Pancreatic lipase digestion: The forgotten barrier in oral administration of lipid-based delivery systems?

[1]  A. Bernkop‐Schnürch,et al.  Development and in vivo evaluation of nanoemulsions for oral delivery of low molecular weight heparin , 2023, Journal of Drug Delivery Science and Technology.

[2]  Zhenzhong Zhang,et al.  Self‐Thermophoretic Nanoparticles Enhance Intestinal Mucus Penetration and Reduce Pathogenic Bacteria Interception in Colorectal Cancer , 2023, Advanced Functional Materials.

[3]  Chuan-he Tang,et al.  Solid Lipid Nanoparticles (SLNs) and Nanostructured Lipid Carriers (NLCs) as Food-Grade Nanovehicles for Hydrophobic Nutraceuticals or Bioactives , 2023, Applied Sciences.

[4]  A. Paudel,et al.  Lipid-based solubilization technology via hot melt extrusion: promises and challenges , 2022, Expert opinion on drug delivery.

[5]  B. Boyd,et al.  Controlling drug release by introducing lipase inhibitor within a lipid formulation. , 2022, International journal of pharmaceutics.

[6]  Mengyu Chu,et al.  Biological chemotaxis-guided self-thermophoretic nanoplatform augments colorectal cancer therapy through autonomous mucus penetration , 2022, Science advances.

[7]  Milad Taghizadeh,et al.  A state-of-the-art review on the recent advances of niosomes as a targeted drug delivery system. , 2022, International journal of pharmaceutics.

[8]  Phuong Tran,et al.  Alginate-coated chitosan nanoparticles protect protein drugs from acid degradation in gastric media , 2022, Journal of Pharmaceutical Investigation.

[9]  A. Bernkop‐Schnürch,et al.  Digestion of lipid excipients and lipid-based nanocarriers by pancreatic lipase and pancreatin. , 2022, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[10]  S. Matafwali,et al.  Lipid-Based Nanocarriers for Neurological Disorders: A Review of the State-of-the-Art and Therapeutic Success to Date , 2022, Pharmaceutics.

[11]  J. Rosenholm,et al.  Fundamental Aspects of Lipid-Based Excipients in Lipid-Based Product Development , 2022, Pharmaceutics.

[12]  Peng Liu,et al.  A Review of Liposomes as a Drug Delivery System: Current Status of Approved Products, Regulatory Environments, and Future Perspectives , 2022, Molecules.

[13]  F. Dorkoosh,et al.  Oral delivery of therapeutic peptides and proteins: Technology landscape of lipid-based nanocarriers. , 2022, Advanced drug delivery reviews.

[14]  Hongyun Lu,et al.  A Review on Polymer and Lipid-Based Nanocarriers and Its Application to Nano-Pharmaceutical and Food-Based Systems , 2021, Frontiers in Nutrition.

[15]  A. Alexander,et al.  Lipid shell lipid nanocapsules as smart generation lipid nanocarriers , 2021 .

[16]  Chun Li,et al.  The bioavailability of soybean polysaccharides and their metabolites on gut microbiota in the simulator of the human intestinal microbial ecosystem (SHIME). , 2021, Food chemistry.

[17]  U. Haberkorn,et al.  Overcoming the Mucosal Barrier: Tetraether Lipid‐Stabilized Liposomal Nanocarriers Decorated with Cell‐Penetrating Peptides Enable Oral Delivery of Vancomycin , 2021 .

[18]  Ashwani Kumar,et al.  Pancreatic lipase inhibitors: The road voyaged and successes. , 2021, Life sciences.

[19]  S. N.,et al.  A review on pancreatic lipase inhibitors from natural sources: a potential target for obesity , 2021 .

[20]  Niklas J. Koehl,et al.  Exploring the impact of surfactant type and digestion: Highly digestible surfactants improve oral bioavailability of nilotinib. , 2020, Molecular pharmaceutics.

[21]  Qing-Xi Chen,et al.  Lipase Inhibitors for Obesity: A Review. , 2020, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[22]  A. Djeghader,et al.  Modulating the release of pharmaceuticals from lipid cubic phases using a lipase inhibitor. , 2020, Journal of colloid and interface science.

[23]  Xiao Dong Chen,et al.  Current in vitro digestion systems for understanding food digestion in human upper gastrointestinal tract , 2020 .

