Pharmacological Actions of Neuropeptide Y and Peptide YY in Rat Colon a

Neuropeptide Y (NPY) and peptide YY (PYY) are two related 36 amino acid polypeptides originally isolated from porcine brain and duodenum respectively. Both peptides are present in the gastrointestinal tract, each having its own distinctive cell type and di~tr ibut ion.~.~ Evidence is accumulating that these YY peptides are involved in the regulation of various gastrointestinal functions including neuronal control of motility. It has been proposed that NPY and PYY may interact with a common receptor to induce their action^.^ The aims of this study were therefore 1) to examine and compare the in vitro effects of NPY and PYY on rat distal colon and 2) to establish whether the two peptides activate similar mechanisms.

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