Context sensitivity in individual-based modeling

The function of many bio-molecules and biological entities is dependent on their context. We can define context as anything influencing the molecule but which is not the molecule itself. For example, 'moonlighting' proteins [1] use various molecular mechanisms to switch between functions, such as differential localisation, complex formation and substrate formation; these can all be classified as context-dependent mechanisms. Cell function is also highly dependent on external signals and local environment e.g. [2]. Context sensitivity implies the following: