Controlled actuation of therapeutic nanoparticles: an update on recent progress.

A primary envisioned use for nanoparticles (NPs) in a cellular context is for controlled drug delivery where the full benefit of NP attributes (small size, large drug cargo loading capacity) can improve the pharmacokinetics of the drug cargo. This requires the ability to controllably manipulate the release of the drug cargo from the NP vehicle or 'controlled actuation'. In this review, we highlight new developments in this field from 2013 to 2015. The number and breadth of reports are a testament to the significant advancements made in this field over this time period. We conclude with a perspective of how we envision this field to continue to develop in the years to come.

[1]  Jin-Wook Yoo,et al.  Enzyme/pH dual sensitive polymeric nanoparticles for targeted drug delivery to the inflamed colon. , 2014, Colloids and surfaces. B, Biointerfaces.

[2]  Bin He,et al.  Smart nanovehicles based on pH-triggered disassembly of supramolecular peptide-amphiphiles for efficient intracellular drug delivery. , 2014, Small.

[3]  Jimin Gao,et al.  Near-infrared light remote-controlled intracellular anti-cancer drug delivery using thermo/pH sensitive nanovehicle. , 2015, Acta biomaterialia.

[4]  Qinfu Zhao,et al.  Redox-responsive mesoporous silica as carriers for controlled drug delivery: a comparative study based on silica and PEG gatekeepers. , 2015, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[5]  Woo-Sik Kim,et al.  pH-triggered release of manganese from MnAu nanoparticles that enables cellular neuronal differentiation without cellular toxicity. , 2015, Biomaterials.

[6]  Peng Yang,et al.  Stimuli-responsive biodegradable poly(methacrylic acid) based nanocapsules for ultrasound traced and triggered drug delivery system. , 2014, Biomaterials.

[7]  Dhiman Sarkar,et al.  Graphene quantum dots conjugated albumin nanoparticles for targeted drug delivery and imaging of pancreatic cancer. , 2014, Journal of materials chemistry. B.

[8]  P. de Souza,et al.  Dual-drug delivery of curcumin and platinum drugs in polymeric micelles enhances the synergistic effects: a double act for the treatment of multidrug-resistant cancer. , 2015, Biomaterials science.

[9]  Anjie Dong,et al.  Integrin-targeted zwitterionic polymeric nanoparticles with acid-induced disassembly property for enhanced drug accumulation and release in tumor. , 2014, Biomacromolecules.

[10]  Xianglong Hu,et al.  Photo-Triggered Release of Caged Camptothecin Prodrugs from Dually Responsive Shell Cross-Linked Micelles , 2013 .

[11]  K. Ninomiya,et al.  Targeted and ultrasound-triggered drug delivery using liposomes co-modified with cancer cell-targeting aptamers and a thermosensitive polymer. , 2014, Ultrasonics sonochemistry.

[12]  Christel C. Müller-Goymann,et al.  Nanoparticle-Mediated Pulmonary Drug Delivery: A Review , 2014, International journal of molecular sciences.

[13]  Catherine J. Murphy,et al.  Toxicity and cellular uptake of gold nanoparticles: what we have learned so far? , 2010, Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology.

[14]  Hua He,et al.  Multifunctional graphene quantum dots for simultaneous targeted cellular imaging and drug delivery. , 2014, Colloids and surfaces. B, Biointerfaces.

[15]  Xiao-yan Xie,et al.  Ultrasound-Triggered Phase-Transition Cationic Nanodroplets for Enhanced Gene Delivery. , 2015, ACS applied materials & interfaces.

[16]  Lutz Trahms,et al.  Efficient drug-delivery using magnetic nanoparticles--biodistribution and therapeutic effects in tumour bearing rabbits. , 2013, Nanomedicine : nanotechnology, biology, and medicine.

[17]  Igor L. Medintz,et al.  Multifunctional liquid crystal nanoparticles for intracellular fluorescent imaging and drug delivery. , 2014, ACS nano.

[18]  S. Prabhu,et al.  Silver nanoparticles: mechanism of antimicrobial action, synthesis, medical applications, and toxicity effects , 2012, International Nano Letters.

[19]  Igor L. Medintz,et al.  Active cellular sensing with quantum dots: transitioning from research tool to reality; a review. , 2012, Analytica chimica acta.

