Photoprotective Effect of Fermented and Aged Mountain-Cultivated Ginseng Sprout (Panax ginseng) on Ultraviolet Radiation-Induced Skin Aging in a Hairless Mouse Model

Interest in foods that promote inner beauty increases with increases in exposure to ultraviolet (UV) rays and with improvements in quality of life. This study was performed to evaluate the efficacy of fermented and aged mountain-cultivated ginseng sprouts (FAMCGSs), which have higher anti-inflammatory and antioxidant effects compared to mountain-cultivated ginseng sprouts (MCGSs), as an inner beauty enhancing food. The effect of orally administered FAMCGSs on UV type B (UVB) radiation-induced skin aging was investigated in a hairless mouse model through analyzing skin parameters including epidermal thickness, transepidermal water loss (TEWL), roughness, moisture, elasticity, and collagen contents. The mice exposed to UVB had markedly greater epidermal thickness, TEWL, and skin roughness than those of the normal control (NC) group. In addition, the levels of collagen, skin moisture, and dermal elasticity were lower in the UVB radiation group than the NC group. These UVB-induced skin aging parameters were significantly lower in the groups administered FAMCGSs than in the groups not administered FAMCGSs (p < 0.05). These results show that FAMCGSs exhibit a photoprotective effect in mice exposed to UVB and suggest that FAMCGSs can be used as a food that promotes inner beauty and protects skin from UVB-induced photoaging.

[1]  H. Lee,et al.  Changes in Chemical Compositions and Antioxidant Activities from Fresh to Fermented Red Mountain-Cultivated Ginseng , 2022, Molecules.

[2]  H. Lee,et al.  Comparative assessment of compositional constituents and antioxidant effects in ginseng sprouts (Panax ginseng) through aging and fermentation processes , 2022, LWT.

[3]  V. Velebný,et al.  Hyaluronan: A key player or just a bystander in skin photoaging? , 2021, Experimental dermatology.

[4]  H. Lee,et al.  Changes in nutritional compositions of processed mountain-cultivated ginseng sprouts (Panax ginseng) and screening for their antioxidant and anti-inflammatory properties , 2021 .

[5]  Liwei Sun,et al.  Protective effect of oligosaccharides isolated from Panax ginseng C. A. Meyer against UVB-induced skin barrier damage in BALB/c hairless mice and human keratinocytes. , 2021, Journal of ethnopharmacology.

[6]  Liwei Sun,et al.  Panax ginseng C. A. Meyer Phenolic Acid Extract Alleviates Ultraviolet B-Irradiation-Induced Photoaging in a Hairless Mouse Skin Photodamage Model , 2021, Evidence-based complementary and alternative medicine : eCAM.

[7]  Sang-Han Lee,et al.  Prunus mume Seed Exhibits Inhibitory Effect on Skin Senescence via SIRT1 and MMP-1 Regulation , 2021, Oxidative medicine and cellular longevity.

[8]  D. Chung,et al.  Effect of the Oral Administration of Common Evening Primrose Sprout (Oenothera biennis L.) Extract on Skin Function Improvement in UVB-irradiated Hairless Mice , 2021, Pharmaceuticals.

[9]  C. C. White,et al.  Environmental effects of stratospheric ozone depletion, UV radiation, and interactions with climate change: UNEP Environmental Effects Assessment Panel, Update 2020 , 2021, Photochemical & Photobiological Sciences.

[10]  M. Rhee,et al.  Anti-Melanogenic Effects of Korean Red Ginseng Oil in an Ultraviolet B-Induced Hairless Mouse Model , 2020, Molecules.

[11]  H. Suh,et al.  Enhancement of isoflavone aglycone, amino acid, and CLA contents in fermented soybean yogurts using different strains: Screening of antioxidant and digestive enzyme inhibition properties. , 2020, Food chemistry.

[12]  Anshul Sharma,et al.  Ginsenoside Compound K: Insights into Recent Studies on Pharmacokinetics and Health-Promoting Activities , 2020, Biomolecules.

[13]  K. Lee,et al.  Oral Intake of Hydrangea serrata (Thunb.) Ser. Leaves Extract Improves Wrinkles, Hydration, Elasticity, Texture, and Roughness in Human Skin: A Randomized, Double-Blind, Placebo-Controlled Study , 2020, Nutrients.

[14]  Abidullah Khan,et al.  Neferine prevents ultraviolet radiation-induced skin photoaging , 2020, Experimental and therapeutic medicine.

[15]  Jisoo Park,et al.  Relationship Between Ginsenoside Rg3 and Metabolic Syndrome , 2020, Frontiers in Pharmacology.

[16]  Wenyu Lu,et al.  Promotion of compound K production in Saccharomyces cerevisiae by glycerol , 2020, Microbial Cell Factories.

[17]  Somin Lee,et al.  Wheat Extract Oil (WEO) Attenuates UVB-Induced Photoaging via Collagen Synthesis in Human Keratinocytes and Hairless Mice. , 2020, Nutrients.

[18]  Sullim Lee,et al.  Compound K improves skin barrier function by increasing SPINK5 expression , 2019, Journal of ginseng research.

[19]  Qianqian Zhou,et al.  Ginsenoside compound K ameliorates imiquimod-induced psoriasis-like dermatitis through inhibiting REG3A/RegIIIγ expression in keratinocytes. , 2019, Biochemical and biophysical research communications.