[24]  Christel A. S. Bergström,et al.  Effect of lipids on absorption of carvedilol in dogs: Is coadministration of lipids as efficient as a lipid-based formulation? , 2019, Journal of controlled release : official journal of the Controlled Release Society.

[25]  Xiao Dong Chen,et al.  An advanced near real dynamic in vitro human stomach system to study gastric digestion and emptying of beef stew and cooked rice. , 2019, Food & function.

[26]  M. Corredig,et al.  INFOGEST static in vitro simulation of gastrointestinal food digestion , 2019, Nature Protocols.

[27]  T. Rades,et al.  In vitro digestion models to evaluate lipid based drug delivery systems; present status and current trends. , 2019, Advanced drug delivery reviews.

[28]  A. Bernkop‐Schnürch,et al.  SEDDS: A game changing approach for the oral administration of hydrophilic macromolecular drugs. , 2019, Advanced drug delivery reviews.

[29]  Christel A. S. Bergström,et al.  Lipolysis-Permeation Setup for Simultaneous Study of Digestion and Absorption in Vitro , 2019, Molecular pharmaceutics.

[30]  Guangbo Ge,et al.  Biflavones from Ginkgo biloba as novel pancreatic lipase inhibitors: Inhibition potentials and mechanism. , 2018, International journal of biological macromolecules.

[31]  R. Carrier,et al.  Engineering the Mucus Barrier. , 2018, Annual review of biomedical engineering.

[32]  M. Gumbleton,et al.  Impact of different hydrophobic ion pairs of octreotide on its oral bioavailability in pigs , 2018, Journal of controlled release : official journal of the Controlled Release Society.

[33]  N. Paul,et al.  Identification and biological activities of carotenoids from the freshwater alga Oedogonium intermedium. , 2018, Food chemistry.

[34]  Christel A. S. Bergström,et al.  Caco-2 Cell Conditions Enabling Studies of Drug Absorption from Digestible Lipid-Based Formulations , 2018, Pharmaceutical Research.

[35]  Choongjin Ban,et al.  Control of the gastrointestinal digestion of solid lipid nanoparticles using PEGylated emulsifiers. , 2018, Food chemistry.

[36]  Xiao Dong Chen,et al.  In vitro gastric digestion of cooked white and brown rice using a dynamic rat stomach model. , 2017, Food chemistry.

[37]  R. Portmann,et al.  Digestion of milk proteins: Comparing static and dynamic in vitro digestion systems with in vivo data. , 2017, Food research international.

[38]  J. Dohnal,et al.  Optimization of Dissolution Compartments in a Biorelevant Dissolution Apparatus Golem v2, Supported by Multivariate Analysis , 2017, Molecules.

[39]  S. Sridhar,et al.  Fungal endophytes associated with Viola odorata Linn. as bioresource for pancreatic lipase inhibitors , 2017, BMC Complementary and Alternative Medicine.

[40]  René Holm,et al.  Simultaneous lipolysis/permeation in vitro model, for the estimation of bioavailability of lipid based drug delivery systems , 2017, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[41]  A. Bernkop‐Schnürch,et al.  Development and in vitro characterization of self-emulsifying drug delivery system (SEDDS) for oral opioid peptide delivery , 2017, Drug development and industrial pharmacy.

[42]  Thomas Rades,et al.  In vitro and in vivo performance of monoacyl phospholipid‐based self‐emulsifying drug delivery systems , 2017, Journal of controlled release : official journal of the Controlled Release Society.

[43]  Xiao Dong Chen,et al.  Enhancement of Digestibility of Casein Powder and Raw Rice Particles in an Improved Dynamic Rat Stomach Model Through an Additional Rolling Mechanism. , 2017, Journal of food science.

[44]  Gergely Hetényi,et al.  Comparison of the protective effect of self-emulsifying peptide drug delivery systems towards intestinal proteases and glutathione. , 2017, International journal of pharmaceutics.

[45]  T. Rades,et al.  High-Throughput Lipolysis in 96-Well Plates for Rapid Screening of Lipid-Based Drug Delivery Systems. , 2017, Journal of pharmaceutical sciences.

[46]  A. Paul,et al.  Bis-indole alkaloids from Tabernaemontana divaricata as potent pancreatic lipase inhibitors: molecular modelling studies and experimental validation , 2017, Medicinal Chemistry Research.

[47]  E. Troncoso,et al.  Development of an in vitro mechanical gastric system (IMGS) with realistic peristalsis to assess lipid digestibility. , 2016, Food research international.