[20]  Fred Rieke,et al.  Remote switching of cellular activity and cell signaling using light in conjunction with quantum dots , 2012, Biomedical optics express.

[21]  Tetsuaki Tsuchido,et al.  Mode of Bactericidal Action of Silver Zeolite and Its Comparison with That of Silver Nitrate , 2003, Applied and Environmental Microbiology.

[22]  E. Campo,et al.  Drosophila Embryos as Model to Assess Cellular and Developmental Toxicity of Multi-Walled Carbon Nanotubes (MWCNT) in Living Organisms , 2014, PloS one.

[23]  G. Zhu,et al.  Intracellular antioxidants dissolve man-made antioxidant nanoparticles: using redox vulnerability of nanoceria to develop a responsive drug delivery system. , 2014, ACS applied materials & interfaces.

[24]  Thorsten Verch,et al.  The use of multiple novel tumor biomarkers for the detection of ovarian carcinoma in patients with a pelvic mass. , 2008, Gynecologic oncology.

[25]  S. Ghosh,et al.  Gold Nanocluster Embedded Albumin Nanoparticles for Two-Photon Imaging of Cancer Cells Accompanying Drug Delivery. , 2015, Small.

[26]  V. A. Huu,et al.  Light-responsive nanoparticle depot to control release of a small molecule angiogenesis inhibitor in the posterior segment of the eye. , 2015, Journal of controlled release : official journal of the Controlled Release Society.

[27]  Forrest M Kievit,et al.  Anti-HER2/neu peptide-conjugated iron oxide nanoparticles for targeted delivery of paclitaxel to breast cancer cells. , 2015, Nanoscale.

[28]  M. Bellini,et al.  Protein nanocages for self-triggered nuclear delivery of DNA-targeted chemotherapeutics in Cancer Cells. , 2014, Journal of controlled release : official journal of the Controlled Release Society.

[29]  Angel Orte,et al.  Fluorescent nanoparticles for intracellular sensing: a review. , 2012, Analytica chimica acta.

[30]  F. Bezanilla,et al.  Photosensitivity of Neurons Enabled by Cell-Targeted Gold Nanoparticles , 2015, Neuron.

[31]  Jae-Ho Kim,et al.  Magnetite- and maghemite-induced different toxicity in murine alveolar macrophage cells , 2014, Archives of Toxicology.

[32]  Yasumasa Kato,et al.  Acidic extracellular microenvironment and cancer , 2013, Cancer Cell International.

[33]  M. Roldo.  Carbon nanotubes in drug delivery: just a carrier? , 2016, Therapeutic delivery.

[34]  Igor L. Medintz,et al.  Controlled actuation of therapeutic nanoparticles: moving beyond passive delivery modalities. , 2013, Therapeutic delivery.

[35]  Zhong Luo,et al.  Enzyme responsive mesoporous silica nanoparticles for targeted tumor therapy in vitro and in vivo. , 2015, Nanoscale.

[36]  T. Xia,et al.  Mammalian Cells Exhibit a Range of Sensitivities to Silver Nanoparticles that are Partially Explicable by Variations in Antioxidant Defense and Metallothionein Expression. , 2015, Small.

[37]  Joseph J. Richardson,et al.  Endocytic pH‐Triggered Degradation of Nanoengineered Multilayer Capsules , 2014, Advanced materials.

[38]  M. Hashizume,et al.  Design and Function of Engineered Protein Nanocages as a Drug Delivery System for Targeting Pancreatic Cancer Cells via Neuropilin-1. , 2015, Molecular pharmaceutics.

[39]  Huile Gao,et al.  Matrix metalloproteinase triggered size-shrinkable gelatin-gold fabricated nanoparticles for tumor microenvironment sensitive penetration and diagnosis of glioma. , 2015, Nanoscale.

[40]  Igor L. Medintz,et al.  Controlling the actuation of therapeutic nanomaterials: enabling nanoparticle-mediated drug delivery. , 2013, Therapeutic delivery.

[41]  H. Santos,et al.  Dual-drug delivery by porous silicon nanoparticles for improved cellular uptake, sustained release, and combination therapy. , 2015, Acta biomaterialia.

[42]  Scott Banta,et al.  An unusual cell penetrating peptide identified using a plasmid display-based functional selection platform. , 2011, ACS chemical biology.

