Topographic EEG changes with normal aging and SDAT.

EEG topography was compared in patients with senile dementia of the Alzheimer's type (SDAT), aged normal controls, and young normal controls to assess regional differences. The square root of absolute power was determined for each frequency using a Fast Fourier Transform (FFT). The normal elderly group showed a reduction in all 4 frequency bands, delta, theta, alpha and beta, at each of 32 leads when compared to the young controls. Z-transformation of the data revealed differences in topography. Older normals showed significantly greater mid-parietal and left mid-temporal delta than the younger controls. A similar pattern was seen for theta activity. Elderly controls showed relatively less occipital alpha and greater mid-parietal alpha. Beta activity demonstrated these same significant topographic differences. The elderly/SDAT comparison was significant for delta only. SDAT patients were characterized by a marked delta asymmetry in temporal regions which was not seen in the elderly normals.

[1]  M. Matousek,et al.  EEG frequency analysis related to age in normal adults. , 1967, Electroencephalography and clinical neurophysiology.

[2]  H. Soininen,et al.  EEG findings in senile dementia and normal aging , 1982, Acta neurologica Scandinavica.

[3]  W. Obrist,et al.  Electroencephalographic frequency analysis of aged psychiatric patients. , 1958, Electroencephalography and clinical neurophysiology.

[4]  M H Gail,et al.  A generalization of the one-sided two-sample Kolmogorov-Smirnov statistic for evaluating diagnostic tests. , 1976, Biometrics.

[5]  S Giaquinto,et al.  The EEG in the normal elderly: a contribution to the interpretation of aging and dementia. , 1986, Electroencephalography and clinical neurophysiology.

[6]  R Coppola,et al.  Topographic cortical mapping of EEG sleep stages during daytime naps in normal subjects. , 1982, Sleep.

[7]  J. R. Hughes,et al.  The EEG in patients at different ages without organic cerebral disease. , 1977, Electroencephalography and clinical neurophysiology.

[8]  F H Duffy,et al.  Brain electrical activity in patients with presenile and senile dementia of the Alzheimer type , 1984, Annals of neurology.

[9]  B. Reisberg,et al.  Abnormal Temporal Lobe Response in Alzheimer's Disease during Cognitive Processing as Measured by 11C-2-Deoxy-D-Glucose and PET , 1987, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[10]  J. Haxby,et al.  Positron emission tomography in Alzheimer's disease , 1986, Neurology.

[11]  J C Shaw,et al.  The EEG and Differential Diagnosis in Psychogeriatrics , 1979, British Journal of Psychiatry.

[12]  R. Loewenson,et al.  The electroencephalogram of elderly subjects revisited. , 1983, Electroencephalography and clinical neurophysiology.

[13]  H. Soininen,et al.  Quantitative analysis of occipital EEG in different stages of Alzheimer's disease. , 1985, Electroencephalography and clinical neurophysiology.

[14]  Robert P. Friedland,et al.  Alzheimer's disease: Anterior-posterior and lateral hemispheric alterations in cortical glucose utilization , 1985, Neuroscience Letters.

[15]  R Coppola,et al.  A new system for gray-level surface distribution maps of electrical activity. , 1982, Electroencephalography and clinical neurophysiology.

[16]  W. Dixon,et al.  BMDP statistical software , 1983 .

[17]  D. Ingvar,et al.  EEG and cognitive impairment in presenile dementia , 1979, Acta neurologica Scandinavica.

[18]  M. Storandt,et al.  A longitudinal EEG study of mild senile dementia of Alzheimer type: changes at 1 year and at 2.5 years. , 1985, Electroencephalography and clinical neurophysiology.

[19]  C. C. Wood,et al.  Scalp distributions of event-related potentials: an ambiguity associated with analysis of variance models. , 1985, Electroencephalography and clinical neurophysiology.

[20]  B Stigsby,et al.  Regional EEG analysis and regional cerebral blood flow in Alzheimer's and Pick's diseases. , 1981, Electroencephalography and clinical neurophysiology.