In the present study, the numerical investigation has been carried out to see the effects of water mist sprays on the fire suppression mechanism. The special-purposed program named as FDS was used to simulate the interaction of fire plume and water mists. This program solves the fire-driven flows using LES turbulence model, the mixture fraction combustion model, the finite volume method of radiation transport for a non-scattering gray gas, and conjugate heat transfer between wall and gas flow. The computational domain was composed of a rectangular space dimensioned as with a mist-injecting nozzle installed 1.0 m high from the fire pool. In this paper, two types of nozzles were chosen to compare the performance of the fire suppression. Numerical results showed that the nozzle, type A, with more orifices having smaller diameters had poorer performance than the other one, type B because the flow injected through side holes deteriorated the primary flow. The fire-extinguishing time of type A was 2.6 times bigger than that of type B.