[43]  Yan Wang,et al.  Hyaluronic acid oligosaccharide modified redox-responsive mesoporous silica nanoparticles for targeted drug delivery. , 2014, ACS applied materials & interfaces.

[44]  Toshinobu Yogo,et al.  Magnetically Responsive Smart Nanoparticles for Cancer Treatment with a Combination of Magnetic Hyperthermia and Remote-Control Drug Release , 2014, Theranostics.

[45]  Zhigang Suo,et al.  Ultrasound-triggered disruption and self-healing of reversibly cross-linked hydrogels for drug delivery and enhanced chemotherapy , 2014, Proceedings of the National Academy of Sciences.

[46]  Sunny C. Patel,et al.  Graphene-based platforms for cancer therapeutics. , 2016, Therapeutic delivery.

[47]  Cao Xie,et al.  Liposome-based glioma targeted drug delivery enabled by stable peptide ligands. , 2015, Journal of controlled release : official journal of the Controlled Release Society.

[48]  Yong Zhao,et al.  Nano-Gold Corking and Enzymatic Uncorking of Carbon Nanotube Cups , 2014, Journal of the American Chemical Society.

[49]  Y. Liu,et al.  PEGylated mesoporous silica as a redox-responsive drug delivery system for loading thiol-containing drugs. , 2014, International journal of pharmaceutics.

[50]  Robert Ludwig,et al.  Efficient treatment of breast cancer xenografts with multifunctionalized iron oxide nanoparticles combining magnetic hyperthermia and anti-cancer drug delivery , 2015, Breast Cancer Research.

[51]  Mark Borden,et al.  State-of-the-art materials for ultrasound-triggered drug delivery. , 2014, Advanced drug delivery reviews.

[52]  M. Fathy,et al.  Doxorubicin loaded magnetic gold nanoparticles for in vivo targeted drug delivery. , 2015, International journal of pharmaceutics.

[53]  Hossein Afarideh,et al.  Synthesis, characterization and theranostic evaluation of Indium-111 labeled multifunctional superparamagnetic iron oxide nanoparticles. , 2015, Nuclear medicine and biology.

[54]  Yong Chen,et al.  Enzyme-responsive protein/polysaccharide supramolecular nanoparticles. , 2015, Soft matter.

[55]  Igor L. Medintz,et al.  Delivering quantum dots into cells: strategies, progress and remaining issues , 2009, Analytical and bioanalytical chemistry.

[56]  Igor L. Medintz,et al.  In vitro interaction of colloidal nanoparticles with mammalian cells: What have we learned thus far? , 2014, Beilstein journal of nanotechnology.

[57]  Scott H. Medina,et al.  Enzyme-activated nanoconjugates for tunable release of doxorubicin in hepatic cancer cells. , 2013, Biomaterials.

[58]  R. Zare,et al.  Polypyrrole nanoparticles for tunable, pH-sensitive and sustained drug release. , 2015, Nanoscale.

[59]  S. Alarifi,et al.  Evaluation of cytotoxic, oxidative stress, proinflammatory and genotoxic effect of silver nanoparticles in human lung epithelial cells , 2015, Environmental toxicology.

[60]  Jianwen Luo,et al.  Nanohybrid liposomal cerasomes with good physiological stability and rapid temperature responsiveness for high intensity focused ultrasound triggered local chemotherapy of cancer. , 2015, ACS nano.

[61]  G. Storm,et al.  Liposomal delivery of dexamethasone attenuates prostate cancer bone metastatic tumor growth In Vivo , 2015, The Prostate.

[62]  K. Krishnamoorthy,et al.  Green synthesis of silver nanoparticles for selective toxicity towards cancer cells. , 2015, IET nanobiotechnology.

[63]  X. Chen,et al.  Nanosilver: a nanoproduct in medical application. , 2008, Toxicology letters.

[64]  P. Urban,et al.  Immunoliposome-mediated drug delivery to Plasmodium-infected and non-infected red blood cells as a dual therapeutic/prophylactic antimalarial strategy. , 2015, Journal of controlled release : official journal of the Controlled Release Society.

[65]  Jie Yu,et al.  High-throughput synthesis of single-layer MoS2 nanosheets as a near-infrared photothermal-triggered drug delivery for effective cancer therapy. , 2014, ACS nano.

