Endothelium.

Endothelial cells form a subtle monolayer covering the inner surface of the vascular tree. This unique localization allows them to integrate physical and neurohumoral signals from the blood and surrounding tissues to regulate vascular tone, cellular adhesion, inflammation, smooth muscle phenotype and proliferation as well as thromboresistance. Alterations of endothelial atheroprotective functions pave the way for the development of atherosclerotic lesions and their clinical manifestations. Therefore, better understanding the molecular mechanisms shaping up endothelial biology will help design future therapeutic strategies to prevent the development of vascular diseases. Recent publications in Arteriosclerosis, Thrombosis, and Vascular Biology have contributed to understanding several of these important processes.

[1]  J. Rosenblat,et al.  Therapeutic Angiogenesis by Ultrasound-Mediated MicroRNA-126-3p Delivery , 2015, Arteriosclerosis, thrombosis, and vascular biology.

[2]  P. Marsden,et al.  Epigenetics in the Vascular Endothelium: Looking From a Different Perspective in the Epigenomics Era. , 2015, Arteriosclerosis, thrombosis, and vascular biology.

[3]  G. Yan,et al.  Post-Transcriptional Regulation of Endothelial Nitric Oxide Synthase Expression by Polypyrimidine Tract–Binding Protein 1 , 2015, Arteriosclerosis, thrombosis, and vascular biology.

[4]  K. Kaibuchi,et al.  Regulation of Vascular Endothelial Growth Factor Receptor Function in Angiogenesis by Numb and Numb-Like , 2015, Arteriosclerosis, thrombosis, and vascular biology.

[5]  W. Wier,et al.  Reduction of Mitochondria–Endoplasmic Reticulum Interactions by Acetylcholine Protects Human Umbilical Vein Endothelial Cells From Hypoxia/Reoxygenation Injury , 2015, Arteriosclerosis, thrombosis, and vascular biology.

[6]  J. Dunn,et al.  Flow-Dependent Epigenetic DNA Methylation in Endothelial Gene Expression and Atherosclerosis. , 2015, Arteriosclerosis, thrombosis, and vascular biology.

[7]  J. Auwerx,et al.  Protective effects of sirtuins in cardiovascular diseases: from bench to bedside , 2015, European heart journal.

[8]  Yi-zhou Jiang,et al.  Endothelial epigenetics in biomechanical stress: disturbed flow-mediated epigenomic plasticity in vivo and in vitro. , 2015, Arteriosclerosis, thrombosis, and vascular biology.

[9]  S. Erzurum,et al.  Endothelial Uncoupling Protein 2 Regulates Mitophagy and Pulmonary Hypertension During Intermittent Hypoxia , 2015, Arteriosclerosis, thrombosis, and vascular biology.

[10]  R. Adams,et al.  Endothelial Jagged1 Antagonizes Dll4 Regulation of Endothelial Branching and Promotes Vascular Maturation Downstream of Dll4/Notch1 , 2015, Arteriosclerosis, thrombosis, and vascular biology.

[11]  E. Benjamin,et al.  Nonalcoholic fatty liver disease and vascular function: cross-sectional analysis in the Framingham heart study. , 2015, Arteriosclerosis, thrombosis, and vascular biology.

[12]  W. Tian,et al.  Histone Methyltransferase SET1 Mediates Angiotensin II–Induced Endothelin-1 Transcription and Cardiac Hypertrophy in Mice , 2015, Arteriosclerosis, thrombosis, and vascular biology.

[13]  A. Chauhan,et al.  Endothelial PPAR-&ggr; Protects Against Vascular Thrombosis by Downregulating P-Selectin Expression , 2015, Arteriosclerosis, thrombosis, and vascular biology.

[14]  C. Fernández-Hernando,et al.  Endothelial Glucocorticoid Receptor Suppresses Atherogenesis—Brief Report , 2015, Arteriosclerosis, thrombosis, and vascular biology.

[15]  K. Lauber,et al.  Spatiotemporal Expression Dynamics of Selectins Govern the Sequential Extravasation of Neutrophils and Monocytes in the Acute Inflammatory Response , 2015, Arteriosclerosis, thrombosis, and vascular biology.

[16]  C. Napoli,et al.  Epigenetic-related therapeutic challenges in cardiovascular disease. , 2015, Trends in pharmacological sciences.

[17]  O. Soehnlein,et al.  Assessing Large-Vessel Endothelial Permeability Using Near-Infrared Fluorescence Imaging—Brief Report , 2015, Arteriosclerosis, thrombosis, and vascular biology.