[48]  T. Rades,et al.  Comparison of lipases for in vitro models of gastric digestion: lipolysis using two infant formulas as model substrates. , 2016, Food & function.

[49]  Thomas Rades,et al.  In Situ Lipolysis and Synchrotron Small-Angle X-ray Scattering for the Direct Determination of the Precipitation and Solid-State Form of a Poorly Water-Soluble Drug During Digestion of a Lipid-Based Formulation. , 2016, Journal of pharmaceutical sciences.

[50]  F. D. Zoet,et al.  Effects of inhomogeneity on triglyceride digestion of emulsions using an in vitro digestion model (Tiny TIM). , 2016, Food & function.

[51]  F. Prüfert,et al.  Impact of lipases on the protective effect of SEDDS for incorporated peptide drugs towards intestinal peptidases. , 2016, International journal of pharmaceutics.

[52]  Christel A. S. Bergström,et al.  50years of oral lipid-based formulations: Provenance, progress and future perspectives. , 2016, Advanced drug delivery reviews.

[53]  Jianshe Chen,et al.  Improved emulsifying capabilities of hydrolysates of soy protein isolate pretreated with high pressure microfluidization , 2016 .

[54]  C. Huck,et al.  Development of oral self nano-emulsifying delivery system(s) of lanreotide with improved stability against presystemic thiol-disulfide exchange reactions , 2016, Expert opinion on drug delivery.

[55]  O. Tarawneh,et al.  pH-Dependent Solubility and Dissolution Behavior of Carvedilol—Case Example of a Weakly Basic BCS Class II Drug , 2016, AAPS PharmSciTech.

[56]  A. Bernkop‐Schnürch,et al.  Development and in vitro evaluation of an oral SEDDS for desmopressin , 2016, Drug delivery.

[57]  R. Havenaar,et al.  Evaluation of two dynamic in vitro models simulating fasted and fed state conditions in the upper gastrointestinal tract (TIM-1 and tiny-TIM) for investigating the bioaccessibility of pharmaceutical compounds from oral dosage forms. , 2016, International journal of pharmaceutics.

[58]  F. Carrière,et al.  Relevant pH and lipase for in vitro models of gastric digestion. , 2016, Food & function.

[59]  Nattapong Wongchum,et al.  Screening for anti-pancreatic lipase properties of 28 traditional Thai medicinal herbs , 2015 .

[60]  Q. Sun,et al.  In vitro and in vivo study of fucoxanthin bioavailability from nanoemulsion-based delivery systems: Impact of lipid carrier type , 2015 .

[61]  Thomas Rades,et al.  Development of a high-throughput in vitro intestinal lipolysis model for rapid screening of lipid-based drug delivery systems. , 2015, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[62]  M. Melzig,et al.  Polyphenolic Compounds as Pancreatic Lipase Inhibitors , 2015, Planta Medica.

[63]  P. Gershkovich,et al.  Chain length affects pancreatic lipase activity and the extent and pH-time profile of triglyceride lipolysis. , 2015, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[64]  F. Dorkoosh,et al.  Oral self-nanoemulsifying peptide drug delivery systems: impact of lipase on drug release , 2015, Journal of microencapsulation.

[65]  R. Jachowicz,et al.  Development of In Vitro-In Vivo Correlation/Relationship Modeling Approaches for Immediate Release Formulations Using Compartmental Dynamic Dissolution Data from “Golem”: A Novel Apparatus , 2015, BioMed research international.

[66]  A. Müllertz,et al.  Toward the Establishment of Standardized In Vitro Tests for Lipid-Based Formulations. 5. Lipolysis of Representative Formulations by Gastric Lipase , 2015, Pharmaceutical Research.

[67]  Dae-Duk Kim,et al.  Lyotropic liquid crystal systems in drug delivery: a review , 2015, Journal of Pharmaceutical Investigation.

[68]  Xiao Dong Chen,et al.  Digestive behaviours of large raw rice particles in vivo and in vitro rat stomach systems , 2014 .

[69]  C. Pouton,et al.  'Stealth' lipid-based formulations: poly(ethylene glycol)-mediated digestion inhibition improves oral bioavailability of a model poorly water soluble drug. , 2014, Journal of Controlled Release.