[66]  C. Ménager,et al.  Combining magnetic hyperthermia and photodynamic therapy for tumor ablation with photoresponsive magnetic liposomes. , 2015, ACS nano.

[67]  Jana Drbohlavová,et al.  Modern Micro and Nanoparticle-Based Imaging Techniques , 2012, Sensors.

[68]  Muhammad Ilyas,et al.  Impact of nanoparticles on human and environment: review of toxicity factors, exposures, control strategies, and future prospects , 2015, Environmental Science and Pollution Research.

[69]  Kannan M. Krishnan,et al.  In vivo delivery, pharmacokinetics, biodistribution and toxicity of iron oxide nanoparticles. , 2015, Chemical Society reviews.

[70]  Homan Kang,et al.  Target-specific near-IR induced drug release and photothermal therapy with accumulated Au/Ag hollow nanoshells on pulmonary cancer cell membranes. , 2015, Biomaterials.

[71]  Robert Langer,et al.  Near-infrared–actuated devices for remotely controlled drug delivery , 2014, Proceedings of the National Academy of Sciences.

[72]  W. Pitt,et al.  Ultrasonically triggered drug delivery: breaking the barrier. , 2014, Colloids and surfaces. B, Biointerfaces.

[73]  J. Willmann,et al.  Ultrasound-guided delivery of microRNA loaded nanoparticles into cancer. , 2015, Journal of controlled release : official journal of the Controlled Release Society.

[74]  Yuhong Xu,et al.  Targeting and liposomal drug delivery to CD40L expressing T cells for treatment of autoimmune diseases. , 2015, Journal of controlled release : official journal of the Controlled Release Society.

[75]  M. Amiji,et al.  Redox-responsive targeted gelatin nanoparticles for delivery of combination wt-p53 expressing plasmid DNA and gemcitabine in the treatment of pancreatic cancer , 2014, BMC Cancer.

[76]  Lindsey T. Brinton,et al.  Development of target-specific liposomes for delivering small molecule drugs after reperfused myocardial infarction. , 2015, Journal of controlled release : official journal of the Controlled Release Society.

[77]  P. Netti,et al.  Tumor‐activated prodrug (TAP)‐conjugated nanoparticles with cleavable domains for safe doxorubicin delivery , 2015, Biotechnology and bioengineering.

[78]  H. Fan,et al.  ‘One-pot’ synthesis of multifunctional GSH–CdTe quantum dots for targeted drug delivery , 2014, Nanotechnology.

[79]  Juan B. Blanco-Canosa,et al.  Cellular uptake and fate of PEGylated gold nanoparticles is dependent on both cell-penetration peptides and particle size. , 2011, ACS nano.

[80]  Zhen Gu,et al.  Ultrasound‐Triggered Regulation of Blood Glucose Levels Using Injectable Nano‐Network , 2014, Advanced healthcare materials.

[81]  A J Sinskey,et al.  Oxidized redox state of glutathione in the endoplasmic reticulum. , 1992, Science.

[82]  Lauren A Austin,et al.  XAV939: from a small inhibitor to a potent drug bioconjugate when delivered by gold nanoparticles. , 2014, Bioconjugate chemistry.

[83]  M. Häusser,et al.  Targeting neurons and photons for optogenetics , 2013, Nature Neuroscience.

[84]  Miqin Zhang,et al.  Hexanoyl-Chitosan-PEG Copolymer Coated Iron Oxide Nanoparticles for Hydrophobic Drug Delivery. , 2015, ACS macro letters.

[85]  Jinwoo Cheon,et al.  On-demand drug release system for in vivo cancer treatment through self-assembled magnetic nanoparticles. , 2013, Angewandte Chemie.

[86]  G. Lutty,et al.  Intracellular delivery of dendrimer triamcinolone acetonide conjugates into microglial and human retinal pigment epithelial cells. , 2015, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[87]  S. Choi,et al.  Mechanisms of drug release in nanotherapeutic delivery systems. , 2015, Chemical reviews.

[88]  P. Mascharak,et al.  Incorporation of a ruthenium nitrosyl complex into liposomes, the nitric oxide released from these liposomes and HepG2 cell death mechanism , 2016 .

[89]  Bo Bae Kim,et al.  Self-assembly of biogenic gold nanoparticles and their use to enhance drug delivery into cells. , 2015, Colloids and surfaces. B, Biointerfaces.