[18]  P. Barter,et al.  Cholesteryl Ester Transfer Protein Inhibition Enhances Endothelial Repair and Improves Endothelial Function in the Rabbit , 2015, Arteriosclerosis, thrombosis, and vascular biology.

[19]  A. Zeiher,et al.  Laminar Shear Stress Inhibits Endothelial Cell Metabolism via KLF2-Mediated Repression of PFKFB3 , 2015, Arteriosclerosis, thrombosis, and vascular biology.

[20]  P. Libby,et al.  In Vivo Nanoparticle Assessment of Pathological Endothelium Predicts the Development of Inflow Stenosis in Murine Arteriovenous Fistula , 2015, Arteriosclerosis, thrombosis, and vascular biology.

[21]  J. Fischer,et al.  Measurement of Endothelium-Dependent Vasodilation in Mice—Brief Report , 2014, Arteriosclerosis, thrombosis, and vascular biology.

[22]  I. Bechmann,et al.  Interleukin 17 Drives Vascular Inflammation, Endothelial Dysfunction, and Arterial Hypertension in Psoriasis-Like Skin Disease , 2014, Arteriosclerosis, thrombosis, and vascular biology.

[23]  M. Corada,et al.  Signaling pathways in the specification of arteries and veins. , 2014, Arteriosclerosis, thrombosis, and vascular biology.

[24]  B. Trigatti,et al.  The Effects of Diet on Occlusive Coronary Artery Atherosclerosis and Myocardial Infarction in Scavenger Receptor Class B, Type 1/Low-Density Lipoprotein Receptor Double Knockout Mice , 2014, Arteriosclerosis, thrombosis, and vascular biology.

[25]  J. Abe,et al.  Novel Mechanisms of Endothelial Mechanotransduction , 2014, Arteriosclerosis, thrombosis, and vascular biology.

[26]  T. Massardo,et al.  Atorvastatin Reduces the Proadhesive and Prothrombotic Endothelial Cell Phenotype Induced by Cocaine and Plasma From Cocaine Consumers In Vitro , 2014, Arteriosclerosis, thrombosis, and vascular biology.

[27]  H. Jo,et al.  Role of flow-sensitive microRNAs in endothelial dysfunction and atherosclerosis: mechanosensitive athero-miRs. , 2014, Arteriosclerosis, thrombosis, and vascular biology.

[28]  S. Hsiao,et al.  Mechanoresponsive networks controlling vascular inflammation. , 2014, Arteriosclerosis, thrombosis, and vascular biology.

[29]  N. Yuldasheva,et al.  Haploinsufficiency of the Insulin-Like Growth Factor-1 Receptor Enhances Endothelial Repair and Favorably Modifies Angiogenic Progenitor Cell Phenotype , 2014, Arteriosclerosis, thrombosis, and vascular biology.

[30]  R. Hynes,et al.  Alternative Splicing of Endothelial Fibronectin Is Induced by Disturbed Hemodynamics and Protects Against Hemorrhage of the Vessel Wall , 2014, Arteriosclerosis, thrombosis, and vascular biology.

[31]  M. Gollasch,et al.  Perivascular Adipose Tissue, Potassium Channels, and Vascular Dysfunction , 2014, Arteriosclerosis, thrombosis, and vascular biology.

[32]  S. Peirce,et al.  Monocytes Are Recruited From Venules During Arteriogenesis in the Murine Spinotrapezius Ligation Model , 2014, Arteriosclerosis, thrombosis, and vascular biology.

[33]  M. Cybulsky,et al.  Effect of disturbed blood flow on endothelial cell gene expression: a role for changes in RNA processing. , 2014, Arteriosclerosis, thrombosis, and vascular biology.

[34]  A. Portbury,et al.  NADPH Oxidase–Generated Reactive Oxygen Species Are Required for Stromal Cell–Derived Factor-1&agr;–Stimulated Angiogenesis , 2014, Arteriosclerosis, thrombosis, and vascular biology.

[35]  M. Daemen,et al.  F-Actin–Anchored Focal Adhesions Distinguish Endothelial Phenotypes of Human Arteries and Veins , 2014, Arteriosclerosis, thrombosis, and vascular biology.

[36]  Y. Bergman,et al.  Transcriptional Regulation of Endothelial Arginase 2 by Histone Deacetylase 2 , 2014, Arteriosclerosis, thrombosis, and vascular biology.

[37]  H. Shimokawa,et al.  Endothelial AMP-Activated Protein Kinase Regulates Blood Pressure and Coronary Flow Responses Through Hyperpolarization Mechanism in Mice , 2014, Arteriosclerosis, thrombosis, and vascular biology.

