Glucolipotoxicity initiates pancreatic β-cell death through TNFR5/CD40-mediated STAT1 and NF-κB activation
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G. Hitman | G. Ball | J. Kieswich | M. Bugliani | P. Marchetti | M. D. Turner | B. Nedjai | M. Yaqoob | B. Ogunkolade | T. Jones | Marta Bagnati | P. Caton | Katie Hanna | C. Marshall | C. Tucci
[1] H. Woodrow,et al. : A Review of the , 2018 .
[2] P. Marchetti. Islet inflammation in type 2 diabetes , 2016, Diabetologia.
[3] D. Mears,et al. Glucose-Dependent Insulin Secretion in Pancreatic β-Cell Islets from Male Rats Requires Ca2+ Release via ROS-Stimulated Ryanodine Receptors , 2015, PloS one.
[4] A. Pedersen,et al. Anti-CD40-mediated cancer immunotherapy: an update of recent and ongoing clinical trials , 2014, Immunopharmacology and immunotoxicology.
[5] U. Boggi,et al. Are we overestimating the loss of beta cells in type 2 diabetes? , 2014, Diabetologia.
[6] D. Kowalski,et al. A Phase 1, Randomized Ascending Single‐Dose Study of Antagonist Anti‐Human CD40 ASKP1240 in Healthy Subjects , 2013, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.
[7] D. van der Kooy,et al. The adult mammalian pancreas contains separate precursors of pancreatic and neural crest developmental origins. , 2013, Stem cells and development.
[8] U. Boggi,et al. Microarray analysis of isolated human islet transcriptome in type 2 diabetes and the role of the ubiquitin–proteasome system in pancreatic beta cell dysfunction , 2013, Molecular and Cellular Endocrinology.
[9] T. Mandrup-Poulsen,et al. Transcriptional and translational regulation of cytokine signaling in inflammatory β-cell dysfunction and apoptosis. , 2012, Archives of biochemistry and biophysics.
[10] E. A. Ismail,et al. Soluble CD40L in children and adolescents with type 1 diabetes: relation to microvascular complications and glycemic control , 2012, Pediatric diabetes.
[11] S. Jagannath,et al. A phase 1 study of lucatumumab, a fully human anti‐CD40 antagonist monoclonal antibody administered intravenously to patients with relapsed or refractory multiple myeloma , 2012, British journal of haematology.
[12] M. Inoue,et al. Insulin resistance and cancer: epidemiological evidence. , 2012, Endocrine-related cancer.
[13] J. Byrd,et al. Phase I study of the anti-CD40 humanized monoclonal antibody lucatumumab (HCD122) in relapsed chronic lymphocytic leukemia , 2012, Leukemia & lymphoma.
[14] M. Ezzati,et al. National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2·7 million participants , 2011, The Lancet.
[15] T. Ørntoft,et al. STAT1 Is a Master Regulator of Pancreatic β-Cell Apoptosis and Islet Inflammation* , 2010, The Journal of Biological Chemistry.
[16] M. Inoue,et al. Insulin resistance and cancer: Epidemiological evidence , 2010, Cancer science.
[17] D. Leroith,et al. Type 2 diabetes and cancer: what is the connection? , 2010, The Mount Sinai journal of medicine, New York.
[18] L. Zitvogel,et al. Pyroptosis – a cell death modality of its kind? , 2010, European journal of immunology.
[19] J. Börgel,et al. Influence of glycaemic control on platelet bound CD40–CD40L system, P‐selectin and soluble CD40 ligand in Type 2 diabetes , 2009, Diabetic medicine : a journal of the British Diabetic Association.
[20] G. Hitman,et al. Proinflammatory action of the antiinflammatory drug infliximab in tumor necrosis factor receptor-associated periodic syndrome. , 2009, Arthritis and rheumatism.
[21] Lincoln Stein,et al. Reactome knowledgebase of human biological pathways and processes , 2008, Nucleic Acids Res..
[22] C. Ricordi,et al. CD40 activation in human pancreatic islets and ductal cells , 2008, Diabetologia.
