Relation of bronchial responsiveness to body mass index in the ECRHS

Background: There is substantial evidence for an association between symptoms of asthma and overweight or obesity. However, a study that reported no association between bronchial responsiveness (BHR) and body mass index (BMI) suggested that the relation of symptoms to obesity was due to increased diagnosis of asthma. The relation of BHR to BMI was therefore investigated in a large multicentre study. Methods: Data were obtained for 11 277 participants in stage II of the European Community Respiratory Health Survey (ECRHS). BHR to methacholine was analysed in relation to BMI adjusted for a number of factors known to be associated with BHR, including baseline lung function and allergen sensitisation, and combined across 34 centres using random effects meta-analysis. Results: BHR increased with increasing BMI in men (ECRHS slope changed by –0.027 for each unit increase in BMI, 95% confidence interval –0.044 to –0.010, p=0.002), but the relation in women was weak (–0.014, 95% CI –0.033 to 0.005, p=0.14). There was no evidence for an interaction of sex with BMI (p=0.41). Conclusions: BHR is related to BMI in the ECRHS. This suggests that the association is not due to greater diagnosis or perception of symptoms in obese people compared with those of normal weight. The data do not support the finding by some studies of a relation between asthma and obesity in women but not in men.

[1]  D. Jarvis,et al.  The European Community Respiratory Health Survey II , 1994, European Respiratory Journal.

[2]  D. Jarvis,et al.  Association of body mass index with respiratory symptoms and atopy: results from the European Community Respiratory Health Survey , 2002, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[3]  S. Chinn,et al.  Can the increase in body mass index explain the rising trend in asthma in children? , 2001, Thorax.

[4]  D. Dockery,et al.  Relation of body mass index to asthma and atopy in children: the National Health and Nutrition Examination Study III , 2001, Thorax.

[5]  F Neukirch,et al.  The European Community Respiratory Health Survey: what are the main results so far? European Community Respiratory Health Survey II. , 2001, The European respiratory journal.

[6]  K. Tantisira,et al.  Complex interactions in complex traits: obesity and asthma. , 2001, Thorax.

[7]  S. Y. Young,et al.  Body mass index and asthma in the military population of the northwestern United States. , 2001, Archives of internal medicine.

[8]  J. Castro‐Rodriguez,et al.  Increased incidence of asthmalike symptoms in girls who become overweight or obese during the school years. , 2001, American journal of respiratory and critical care medicine.

[9]  E. von Mutius,et al.  Is obesity a risk factor for childhood asthma? , 2001, Allergy.

[10]  S. Chinn,et al.  Association between obesity and asthma in 4-11 year old children in the UK. , 2001, Thorax.

[11]  C. Salome,et al.  Obesity is a risk for asthma and wheeze but not airway hyperresponsiveness , 2001, Thorax.

[12]  T. Poussa,et al.  Immediate and long term effects of weight reduction in obese people with asthma: randomised controlled study , 2000, BMJ : British Medical Journal.

[13]  R. Irwin,et al.  The association of asthma and obesity: is it real or a matter of definition, Presbyterian minister's salaries, and earlobe creases? , 1999, Archives of internal medicine.

[14]  W. Willett,et al.  Prospective study of body mass index, weight change, and risk of adult-onset asthma in women. , 1999, Archives of internal medicine.

[15]  D. Jarvis,et al.  Sensitization to individual allergens and bronchial responsiveness in the ECRHS. European Community Respiratory Health Survey. , 1999, The European respiratory journal.

[16]  D. Krewski,et al.  Increased effects of smoking and obesity on asthma among female Canadians: the National Population Health Survey, 1994-1995. , 1999, American journal of epidemiology.

[17]  J. Sterne,et al.  Birth weight, body mass index and asthma in young adults , 1999, Thorax.

[18]  L. Epstein,et al.  The relationship between asthma and obesity in urban minority children and adolescents. , 1998, Archives of pediatrics & adolescent medicine.

[19]  D. Jarvis,et al.  Individual allergens as risk factors for bronchial responsiveness in young adults , 1998, Thorax.

[20]  Josep Roca,et al.  References values for forced spirometry , 1998 .

[21]  E. Luder,et al.  Association of being overweight with greater asthma symptoms in inner city black and Hispanic children. , 1998, The Journal of pediatrics.

[22]  D. Jarvis,et al.  Variation in bronchial responsiveness in the European Community Respiratory Health Survey (ECRHS). , 1997, The European respiratory journal.

[23]  D. Jarvis,et al.  Variation in nebulizer aerosol output and weight output from the Mefar dosimeter: implications for multicentre studies. , 1997, The European respiratory journal.

[24]  D. Jarvis,et al.  The European Community Respiratory Health Survey. , 1994, The European respiratory journal.

[25]  R. Kronmal.  Spurious Correlation and the Fallacy of the Ratio Standard Revisited , 1993 .

[26]  J E Cotes,et al.  Lung volumes and forced ventilatory flows , 1993, European Respiratory Journal.

[27]  C. Mascie-taylor,et al.  The relationship of childhood asthma and wheezy bronchitis with height, weight and body mass index. , 1987, Human biology.

[28]  N. Laird,et al.  Meta-analysis in clinical trials. , 1986, Controlled clinical trials.

[29]  P. Deurenberg,et al.  Associations of moderate and severe overweight with self-reported illness and medical care in Dutch adults. , 1986, American journal of public health.

[30]  R. Hauspie,et al.  A mixed longitudinal study of the growth in height and weight in asthmatic children. , 1976, Human biology.