β‐Microglobulin is Bound to Streptococcal M Protein

The presence of receptors for three human proteins (fibrinogen. IgG, and β2m‐microglobulin (β2m) was studied in group A streptococcal strains, M type 1, 12 and 14, and in M protein‐negative variants of these strains. Fibrinogen binding was detected in all six strains. IgG did not bind to the two type‐12 strains and uptake was low in both type‐14 strains. The type‐1, M protein‐positive strain was negative in binding experiments with radiolabelled IgG, whereas the M protein‐negative variant was strongly positive. Aggregated β2m showed a high degree of reactivity with the M protein‐positive strains but not with the corresponding M protein‐negative variants. The results indicate that the receptor for aggregated β2m is located on M protein in group A streptococci.

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