[23] H. Ellingsgaard,et al. Increased Number of Islet-Associated Macrophages in Type 2 Diabetes , 2007, Diabetes.
[24] M. Andersen,et al. Reactive Oxygen Species as a Signal in Glucose-Stimulated Insulin Secretion , 2007, Diabetes.
[25] G. Hitman,et al. Effect of glucolipotoxicity and rosiglitazone upon insulin secretion. , 2007, Biochemical and biophysical research communications.
[26] T. Wekerle,et al. New approaches to prevent transplant rejection: Co-stimulation blockers anti-CD40L and CTLA4Ig , 2006 .
[27] C. Murphy. Using whole-genome transcriptional analyses to identify molecular mechanisms of aging , 2006 .
[28] V. Mohan,et al. Soluble P-selectin and CD40L levels in subjects with prediabetes, diabetes mellitus, and metabolic syndrome--the Chennai Urban Rural Epidemiology Study. , 2006, Metabolism: clinical and experimental.
[29] N. Munshi,et al. Human anti-CD40 antagonist antibody triggers significant antitumor activity against human multiple myeloma. , 2005, Cancer research.
[30] D. Klein,et al. A functional CD40 receptor is expressed in pancreatic beta cells , 2005, Diabetologia.
[31] Christopher J. Rhodes,et al. Type 2 Diabetes-a Matter of ß-Cell Life and Death? , 2005, Science.
[32] S. Wild,et al. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. , 2004, Diabetes care.
[33] D. Boumpas,et al. Lessons learned from anti-CD40L treatment in systemic lupus erythematosus patients , 2004, Lupus.
[34] G. Illei,et al. A short course of BG9588 (anti-CD40 ligand antibody) improves serologic activity and decreases hematuria in patients with proliferative lupus glomerulonephritis. , 2003, Arthritis and rheumatism.
[35] D. Ron,et al. Endoplasmic reticulum stress and the development of diabetes: a review. , 2002, Diabetes.
[36] H. Joller-jemelka,et al. Glucose-induced β cell production of IL-1β contributes to glucotoxicity in human pancreatic islets. , 2002, The Journal of clinical investigation.
[37] Christophe Benoist,et al. β-Cell death during progression to diabetes , 2001, Nature.
[38] C. Wollheim,et al. Mitochondrial glutamate acts as a messenger in glucose-induced insulin exocytosis , 1999, Nature.
[39] P. Maechler,et al. Free radical modulation of insulin release in INS-1 cells exposed to alloxan. , 1999, Biochemical pharmacology.
[40] P. Behn,et al. A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome) , 1998, Nature Genetics.
[41] S. Lenzen,et al. Relation Between Antioxidant Enzyme Gene Expression and Antioxidative Defense Status of Insulin-Producing Cells , 1997, Diabetes.
[42] G. Hitman,et al. Differential cytokine secretion resulting from p65 and c-Rel NF-kappaB subunit signaling in peripheral blood mononuclear cells of TNFR-associated periodic fever syndrome patients , 2011 .
[43] G. Hitman,et al. Differential cytokine secretion results from p65 and c-Rel NF-κB subunit signaling in peripheral blood mononuclear cells of TNF receptor-associated periodic syndrome patients. , 2011, Cellular immunology.
[44] H. Ellingsgaard,et al. Islet Inflammation Impairs the Pancreatic β-Cell in Type 2 Diabetes , 2009 .
[45] G. Hitman,et al. Proinflammatory action of the antiinflammatory drug infliximab in TNF-receptor associated periodic syndrome , 2009 .
[46] G. Hitman,et al. Abnormal tumor necrosis factor receptor I cell surface expression and NF-kappaB activation in tumor necrosis factor receptor-associated periodic syndrome. , 2008, Arthritis and rheumatism.
[47] C. Rhodes. Type 2 diabetes-a matter of beta-cell life and death? , 2005, Science.
[48] C Benoist,et al. beta-Cell death during progression to diabetes. , 2001, Nature.