Human tau expression reduces adult neurogenesis in a mouse model of tauopathy

[1]  Gloria Lee,et al.  Tau in MAPK Activation , 2013, Front. Neurol..

[2]  J. Arthur,et al.  Mitogen‐ and stress‐activated kinases regulate progenitor cell proliferation and neuron development in the adult dentate gyrus , 2012, Journal of neurochemistry.

[3]  D. Storm,et al.  Inducible and Targeted Deletion of the ERK5 MAP Kinase in Adult Neurogenic Regions Impairs Adult Neurogenesis in the Olfactory Bulb and Several Forms of Olfactory Behavior , 2012, PloS one.

[4]  S. Tonegawa,et al.  Young Dentate Granule Cells Mediate Pattern Separation, whereas Old Granule Cells Facilitate Pattern Completion , 2012, Cell.

[5]  P. Frankland,et al.  Posttraining Ablation of Adult-Generated Neurons Degrades Previously Acquired Memories , 2011, The Journal of Neuroscience.

[6]  Meaghan Morris,et al.  The Many Faces of Tau , 2011, Neuron.

[7]  Zacharias Kohl,et al.  Neurodegenerative disease and adult neurogenesis , 2011, The European journal of neuroscience.

[8]  T. Goldberg,et al.  MAPT isoforms: differential transcriptional profiles related to 3R and 4R splice variants. , 2011, Journal of Alzheimer's disease : JAD.

[9]  R. Ransohoff,et al.  Regulation of Tau Pathology by the Microglial Fractalkine Receptor , 2010, Neuron.

[10]  F. Calon,et al.  Widespread deficits in adult neurogenesis precede plaque and tangle formation in the 3xTg mouse model of Alzheimer’s disease , 2010, The European journal of neuroscience.

[11]  S. Pimplikar,et al.  APP Intracellular Domain Impairs Adult Neurogenesis in Transgenic Mice by Inducing Neuroinflammation , 2010, PloS one.

[12]  O. Lazarov,et al.  Neurogenesis and Alzheimer's disease: At the crossroads , 2010, Experimental Neurology.

[13]  F. Gage,et al.  New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory? , 2010, Nature Reviews Neuroscience.

[14]  N. Decarolis,et al.  Hippocampal neurogenesis as a target for the treatment of mental illness: A critical evaluation , 2010, Neuropharmacology.

[15]  Gloria Lee,et al.  Tau Potentiates Nerve Growth Factor-induced Mitogen-activated Protein Kinase Signaling and Neurite Initiation without a Requirement for Microtubule Binding* , 2010, The Journal of Biological Chemistry.

[16]  Gloria Lee,et al.  Microtubule‐associated protein tau in human prostate cancer cells: Isoforms, phosphorylation, and interactions , 2009, Journal of cellular biochemistry.

[17]  C. Greer,et al.  Adult neurogenesis and the olfactory system , 2009, Progress in Neurobiology.

[18]  P. Davies,et al.  Age-Dependent Impairment of Cognitive and Synaptic Function in the htau Mouse Model of Tau Pathology , 2009, The Journal of Neuroscience.

[19]  A. Verkhratsky,et al.  Impaired Adult Neurogenesis in the Dentate Gyrus of a Triple Transgenic Mouse Model of Alzheimer's Disease , 2008, PloS one.

[20]  L. Hou,et al.  Stem cells and neurodegenerative diseases , 2008, Science in China Series C: Life Sciences.

[21]  P. Lucassen,et al.  Changes in adult neurogenesis in neurodegenerative diseases: cause or consequence? , 2008, Genes, brain, and behavior.

[22]  Hideki Mori,et al.  Observational examination of aggregation and migration during early phase of neurosphere culture of mouse neural stem cells. , 2007, Journal of bioscience and bioengineering.

[23]  David V Schaffer,et al.  PI3K/Akt and CREB regulate adult neural hippocampal progenitor proliferation and differentiation , 2007, Developmental neurobiology.

[24]  G. Ramakers,et al.  Tau‐4R suppresses proliferation and promotes neuronal differentiation in the hippocampus of tau knockin/ knockout mice , 2007, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[25]  Simon Lovestone,et al.  p53 is upregulated in Alzheimer's disease and induces tau phosphorylation in HEK293a cells , 2007, Neuroscience Letters.

[26]  M. Rasenick,et al.  Tau associates with actin in differentiating PC12 cells , 2006, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[27]  D. Geschwind,et al.  PBK/TOPK, a Proliferating Neural Progenitor-Specific Mitogen-Activated Protein Kinase Kinase , 2005, The Journal of Neuroscience.

[28]  L. Pusztai,et al.  Microtubule Associated Protein (MAP)-Tau: A Novel Mediator of Paclitaxel Sensitivity In Vitro and In Vivo , 2005, Cell cycle.

[29]  P. Hof,et al.  Cell-Cycle Reentry and Cell Death in Transgenic Mice Expressing Nonmutant Human Tau Isoforms , 2005, The Journal of Neuroscience.

[30]  D. Ingram,et al.  Impact of age and caloric restriction on neurogenesis in the dentate gyrus of C57BL/6 mice , 2004, Neurobiology of Aging.

[31]  P. Davies,et al.  Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms , 2003, Journal of neurochemistry.

[32]  S. Barger,et al.  Interleukin-1 Mediates Pathological Effects of Microglia on Tau Phosphorylation and on Synaptophysin Synthesis in Cortical Neurons through a p38-MAPK Pathway , 2003, The Journal of Neuroscience.

[33]  Patrick R. Hof,et al.  Tau protein isoforms, phosphorylation and role in neurodegenerative disorders 1 1 These authors contributed equally to this work. , 2000, Brain Research Reviews.

[34]  F. Gage,et al.  Neurogenesis in the adult human hippocampus , 1998, Nature Medicine.

[35]  Gerd Kempermann,et al.  Experience-Induced Neurogenesis in the Senescent Dentate Gyrus , 1998, The Journal of Neuroscience.

[36]  U. Wagner,et al.  Cellular phosphorylation of tau by GSK-3 beta influences tau binding to microtubules and microtubule organisation. , 1996, Journal of cell science.

[37]  Brian J Cummings,et al.  Early phosphorylation of tau in Alzheimer's disease occurs at Ser-202 and is preferentially located within neurites. , 1994, Neuroreport.

[38]  Khadija Iqbal,et al.  Role of abnormally phosphorylated tau in the breakdown of microtubules in Alzheimer disease. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[39]  W. Klein,et al.  Microtubule-Associated Protein Tau Is Hyperphosphorylated during Mitosis in the Human Neuroblastoma Cell Line SH-SY5Y , 1994, Experimental Neurology.

[40]  J. Altman,et al.  Are New Neurons Formed in the Brains of Adult Mammals? , 1962, Science.

[41]  I. Mook‐Jung,et al.  Impaired hippocampal neurogenesis and its enhancement with ghrelin in 5XFAD mice. , 2014, Journal of Alzheimer's disease : JAD.

[42]  J. Ávila,et al.  Tau isoform with three microtubule binding domains is a marker of new axons generated from the subgranular zone in the hippocampal dentate gyrus: implications for Alzheimer's disease. , 2012, Journal of Alzheimer's disease : JAD.

[43]  L. Petrucelli,et al.  Molecular Neurodegeneration BioMed Central , 2009 .