medicine.

[87]  E. Jenkinson,et al.  Embryology of the lymphoid system. , 1981, Progress in allergy.

[88]  V. Rotter,et al.  Abelson murine leukemia virus-induced tumors elicit antibodies against a host cell protein, P50 , 1980, Journal of virology.

[89]  D. Longo,et al.  T-cell specificity for H–2 and Ir gene phenotype correlates with the phenotype of thymic antigen-presenting cells , 1980, Nature.

[90]  I. Weissman,et al.  Thymus cell migration: Quantitative aspects of cellular traffic from the thymus to the periphery in mice , 1980, European journal of immunology.

[91]  H. Wekerle,et al.  Thymic nurse cells—Ia-bearing epithelium involved in T-lymphocyte differentiation? , 1980, Nature.

[92]  R. Ceredig.  Frequency of alloreactive cytotoxic T cell precursors in the mouse thymus and spleen during ontogeny. , 1979, Transplantation.

[93]  K. Shortman,et al.  The differentiation of T lymphocytes. V. Evidence for intrathymic death of most thymocytes. , 1979, Thymus.

[94]  C. Stiles,et al.  Control of the Balb/c‐3T3 cell cycle by nutrients and serum factors: Analysis using platelet‐derived growth factor and platelet‐poor plasma , 1979, Journal of cellular physiology.

[95]  R. Kerbel,et al.  Adult and pre-adult thymectomy of mice: contrasting effects on immune responsiveness, and on numbers of mitogen-responsive and Thy-1+ lymphocytes. , 1979, Immunology.

[96]  B. Kindred.  Nude mice in immunology. , 1979, Progress in allergy.

[97]  E. Cooper,et al.  Ontogeny of cell-mediated cytotoxicity: induction of CTL in early postnatal thymocytes. , 1979, Journal of immunology.

[98]  E. Butcher,et al.  Lyt markers on thymus cell migrants , 1978, Nature.

[99]  T. Mandel,et al.  The differentiation of murine thymocytes in vivo and in vitro. , 1978, Immunology.

[100]  P. Vassalli,et al.  In vitro maturation of immature thymocytes into immunocompetent T cells in the absence of direct thymic influence , 1978, The Journal of experimental medicine.

[101]  R. Basch,et al.  Hematopoietic thymocyte precursors: III. A population of thymocytes with the capacity to return (“home”) to the thymus , 1977 .

[102]  R. Basch,et al.  Hematopoietic thymocyte precursors: II. Properties of the precursors , 1977, The Journal of experimental medicine.

[103]  E. Cronkite,et al.  FATE OF THYMOCYTES: STUDIES WITH 125I‐IODODEOXYURIDINE AND 3H‐THYMIDINE IN MICE , 1977, Cell and tissue kinetics.

[104]  M. H. Claësson,et al.  CYTODYNAMICS IN THE THYMUS OF YOUNG ADULT MICE: , 1976, Cell and tissue kinetics.

[105]  R. Basch,et al.  Hematopoietic thymocyte precursors. I. Assay and kinetics of the appearance of progeny , 1976, The Journal of experimental medicine.

[106]  S. Chwalinski,et al.  ON THE SPARSE SEEDING OF BONE MARROW AND THYMUS IN RADIATION CHIMAERAS , 1975, Transplantation.

[107]  R. Basch,et al.  Thymic regeneration after lethal irradiation evidence for an intra-thymic radioresistant T cell precursor. , 1975, Journal of immunology.

[108]  K. Shortman,et al.  The differentiation of T lymphocytes. I. Proliferation kinetics and interrelationships of subpopulations of mouse thymus cells. , 1974, Cellular immunology.

[109]  D. Baltimore.  Is terminal deoxynucleotidyl transferase a somatic mutagen in lymphocytes? , 1974, Nature.

[110]  L. Feinendegen,et al.  DIFFERENCES IN REUTILIZATION OF THYMIDINE IN HEMOPOIETIC AND LYMPHOPOIETIC TISSUES OF THE NORMAL MOUSE , 1973, Cell and tissue kinetics.

[111]  S. L. Clark.  The Intrathymic Environment , 1973 .

[112]  R. Aspinall,et al.  Renewal and fate in the mammalian thymus: Mechanisms and inferences of thymocytokinetics , 1972, European journal of immunology.

[113]  M. Papiernik.  Correlation of lymphocyte transformation and morphology in the human fetal thymus. , 1970, Blood.

[114]  I. Weissman.  THYMUS CELL MIGRATION , 1967, The Journal of experimental medicine.

[115]  D. Metcalf.  The Structure of the Thymus , 1966 .

[116]  C. P. Leblond,et al.  Elaboration of a model for the formation of lymphocytes in the thymic cortex of young adult rats. , 1965, Blood.