Pulmonary drug delivery of fine aerosol particles from supercritical fluids

ABSTRACT Better methods for delivery of pharmacologic agents directly to and via the lung are needed. We found that a solution of α-tocopherol (vitamin E) dissolved in supercritical carbon dioxide ...

[1]  R. Barkley,et al.  Supercritical fluid transport-chemical deposition of films , 1992 .

[2]  R. Barkley,et al.  Deposition of palladium films by a novel supercritical fluid transport-chemical deposition process , 1991 .

[3]  Jean W. Tom,et al.  Formation of Bioerodible Polymeric Microspheres and Microparticles by Rapid Expansion of Supercritical Solutions , 1991, Biotechnology progress.

[4]  B. Chung,et al.  Concentration of tocopherols from soybean sludge by supercritical carbon dioxide , 1991 .

[5]  W. Pryor Can vitamin E protect humans against the pathological effects of ozone in smog? , 1991, The American journal of clinical nutrition.

[6]  Jean W. Tom,et al.  Particle formation with supercritical fluids—a review , 1991 .

[7]  C. Chow Vitamin E and oxidative stress. , 1991, Free radical biology & medicine.

[8]  J. Mead,et al.  Increased vitamin E content in the lung after ozone exposure: a possible mobilization in response to oxidative stress. , 1990, Archives of biochemistry and biophysics.

[9]  P. Debenedetti Homogeneous nucleation in supercritical fluids , 1990 .

[10]  T. W. Randolph Supercritical fluid extractions in biotechnology. , 1990, Trends in biotechnology.

[11]  A. Randolph,et al.  Precipitation of microsize organic particles from supercritical fluids , 1989 .

[12]  Pablo G. Debenedetti,et al.  Effects of process conditions on crystals obtained from supercritical mixtures , 1989 .

[13]  D. Miller,et al.  Ceramic beams and thin film growth , 1988 .

[14]  Dean W. Matson,et al.  Rapid expansion of supercritical fluid solutions: solute formation of powders, thin films, and fibers , 1987 .

[15]  N. Elsayed Influence of vitamin E on polyamine metabolism in ozone-exposed rat lungs. , 1987, Archives of biochemistry and biophysics.

[16]  H. Loth,et al.  Properties and dissolution of drugs micronized by crystallization from supercritical gases , 1986 .

[17]  K. A. Larson,et al.  Evaluation of Supercritical Fluid Extraction in the Pharmaceutical Industry , 1986, Biotechnology progress.

[18]  N. Elsayed,et al.  Dietary antioxidants and the biochemical response to oxidant inhalation. I. Influence of dietary vitamin E on the biochemical effects of nitrogen dioxide exposure in rat lung. , 1982, Toxicology and applied pharmacology.

[19]  L. Machlin,et al.  KINETICS OF TISSUE α‐TOCOPHEROL UPTAKE AND DEPLETION FOLLOWING ADMINISTRATION OF HIGH LEVELS OF VITAMIN E , 1982, Annals of the New York Academy of Sciences.

[20]  C. Plopper,et al.  Influence of dietary vitamin E on the lungs of ozone-exposed rats: a correlated biochemical and histological study. , 1979, Environmental research.

[21]  D. Hagen,et al.  A liquid chromatographic method for quantitative determination of ?-tocopherol in rat brain , 1977 .

[22]  H. G. Windmueller,et al.  A comparison of the intestinal absorption, lymph and plasma transport, and tissue uptake of -and -tocopherols in the rat. , 1972, Biochimica et biophysica acta.