[70]  A. Bernkop‐Schnürch,et al.  Pre-systemic metabolism of orally administered drugs and strategies to overcome it. , 2014, Journal of controlled release : official journal of the Controlled Release Society.

[71]  A. Müllertz,et al.  Toward the Establishment of Standardized In Vitro Tests for Lipid-Based Formulations, Part 6: Effects of Varying Pancreatin and Calcium Levels , 2014, The AAPS Journal.

[72]  Huan Wang,et al.  Exploring the potential of self-assembled mixed micelles in enhancing the stability and oral bioavailability of an acid-labile drug. , 2014, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[73]  Anette Müllertz,et al.  Toward the establishment of standardized in vitro tests for lipid-based formulations, part 4: proposing a new lipid formulation performance classification system. , 2014, Journal of pharmaceutical sciences.

[74]  Christel A. S. Bergström,et al.  Is the full potential of the biopharmaceutics classification system reached? , 2014, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[75]  T. Rades,et al.  In Vitro Lipolysis Data Does Not Adequately Predict the In Vivo Performance of Lipid-Based Drug Delivery Systems Containing Fenofibrate , 2014, The AAPS Journal.

[76]  Martin Kuentz,et al.  Toward an improved understanding of the precipitation behavior of weakly basic drugs from oral lipid-based formulations. , 2014, Journal of pharmaceutical sciences.

[77]  R. Mamluk,et al.  A Novel Suspension Formulation Enhances Intestinal Absorption of Macromolecules Via Transient and Reversible Transport Mechanisms , 2014, Pharmaceutical Research.

[78]  A. Bernkop‐Schnürch,et al.  Strategies for improving mucosal drug delivery. , 2013, Nanomedicine.

[79]  Scott L. Childs,et al.  Formulation of a danazol cocrystal with controlled supersaturation plays an essential role in improving bioavailability. , 2013, Molecular pharmaceutics.

[80]  A. Müllertz,et al.  Toward the Establishment of Standardized In Vitro Tests for Lipid-Based Formulations, Part 3: Understanding Supersaturation Versus Precipitation Potential During the In Vitro Digestion of Type I, II, IIIA, IIIB and IV Lipid-Based Formulations , 2013, Pharmaceutical Research.

[81]  C. Drummond,et al.  Advances in drug delivery and medical imaging using colloidal lyotropic liquid crystalline dispersions. , 2013, Journal of colloid and interface science.

[82]  A. Müllertz,et al.  Toward the establishment of standardized in vitro tests for lipid-based formulations. 2. The effect of bile salt concentration and drug loading on the performance of type I, II, IIIA, IIIB, and IV formulations during in vitro digestion. , 2012, Molecular pharmaceutics.

[83]  M. Kuentz,et al.  In vitro digestion kinetics of excipients for lipid-based drug delivery and introduction of a relative lipolysis half life , 2012, Drug development and industrial pharmacy.

[84]  T. Rades,et al.  Characterising Lipid Lipolysis and Its Implication in Lipid-Based Formulation Development , 2012, The AAPS Journal.

[85]  A. Müllertz,et al.  Toward the establishment of standardized in vitro tests for lipid-based formulations, part 1: method parameterization and comparison of in vitro digestion profiles across a range of representative formulations. , 2012, Journal of pharmaceutical sciences.

[86]  T. Rades,et al.  Influence of lipid composition and drug load on the In Vitro performance of self-nanoemulsifying drug delivery systems. , 2012, Journal of pharmaceutical sciences.

[87]  K. Mohsin Design of Lipid-Based Formulations for Oral Administration of Poorly Water-Soluble Drug Fenofibrate: Effects of Digestion , 2012, AAPS PharmSciTech.

[88]  Juan de Vicente,et al.  Controlling lipolysis through steric surfactants: new insights on the controlled degradation of submicron emulsions after oral and intravenous administration. , 2012, International journal of pharmaceutics.

[89]  F. Carrière,et al.  In Vitro Gastrointestinal Lipolysis: Replacement of Human Digestive Lipases by a Combination of Rabbit Gastric and Porcine Pancreatic Extracts , 2011 .

[90]  David Julian McClements,et al.  Inhibition of lipase-catalyzed hydrolysis of emulsified triglyceride oils by low-molecular weight surfactants under simulated gastrointestinal conditions. , 2011, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[91]  A. Müllertz,et al.  In vitro lipolysis models as a tool for the characterization of oral lipid and surfactant based drug delivery systems. , 2011, International journal of pharmaceutics.

[92]  M. Hudaib,et al.  Pancreatic lipase inhibition activity of trilactone terpenes of Ginkgo biloba , 2011, Journal of enzyme inhibition and medicinal chemistry.

[93]  Susan A. Barker,et al.  Achieving Antral Grinding Forces in Biorelevant In Vitro Models: Comparing the USP Dissolution Apparatus II and the Dynamic Gastric Model with Human In Vivo Data , 2011, AAPS PharmSciTech.

[94]  F. Fotiadu,et al.  Effects of Surfactants on Lipase Structure, Activity, and Inhibition , 2011, Pharmaceutical Research.

[95]  R. Singh,et al.  A human gastric simulator (HGS) to study food digestion in human stomach. , 2010, Journal of food science.

[96]  T. Miyase,et al.  A lipase inhibitor monoterpene and monoterpene glycosides from Monarda punctata. , 2010, Phytochemistry.

[97]  D. Mcclements,et al.  Review of in vitro digestion models for rapid screening of emulsion-based systems. , 2010, Food & function.

[98]  H. Hara,et al.  Suppressive effects of the marine carotenoids, fucoxanthin and fucoxanthinol on triglyceride absorption in lymph duct-cannulated rats , 2010, European journal of nutrition.

[99]  C. Pouton,et al.  Design of lipid-based formulations for oral administration of poorly water-soluble drugs: precipitation of drug after dispersion of formulations in aqueous solution. , 2009, Journal of pharmaceutical sciences.

[100]  F. Carrière,et al.  Continuous measurement of galactolipid hydrolysis by pancreatic lipolytic enzymes using the pH-stat technique and a medium chain monogalactosyl diglyceride as substrate. , 2009, Biochimica et biophysica acta.

[101]  R. Cone,et al.  Barrier properties of mucus. , 2009, Advanced drug delivery reviews.

[102]  Jean-David Rodier,et al.  Lipolysis of the semi-solid self-emulsifying excipient Gelucire 44/14 by digestive lipases. , 2008, Biochimica et biophysica acta.

[103]  Anette Müllertz,et al.  Lipid-based Formulations for Danazol Containing a Digestible Surfactant, Labrafil M2125CS: In Vivo Bioavailability and Dynamic In Vitro Lipolysis , 2008, Pharmaceutical Research.

[104]  Christopher J H Porter,et al.  Formulation of lipid-based delivery systems for oral administration: materials, methods and strategies. , 2008, Advanced drug delivery reviews.

[105]  G. Edwards,et al.  Evaluation of the impact of surfactant digestion on the bioavailability of danazol after oral administration of lipidic self-emulsifying formulations to dogs. , 2008, Journal of pharmaceutical sciences.

[106]  F. Carrière,et al.  A comparative study on two fungal lipases from Thermomyces lanuginosus and Yarrowia lipolytica shows the combined effects of detergents and pH on lipase adsorption and activity. , 2007, Biochimica et biophysica acta.

[107]  K. Bhutani,et al.  Pancreatic lipase inhibitors from natural sources: unexplored potential. , 2007, Drug discovery today.

[108]  Arik Dahan,et al.  The effect of different lipid based formulations on the oral absorption of lipophilic drugs: the ability of in vitro lipolysis and consecutive ex vivo intestinal permeability data to predict in vivo bioavailability in rats. , 2007, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[109]  R. Laugier,et al.  Further biochemical characterization of human pancreatic lipase-related protein 2 expressed in yeast cells Published, JLR Papers in Press, March 30, 2007. , 2007, Journal of Lipid Research.

[110]  B. Bergenståhl,et al.  Morphological observations on a lipid-based drug delivery system during in vitro digestion. , 2007, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[111]  F. Carrière,et al.  Comparative study on digestive lipase activities on the self emulsifying excipient Labrasol, medium chain glycerides and PEG esters. , 2007, Biochimica et biophysica acta.

[112]  Abdelhamid Elaissari,et al.  Colloidal Biomolecules, Biomaterials, and Biomedical Applications , 2007 .

[113]  R. Reifen,et al.  Weight gain reduction in mice fed Panax ginseng saponin, a pancreatic lipase inhibitor. , 2007, Journal of agricultural and food chemistry.

[114]  M. Armand Lipases and lipolysis in the human digestive tract: where do we stand? , 2007, Current opinion in clinical nutrition and metabolic care.

[115]  S. Majumdar,et al.  Drug treatments for obesity: orlistat, sibutramine, and rimonabant , 2007, The Lancet.

[116]  Colin W Pouton,et al.  Formulation of poorly water-soluble drugs for oral administration: physicochemical and physiological issues and the lipid formulation classification system. , 2006, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[117]  F. Carrière,et al.  Exploring the specific features of interfacial enzymology based on lipase studies. , 2006, Biochimica et biophysica acta.

[118]  A. Hoffman,et al.  Use of a Dynamic in Vitro Lipolysis Model to Rationalize Oral Formulation Development for Poor Water Soluble Drugs: Correlation with in Vivo Data and the Relationship to Intra-Enterocyte Processes in Rats , 2006, Pharmaceutical Research.

[119]  S. Petersen,et al.  How gastric lipase, an interfacial enzyme with a Ser-His-Asp catalytic triad, acts optimally at acidic pH. , 2006, Biochemistry.

[120]  R. Verger,et al.  Continuous monitoring of cholesterol oleate hydrolysis by hormone-sensitive lipase and other cholesterol esterases Published, JLR Papers in Press, February 16, 2005. DOI 10.1194/jlr.M400509-JLR200 , 2005, Journal of Lipid Research.

[121]  R. Verger,et al.  Physiology of Gastrointestinal Lipolysis and Therapeutical Use of Lipases and Digestive Lipase Inhibitors , 2005 .

[122]  S. Petry,et al.  Lipases and Phospholipases in Drug Development: From Biochemistry to Molecular Pharmacology , 2005 .

[123]  Ben J. Boyd,et al.  Susceptibility to Lipase-Mediated Digestion Reduces the Oral Bioavailability of Danazol After Administration as a Medium-Chain Lipid-Based Microemulsion Formulation , 2004, Pharmaceutical Research.

[124]  R. Verger,et al.  Might the kinetic behavior of hormone-sensitive lipase reflect the absence of the lid domain? , 2004, Biochemistry.

[125]  I. Trocóniz,et al.  Intestinal absorption of penclomedine from lipid vehicles in the conscious rat: contribution of emulsification versus digestibility. , 2004, International journal of pharmaceutics.

[126]  Ben J Boyd,et al.  Probing drug solubilization patterns in the gastrointestinal tract after administration of lipid-based delivery systems: a phase diagram approach. , 2004, Journal of pharmaceutical sciences.

[127]  D. Lairon,et al.  Mechanisms of Inhibition of Triacylglycerol Hydrolysis by Human Gastric Lipase* , 2002, The Journal of Biological Chemistry.

[128]  Christopher J H Porter,et al.  Evaluation of the in‐vitro digestion profiles of long and medium chain glycerides and the phase behaviour of their lipolytic products , 2002, The Journal of pharmacy and pharmacology.

[129]  L-K Han,et al.  Anti-obesity effects in rodents of dietary teasaponin, a lipase inhibitor , 2001, International Journal of Obesity.

[130]  H. Kristensen,et al.  A dynamic in vitro lipolysis model. II: Evaluation of the model. , 2001, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[131]  C. Abad,et al.  The closed/open model for lipase activation. Addressing intermediate active forms of fungal enzymes by trapping of conformers in water-restricted environments. , 2001, Biochemistry.

[132]  C. Pouton,et al.  Lipid formulations for oral administration of drugs: non-emulsifying, self-emulsifying and 'self-microemulsifying' drug delivery systems. , 2000, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[133]  R. Verger,et al.  Human pancreatic lipase: colipase dependence and interfacial binding of lid domain mutants. , 1999, Biochemistry.

[134]  H. van Tilbeurgh,et al.  Structural basis for the substrate selectivity of pancreatic lipases and some related proteins. , 1998, Biochimica et biophysica acta.

[135]  J.J. Shea,et al.  Surfactants And Polymers In Aqueous Solutions , 1998, IEEE Electrical Insulation Magazine.

[136]  D. Pignol,et al.  Lipase Activation by Nonionic Detergents , 1996, The Journal of Biological Chemistry.

[137]  J. Crison,et al.  A Theoretical Basis for a Biopharmaceutic Drug Classification: The Correlation of in Vitro Drug Product Dissolution and in Vivo Bioavailability , 1995, Pharmaceutical Research.

[138]  Philippe Marteau,et al.  A Multicompartmental Dynamic Computer-controlled Model Simulating the Stomach and Small Intestine , 1995 .

[139]  M. Arisawa,et al.  PANCLICINS, NOVEL PANCREATIC LIPASE INHIBITORS , 1994 .

[140]  G. Olivecrona,et al.  Interactions of lipoprotein lipase with the active-site inhibitor tetrahydrolipstatin (Orlistat). , 1994, European journal of biochemistry.

[141]  H. van Tilbeurgh,et al.  Inactivation of pancreatic lipases by amphiphilic reagents 5-(dodecyldithio)-2-nitrobenzoic acid and tetrahydrolipstatin. Dependence upon partitioning between micellar and oil phases. , 1993, Biochemistry.

[142]  R. Verger,et al.  Secretion and contribution to lipolysis of gastric and pancreatic lipases during a test meal in humans. , 1993, Gastroenterology.

[143]  F. Winkler,et al.  Large spectral changes accompany the conformational transition of human pancreatic lipase induced by acylation with the inhibitor tetrahydrolipstatin. , 1992, European journal of biochemistry.

[144]  R. Verger,et al.  Inactivation of pancreatic and gastric lipases by THL and C12:0-TNB: a kinetic study with emulsified tributyrin. , 1991, Biochimica et biophysica acta.

[145]  R. Verger,et al.  Inactivation of gastric and pancreatic lipases by diethyl p-nitrophenyl phosphate. , 1991, Biochemistry.

[146]  J. Dressman,et al.  Upper Gastrointestinal (GI) pH in Young, Healthy Men and Women , 1990, Pharmaceutical Research.

[147]  L. Sarda,et al.  Human gastric lipase. The effect of amphiphiles. , 1986, European journal of biochemistry.

[148]  D. Cistola,et al.  The Ionization Behavior of Fatty Acids and Bile Acids in Micelles and Membranes , 1984, Hepatology.

[149]  L. Sarda,et al.  Studies on the detergent inhibition of pancreatic lipase activity. , 1983, Journal of lipid research.

[150]  B. Borgstrom,et al.  Interactions of pancreatic lipase with bile salts and dodecyl sulfate. , 1976, Journal of lipid research.

[151]  T. Grauwet,et al.  Lipolysis products formation during in vitro gastric digestion is affected by the emulsion interfacial composition , 2021 .

[152]  R. Prasad,et al.  Therapeutic role of lipases and lipase inhibitors derived from natural resources for remedies against metabolic disorders and lifestyle diseases , 2019, South African Journal of Botany.

[153]  H. Davis,et al.  Ternary Phase Behavior of Mixtures of Siloxane Surfactants, Silicone Oils, and Water , 2019, Silicone Surfactants.

[154]  J. Diaci,et al.  Design of an Innovative Advanced Gastric Simulator , 2019, Dissolution Technologies.

[155]  Xiguang Qi Review of the Clinical Effect of Orlistat , 2018 .

[156]  A. Bernkop‐Schnürch,et al.  Development and in vitro characterisation of an oral self-emulsifying delivery system for daptomycin. , 2016, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[157]  A. Bernkop‐Schnürch,et al.  Mucoadhesive vs. mucopenetrating particulate drug delivery. , 2016, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[158]  T. Rades,et al.  The Effect of Digestion and Drug Load on Halofantrine Absorption from Self-nanoemulsifying Drug Delivery System (SNEDDS) , 2015, The AAPS Journal.

[159]  D. Jonkers,et al.  Prebiotic effects of cassava bagasse in TNO's in vitro model of the colon in lean versus obese microbiota , 2014 .

[160]  I. Raskin,et al.  Effects of a high fat meal matrix and protein complexation on the bioaccessibility of blueberry anthocyanins using the TNO gastrointestinal model (TIM-1). , 2014, Food chemistry.

[161]  M. Nakajima,et al.  Development of a Human Gastric Digestion Simulator Equipped with Peristalsis Function for the Direct Observation and Analysis of the Food Digestion Process , 2014 .

[162]  F. Carrière,et al.  Understanding the lipid-digestion processes in the GI tract before designing lipid-based drug-delivery systems. , 2012, Therapeutic delivery.

[163]  M. Wickham,et al.  The Design, Operation, and Application of a Dynamic Gastric Model , 2012 .

[164]  M. Wahlgren,et al.  Protein adsorption to solid surfaces. , 1991, Trends in biotechnology.