[38]  Lei Yuan,et al.  Endothelial Cell–Specific Expression of Roundabout 4 Is Regulated by Differential DNA Methylation of the Proximal Promoter , 2014, Arteriosclerosis, thrombosis, and vascular biology.

[39]  J. Knuuti,et al.  Pharmacological Activation of the Melanocortin System Limits Plaque Inflammation and Ameliorates Vascular Dysfunction in Atherosclerotic Mice , 2014, Arteriosclerosis, thrombosis, and vascular biology.

[40]  Camilo Aponte-Santamaría,et al.  von Willebrand Factor Directly Interacts With DNA From Neutrophil Extracellular Traps , 2014, Arteriosclerosis, thrombosis, and vascular biology.

[41]  S. Dimmeler,et al.  MicroRNA-126 in atherosclerosis. , 2014, Arteriosclerosis, thrombosis, and vascular biology.

[42]  F. Lenfant,et al.  Determinants of Flow-Mediated Outward Remodeling in Female Rodents: Respective Roles of Age, Estrogens, and Timing , 2014, Arteriosclerosis, thrombosis, and vascular biology.

[43]  A. Quyyumi,et al.  Differences in Vascular Nitric Oxide and Endothelium-Derived Hyperpolarizing Factor Bioavailability in Blacks and Whites , 2014, Arteriosclerosis, thrombosis, and vascular biology.

[44]  C. K. Chong,et al.  Disturbed Flow Promotes Endothelial Senescence via a p53-Dependent Pathway , 2014, Arteriosclerosis, thrombosis, and vascular biology.

[45]  X. Tian,et al.  Metformin Protects Endothelial Function in Diet-Induced Obese Mice by Inhibition of Endoplasmic Reticulum Stress Through 5′ Adenosine Monophosphate–Activated Protein Kinase–Peroxisome Proliferator–Activated Receptor &dgr; Pathway , 2014, Arteriosclerosis, thrombosis, and vascular biology.

[46]  M. Inouye,et al.  Towards a Molecular Systems Model of Coronary Artery Disease , 2014, bioRxiv.

[47]  E. Vittinghoff,et al.  Role of Soluble Endothelial Cell–Selective Adhesion Molecule Biomarker in Albuminuria and Kidney Function Changes in Patients With Coronary Artery Disease: The Heart and Soul Study , 2014, Arteriosclerosis, thrombosis, and vascular biology.

[48]  K. Kwan,et al.  Inhibition of Bone Morphogenic Protein 4 Restores Endothelial Function in db/db Diabetic Mice , 2014, Arteriosclerosis, thrombosis, and vascular biology.

[49]  J. Vita,et al.  Mitochondria and Endothelial Function , 2013, Circulation research.

[50]  S. Voelter-Mahlknecht,et al.  On the epigenetics of vascular regulation and disease , 2012, Clinical Epigenetics.

[51]  V. Wong,et al.  Coronary artery disease and cardiovascular outcomes in patients with non-alcoholic fatty liver disease , 2011, Gut.

[52]  Limei Liu,et al.  Bone Morphogenic Protein-4 Impairs Endothelial Function Through Oxidative Stress–Dependent Cyclooxygenase-2 Upregulation: Implications on Hypertension , 2010, Circulation research.

[53]  J. Balligand,et al.  eNOS activation by physical forces: from short-term regulation of contraction to chronic remodeling of cardiovascular tissues. , 2009, Physiological reviews.

[54]  D. Srivastava,et al.  MicroRNAs: Opening a New Vein in Angiogenesis Research , 2009, Science Signaling.

[55]  P. Vanhoutte,et al.  Endothelial dysfunction: a multifaceted disorder (The Wiggers Award Lecture). , 2006, American journal of physiology. Heart and circulatory physiology.

[56]  A. Zeiher,et al.  Vascular repair by circulating endothelial progenitor cells: the missing link in atherosclerosis? , 2004, Journal of Molecular Medicine.

[57]  P. Ganz,et al.  Testing endothelial vasomotor function: nitric oxide, a multipotent molecule. , 2003, Circulation.

[58]  R. Furchgott,et al.  The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine , 1980, Nature.

[59]  M. Kahn.  A critical role of platelet glycoprotein Ibα in arterial remodeling. , 2015, Arteriosclerosis, thrombosis, and vascular biology.

[60]  HisaoOgawa,et al.  Role of Endothelial Cell–Derived Angptl2 in Vascular Inflammation Leading to Endothelial Dysfunction and Atherosclerosis Progression , 2014 .

[61]  S. Chien,et al.  Shear stress-initiated signaling and its regulation of endothelial function. , 2014, Arteriosclerosis, thrombosis, and vascular biology.