[20]  M. Choi,et al.  Effects of gut microbiota on the pharmacokinetics of protopanaxadiol ginsenosides Rd, Rg3, F2, and compound K in healthy volunteers treated orally with red ginseng , 2019, Journal of ginseng research.

[21]  Sang-Han Lee,et al.  Attenuation of UVB-Induced Photo-Aging by Polyphenolic-Rich Spatholobus Suberectus Stem Extract Via Modulation of MAPK/AP-1/MMPs Signaling in Human Keratinocytes , 2019, Nutrients.

[22]  I. Song,et al.  Tolerability and pharmacokinetics of ginsenosides Rb1, Rb2, Rc, Rd, and compound K after single or multiple administration of red ginseng extract in human beings , 2018, Journal of ginseng research.

[23]  Barbara A. Gilchrest.  Photoaging. , 2013, The Journal of investigative dermatology.

[24]  L. Eckhart,et al.  The skin barrier: Epidermis vs environment , 2018, Experimental dermatology.

[25]  J. Cho,et al.  The skin protective effects of compound K, a metabolite of ginsenoside Rb1 from Panax ginseng , 2017, Journal of ginseng research.

[26]  R. Lin,et al.  Remarkable impact of steam temperature on ginsenosides transformation from fresh ginseng to red ginseng , 2017, Journal of ginseng research.

[27]  J. Cho,et al.  Photoaging protective effects of BIOGF1K, a compound-K-rich fraction prepared from Panax ginseng , 2017, Journal of ginseng research.

[28]  T. Makino,et al.  Ginsenosides, ingredients of the root of Panax ginseng, are not substrates but inhibitors of sodium-glucose transporter 1 , 2016, Journal of Natural Medicines.

[29]  H. Suh,et al.  Photoprotective effects of topical ginseng leaf extract using Ultraflo L against UVB-induced skin damage in hairless mice , 2016, Journal of ginseng research.

[30]  M. Lee,et al.  Enhanced Absorption Study of Ginsenoside Compound K (20-O-β-(D-Glucopyranosyl)-20(S)-protopanaxadiol) after Oral Administration of Fermented Red Ginseng Extract (HYFRG™) in Healthy Korean Volunteers and Rats , 2016, Evidence-based complementary and alternative medicine : eCAM.

[31]  Xianlong Cheng,et al.  Identification of mountain-cultivated ginseng and cultivated ginseng using UPLC/oa-TOF MSE with a multivariate statistical sample-profiling strategy , 2015, Journal of ginseng research.

[32]  Sang Myung Lee,et al.  Characterization of Korean Red Ginseng (Panax ginseng Meyer): History, preparation method, and chemical composition , 2015, Journal of ginseng research.

[33]  N. Kang,et al.  20-O-β-D-glucopyranosyl-20(S)-protopanaxadiol, a metabolite of ginsenoside Rb1, enhances the production of hyaluronic acid through the activation of ERK and Akt mediated by Src tyrosin kinase in human keratinocytes. , 2015, International journal of molecular medicine.

[34]  J. Lyga,et al.  Brain-Skin Connection: Stress, Inflammation and Skin Aging , 2014, Inflammation & allergy drug targets.

[35]  S. Kim,et al.  Enzyme-processed Korean Red Ginseng extracts protects against skin damage induced by UVB irradiation in hairless mice , 2013, Journal of ginseng research.

[36]  B. Poljšak,et al.  Skin Photoaging and the Role of Antioxidants in Its Prevention , 2013, ISRN dermatology.

[37]  B. Poljšak,et al.  Skin and antioxidants , 2013, Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology.

[38]  Young Ju Lee,et al.  UV radiation-induced skin aging in hairless mice is effectively prevented by oral intake of sea buckthorn (Hippophae rhamnoides L.) fruit blend for 6 weeks through MMP suppression and increase of SOD activity. , 2012, International journal of molecular medicine.

[39]  G. Karakiulakis,et al.  Hyaluronic acid: A key molecule in skin aging , 2012, Dermato-endocrinology.

[40]  Wei Xia,et al.  Matrix-degrading metalloproteinases in photoaging. , 2009, The journal of investigative dermatology. Symposium proceedings.

[41]  H. Park,et al.  Effects of red ginseng extract on UVB irradiation-induced skin aging in hairless mice. , 2009, Journal of ethnopharmacology.

[42]  Y. Kimura,et al.  Effects of ginseng saponins isolated from red ginseng on ultraviolet B-induced skin aging in hairless mice. , 2009, European journal of pharmacology.

[43]  Hong Xu,et al.  Differentiation of the root of Cultivated Ginseng, Mountain Cultivated Ginseng and Mountain Wild Ginseng using FT-IR and two-dimensional correlation IR spectroscopy , 2008 .

[44]  V. Hearing,et al.  Human skin pigmentation: melanocytes modulate skin color in response to stress , 2007, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[45]  L. Baumann,et al.  Skin ageing and its treatment , 2007, The Journal of pathology.

[46]  T. Makino,et al.  Ginsenosides, ingredients of the root of Panax ginseng, are not substrates but inhibitors of sodium-glucose transporter 1 , 2016, Journal of Natural Medicines.

[47]  Guo-ping Yang,et al.  A review of biotransformation and pharmacology of ginsenoside compound K. , 2015, Fitoterapia.