Multiple Sclerosis and Spinal-fluid Gamma-globulin

Blood serum and spinal fluid from cases of multiple sclerosis in all stages of the disease and from controls (mainly other neurological conditions) failed to fix complement with an alcoholic brain extract when 5 MHD50 of complement was used. The possible causes of discrepant reports in the literature are briefly discussed. REPEENCES Ahrengot, V. (1957). Acta psychial. scand., 32, 192. Bauer, H., and Heitmann, R. (1958). Dtsch. Z. Nervenheilk., 178, 47. Bornstein. M. B., and Appel, S. H. (1959). Trans. Amer. neurol. Ass., 84, 165. Broman, T., Lidvall, H., Lind, A., and Meyer, P. (1960). Acta psychiat. scand., 35, 403. Dacie, J V. (1956). Practical Haematology, 2nd ed. Churchill, London. Delank, R. W (1957). Arch. Psychiat. Nervtenkr., 195, 383. Field, E. J., and Ridley, A. (1960). Brit. med. J., 2, 1053. Frick, E (1951). Dtsch. Z. Nervenheilk., 166, 54. (1954). Klin. Wschr., 32, 450. Goudie, R. B., Anderson, J. R., and Gray, K. G. (1959). J. Path. Bact., 77. 389. Kabat, E. A., and Mayer, A. A. (1961). Experimental Immunology, 2nd ed. Thomas, Illinois. Kellett, C. E. (1954). Ann. rheum. Dis., 13, 211. Kolb. L. C. (1950). Medicine (Baltimore), 29, 99. Landsteiner, K., and von Eisler, H. (1907). Wein klin. Wschr., 20, 1565. Lumsden, C. E., Kabat, E. A., Wolf, A., and Bezer, A. E. (1950). J. exp. Med., 92, 253. Raskin, N. (1955). Arch. Neurol. Psychiat. (Chic.), 73, 645. Read, C. F., Heilbrunn, G., and Leibert, E. (1939). J. nerv. ment. Dis.. 90. 747. Richardson, G. M. (1941). Lancet, 2, 696. Roemer, G. B., Schrader, A., and Schild, W. (1953). Klin. Wschr., 31, 946. Sachs, H., and Steiner, G. (1934). Ibid., 13, 1714. Sehon, A. H. (1959). In Mechanisms of Hypersensitivity, edited by J. H1. Shaffer, G. A. Lo Grippo, and M. W. Chase. Churchill, London. Stavitsky, A. B., and Arquilla, E. R. (1955). J. Im,nunol., 74, 306.