Intranuclear inclusions in conventional clear cell Renal Cell Carcinoma (RCC): A case report and review of the literature

Intranuclear inclusions are important diagnostic features in many benign and malignant neoplasms. It has also been identifi ed in major epithelial subtypes of renal cell carcinomas (RCCs), particularly in the chromophobe RCC. However, the fi nding in ccRCC has not been well studied. The fi nding of intranuclear inclusions may cause diagnostic diffi culty, particularly in metastatic lesions. Herein, we reported a case of ccRCC with prominent intranuclear inclusions. The tumor also metastasized to local lymph nodes. Furthermore, in contrast to previous publications, we also found that intranuclear inclusions were immunoreactive with anti-PAX8 (paired box8) antibody. The potential diagnostic and clinical implications of intranuclear inclusions in ccRCC need to be addressed. Case Report Intranuclear inclusions in conventional clear cell Renal Cell Carcinoma (RCC): A case report and review of the literature Aryn McClain1, Lynne Sakowski2, Michele Conti2, Hui Zhang2 and Qing Kay Li2* 1Department of Anatomical Pathology, University of Maryland Baltimore, Baltimore, MD, 21201, USA 2The Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21224, USA Received: 26 September, 2018 Accepted: 23 October, 2018 Published: 24 October, 2018 *Corresponding author: Qing Kay Li, MD PhD, Associate Professor, Department of Pathology, The Johns Hopkins Bayview Medical Center, 4940 Eastern Ave. Building AA, Room 154B, Baltimore, MD 21224, USA, Tel: (410) 550-0671; E-mail: