Respiratory disease of the bovine neonate.

Respiratory disease is an important problem in bovine neonates. Early detection of clinical disease is challenging. In the newborn calf, mucous membrane color, character and frequency of the respiratory effort, thoracic auscultation, and ability to oxygenate are critical elements of the examination to determine whether or not respiratory disease is present. Within a few days of birth, screening calves for fever, abnormal nasal or ocular discharge, or an inducible cough finds many calves with early respiratory disease. This article describes respiratory conditions in newborn calves that veterinarians are most likely to encounter, along with diagnostic and treatment options that can be applied to both herd investigations and individual animals.

[1]  A. Spitzer,et al.  Exudative lung injury is associated with decreased levels of surfactant proteins in a rat model of meconium aspiration. , 1997, Pediatrics.

[2]  J. Davis,et al.  Pulmonary hypertension and persistent fetal circulation in the newborn. , 1988, Clinics in perinatology.

[3]  R. Bing Diseases of the cardiovascular system. , 1953, Annual review of medicine.

[4]  R. Kravitz Congenital malformations of the lung. , 1994, Pediatric clinics of North America.

[5]  S. Peek,et al.  Pneumothorax in dairy cattle: 30 cases (1990-2003). , 2004, Journal of the American Veterinary Medical Association.

[6]  P. Monget,et al.  Clinical, Hormonal, and Hematologic Characteristics of Bovine Calves Derived from Nuclei from Somatic Cells , 2002, Biology of reproduction.

[7]  S. Mcguirk Disease Management of Dairy Calves and Heifers , 2008, Veterinary Clinics of North America: Food Animal Practice.

[8]  Matthew W. Miller,et al.  Clinical and pathologic features of cloned transgenic calves and fetuses (13 case studies). , 1999, Theriogenology.

[9]  T. Yeh,et al.  The role of pulmonary inflammation in the development of pulmonary hypertension in newborn with meconium aspiration syndrome (MAS) , 1999, Pediatric pulmonology. Supplement.

[10]  F. Douce,et al.  Effects of syringe material, sample storage time, and temperature on blood gases and oxygen saturation in arterialized human blood samples. , 2006, Respiratory care.

[11]  C. Guard,et al.  Diseases of Dairy Cattle , 1995 .

[12]  P. Singh,et al.  Detection of Salmonella dublin mammary gland infection in carrier cows, using an enzyme-linked immunosorbent assay for antibody in milk or serum. , 1989, American journal of veterinary research.

[13]  H. Sagara [Infectious diseases of the gastrointestinal tract]. , 1990, Nihon rinsho. Japanese journal of clinical medicine.

[14]  Y. Schukken,et al.  Herd Health and Production Management in Dairy Practice , 1998 .

[15]  S. Mcguirk,et al.  Management of pneumothorax in cattle by continuous-flow evacuation. , 2003, Journal of Veterinary Internal Medicine.

[16]  D Waltner-Toews,et al.  The effect of early calfhood health status on survivorship and age at first calving. , 1986, Canadian journal of veterinary research = Revue canadienne de recherche veterinaire.

[17]  J. Severinghaus,et al.  Regulation of respiration (first of three parts). , 1977, The New England journal of medicine.

[18]  Y. Kato,et al.  Recent progress and problems in animal cloning. , 2002, Differentiation; research in biological diversity.

[19]  L. Reid,et al.  Normal postnatal development of the media of the rat hilar pulmonary artery and its remodeling by chronic hypoxia. , 1982, Laboratory investigation; a journal of technical methods and pathology.

[20]  O. Szenci,et al.  Improved pulmonary adaptation in newborn calves with postnatal acidosis. , 2001, Veterinary journal.

[21]  G. Schuijt Iatrogenic fractures of ribs and vertebrae during delivery in perinatally dying calves: 235 cases (1978-1988). , 1990, Journal of the American Veterinary Medical Association.

[22]  P. Kero,et al.  Meconium aspiration induces ARDS‐like pulmonary response in lungs of ten‐week‐old pigs , 1997, Pediatric pulmonology.

[23]  J. Cloherty Manual of Neonatal Care , 1991 .

[24]  R. Steinhorn Neonatal pulmonary hypertension , 2010, Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.

[25]  L. McDuffee Manual of Equine Emergencies , 1999 .

[26]  P. Lekeux,et al.  Evaluation of accuracy of pulse oximetry in newborn calves. , 2000, Veterinary journal.

[27]  L. Liu,et al.  [The study of effect of pain in the change of respiration by stimulating "renzhong" acupoint]. , 1990, Zhen ci yan jiu = Acupuncture research.

[28]  L. Bush,et al.  Two methods for administering colostrum to newborn calves. , 1985, Journal of dairy science.

[29]  A. Sola,et al.  Oral Sildenafil in Infants With Persistent Pulmonary Hypertension of the Newborn: A Pilot Randomized Blinded Study , 2006, Pediatrics.

[30]  C. A. Zittle Precipitation of Caprine and Bovine Caseins from Acidic Solutions by Sodium Polyphosphate: Influence of pH and Urea. Utilization for Separation of αs- and κ-caseins , 1967 .

[31]  B. Robertson,et al.  Surfactant inhibition in experimental meconium aspiration , 1993, Acta paediatrica.

[32]  B. Aldridge,et al.  Arterial blood sample collection from the newborn calf , 2004, Veterinary Research Communications.

[33]  S. Martin,et al.  The frequency, distribution and effects of antibodies, to seven putative respiratory pathogens, on respiratory disease and weight gain in feedlot calves in Ontario. , 1989, Canadian journal of veterinary research = Revue canadienne de recherche veterinaire.

[34]  W. Sterling Edwards,et al.  Blood Vessels , 1959 .

[35]  G. Fecteau,et al.  Bacteriological culture of blood from critically ill neonatal calves. , 1997, The Canadian veterinary journal = La revue veterinaire canadienne.

[36]  H. Erb,et al.  The relationship of calfhood morbidity with survival after calving in 25 New York Holstein herds. , 1997, Preventive veterinary medicine.

[37]  J. Hill,et al.  Placental anomalies in a viable cloned calf. , 2001, Cloning.

[38]  J. Davis,et al.  Meconium aspiration syndrome: Physiological and inflammatory changes in a newborn piglet model , 1993, Pediatric pulmonology.

[39]  J. Roy Management of health , 1990 .

[40]  R. Klein,et al.  Autoradiographic analysis of cell proliferation and protein synthesis in the pulmonary trunk of rats during the early development of hypoxia-induced pulmonary hypertension. , 1984, Blood vessels.

[41]  I R Dohoo,et al.  Calf and disease factors affecting growth in female Holstein calves in Florida, USA. , 1998, Preventive veterinary medicine.

[42]  S. Kalhan,et al.  Meconium Aspiration Syndrome: Intrapartum and Neonatal Attributes , 1990, American journal of obstetrics and gynecology.

[43]  W. Walsh,et al.  Surfactant Lavage in a Piglet Model of Meconium Aspiration Syndrome , 1992, Pediatric Research.

[44]  Bradford P. Smith Large Animal Internal Medicine , 1990 .

[45]  R. Streeter,et al.  Isolation of Mycobacterium paratuberculosis from colostrum and milk of subclinically infected cows. , 1995, American journal of veterinary research.

[46]  K. Nordlund Practical considerations for ventilating calf barns in winter. , 2008, The Veterinary clinics of North America. Food animal practice.

[47]  D. G. Wyatt,et al.  The effect of ventilation of the foetal lungs upon the pulmonary circulation , 1952, The Journal of physiology.

[48]  T. Besser,et al.  Comparison of three methods of feeding colostrum to dairy calves. , 1991, Journal of the American Veterinary Medical Association.

[49]  R. Chandra,et al.  Persistent pulmonary hypertension of the newborn: pulmonary pathologic aspects. , 1988, Perspectives in pediatric pathology.

[50]  P. Spitale,et al.  Inhibition of pulmonary surfactant function by meconium. , 1991, American journal of obstetrics and gynecology.

[51]  L. Shekerdemian,et al.  Intravenous sildenafil lowers pulmonary vascular resistance in a model of neonatal pulmonary hypertension. , 2002, American journal of respiratory and critical care medicine.

[52]  V. Sloss,et al.  Anoxia in the bovine foetus. , 1977, Australian veterinary journal.

[53]  B. Carey Neonatal Air Leaks: Pneumothorax, Pneumomediastinum, Pulmonary Interstitial Emphysema, Pneumopericardium , 1999, Neonatal Network.

[54]  M. Apley,et al.  In Vitro Antimicrobial Inhibition Profiles of Mycoplasma Bovis Isolates Recovered from Various Regions of the United States from 2002 to 2003 , 2005, Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc.

[55]  B. Tennant,et al.  Infectious Diseases of the Gastrointestinal Tract , 2008, Rebhun's Diseases of Dairy Cattle.

[56]  M. Tronchin,et al.  Brain Hemodynamic Effects of Doxapram in Preterm Infants , 2006, Neonatology.

[57]  M. Taverne,et al.  The interval between birth and sternal recumbency as an objective measure of the vitality of newborn calves , 1994, Veterinary Record.

[58]  N. Voelkel,et al.  Severe pulmonary hypertension and arterial adventitial changes in newborn calves at 4,300 m. , 1987, Journal of applied physiology.

[59]  P. D. De Leyn,et al.  Congenital Parenchymatous Malformations of the Lung , 1999, World Journal of Surgery.

[60]  B. Aldridge,et al.  Neonatal septicemia in calves: 25 cases (1985-1990). , 1993, Journal of the American Veterinary Medical Association.

[61]  M. Paradis Equine neonatal medicine : a case-based approach , 2006 .

[62]  M. Payton,et al.  Bovine viral diarrhea virus (BVDV) 1b: predominant BVDV subtype in calves with respiratory disease. , 2002, Canadian journal of veterinary research = Revue canadienne de recherche veterinaire.

[63]  S. Robertson,et al.  Comparison of the effects of caffeine and doxapram on respiratory and cardiovascular function in foals with induced respiratory acidosis. , 2007, American journal of veterinary research.

[64]  M. C. Rogers,et al.  Effect of intra‐alveolar meconium on pulmonary surface tension properties , 1985, Critical care medicine.

[65]  F. Cheney,et al.  Mechanical and chemical damage to lung tissue caused by meconium aspiration. , 1978, Pediatrics.

[66]  R. Comline,et al.  Some aspects of foetal and uteroplacental metabolism in cows with indwelling umbilical and uterine vascular catheters. , 1976, The Journal of physiology.

[67]  T. R. Kasari Physiologic mechanisms of adaptation in the fetal calf at birth. , 1994, The Veterinary clinics of North America. Food animal practice.

[68]  O. Nagy,et al.  The effect of arterial blood sampling sites on blood gases and acid-base balance parameters in calves. , 2001, Acta veterinaria Hungarica.

[69]  S. Czarnecki,et al.  The occurrence of primary pulmonary hypertension in twins with a review of etiological considerations. , 1968, American heart journal.

[70]  L. Reid,et al.  Hypoxia and incorporation of 3H-thymidine by cells of the rat pulmonary arteries and alveolar wall. , 1979, The American journal of pathology.

[71]  M. Mazan 8 – Noninfectious Respiratory Problems , 2006 .

[72]  J. Murphy,et al.  The structural basis of persistent pulmonary hypertension of the newborn infant. , 1981, The Journal of pediatrics.

[73]  G. Peckham,et al.  The Clinical Profile of the Newborn with Persistent Pulmonary Hypertension , 1977, Clinical pediatrics.

[74]  C. Polan,et al.  Influence of administered indigenous microorganisms on uptake of [iodine-125] gamma-globulin in vivo by intestinal segments of neonatal calves. , 1981, Journal of dairy science.

[75]  R. Gardiner Cerebral blood flow and oxidative metabolism during hypoxia and asphyxia in the new‐born calf and lamb. , 1980, The Journal of physiology.

[76]  R. Schumacher,et al.  Treatment of Apnea of Prematurity , 2003, Paediatric drugs.

[77]  R. Bildfell,et al.  Pulmonary Inflammation Associated with Aspirated Meconium and Epithelial Cells in Calves , 1992, Veterinary pathology.

[78]  J. Renard,et al.  Frequency and Occurrence of Late-Gestation Losses from Cattle Cloned Embryos , 2002, Biology of reproduction.

[79]  T. Larmi,et al.  [Regulation of respiration]. , 1954, Duodecim; laaketieteellinen aikakauskirja.

[80]  L. Potgieter,et al.  Immunology of bovine viral diarrhea virus. , 1995, The Veterinary clinics of North America. Food animal practice.

[81]  B. Robertson,et al.  Surfactant improves lung function and morphology in newborn rabbits with meconium aspiration. , 1993, Biology of the neonate.

[82]  S. Martin,et al.  The associations of viral and mycoplasmal antibody titers with respiratory disease and weight gain in feedlot calves. , 1999, The Canadian veterinary journal = La revue veterinaire canadienne.

[83]  C. Bredenberg,et al.  Surfactant displacement by meconium free fatty acids: an alternative explanation for atelectasis in meconium aspiration syndrome. , 1987, The Journal of pediatrics.

[84]  J. Cullor,et al.  Persistent experimental Salmonella dublin intramammary infection in dairy cows. , 1991, Journal of veterinary internal medicine.

[85]  Melvin J Swenson,et al.  Dukes' Physiology of domestic animals , 1942 .

[86]  U. Bleul,et al.  Monitoring the bovine fetus during stage II of parturition using pulse oximetry. , 2008, Theriogenology.

[87]  N. Cook,et al.  Calf respiratory disease and pen microenvironments in naturally ventilated calf barns in winter. , 2005, Journal of dairy science.

[88]  P. Wilkins Lower respiratory problems of the neonate. , 2003, The Veterinary clinics of North America. Equine practice.

[89]  K. Walser,et al.  [Blood gases and acid-base equilibrium of viable calves within the 1st 24 hours of life]. , 1977, Berliner und Munchener tierarztliche Wochenschrift.

[90]  C. Cebra,et al.  What is your diagnosis? Pulmonary bullous emphysema with pneumothorax and subcutaneous emphysema. , 1999, Journal of the American Veterinary Medical Association.

[91]  I. Page,et al.  Diseases of the cardiovascular system. , 1951, Annual review of medicine.

[92]  R. Harding,et al.  The regulation of flow of pulmonary fluid in fetal sheep. , 1984, Respiration physiology.

[93]  D. Hurley,et al.  Neonatal Immune Development in the Calf and Its Impact on Vaccine Response , 2008, Veterinary Clinics of North America: Food Animal Practice.

[94]  J. Lavoie,et al.  Effects of syringe type and storage temperature on results of blood gas analysis in arterial blood of horses. , 2007, Journal of veterinary internal medicine.

[95]  O. Szenci Role of acid-base disturbances in perinatal mortality of calves. , 2003, Acta veterinaria Hungarica.

[96]  L. Bush,et al.  Receptor mechanisms of the neonatal intestine and their relationship to immunoglobulin absorption and disease. , 1985, Journal of dairy science.

[97]  C. Cottrill,et al.  Persistence of foetal circulatory pathways in a newborn foal. , 1987, Equine veterinary journal.

[98]  E. Grunert,et al.  Vergleich von arteriellen und venösen Blutgas‐ und Säurebasenwerten bei zu früh geborenen gesunden oder an einer Spätasphyxie erkrankten Kälbern1 , 1989 .

[99]  T. Wiswell,et al.  Meconium staining and the meconium aspiration syndrome. Unresolved issues. , 1993, Pediatric clinics of North America.

[100]  J. Saliki,et al.  Bovine viral diarrhea viral infections in feeder calves with respiratory disease: interactions with Pasteurella spp., parainfluenza-3 virus, and bovine respiratory syncytial virus. , 2000, Canadian journal of veterinary research = Revue canadienne de recherche veterinaire.

[101]  U. Bleul,et al.  Blood gas and acid-base analysis of arterial blood in 57 newborn calves , 2007, Veterinary Record.

[102]  H. Erb,et al.  Path model of individual-calf risk factors for calfhood morbidity and mortality in New York Holstein herds☆ , 1988 .

[103]  T. Wiswell,et al.  Meconium-stained amniotic fluid and the meconium aspiration syndrome. An update. , 1998, Pediatric clinics of North America.

[104]  J. Palmer,et al.  Neonatal care of high-risk cloned and transgenic calves. , 2005, The Veterinary clinics of North America. Food animal practice.

[105]  D. Plumb Veterinary Drug Handbook , 1999 .

[106]  R. Sweeney,et al.  Mycobacterium paratuberculosis cultured from milk and supramammary lymph nodes of infected asymptomatic cows , 1992, Journal of clinical microbiology.

[107]  B. Richardson,et al.  Blood flow and oxygen delivery to fetal organs and tissues during sustained hypoxemia. , 1990, The American journal of physiology.

[108]  S. Messier,et al.  Determination of Mycoplasma bovis susceptibilities against six antimicrobial agents using the E test method. , 2005, Veterinary microbiology.

[109]  O. Szenci,et al.  Comparison between pre- and postnatal acid-base status of calves and their perinatal mortality. , 1988, The Veterinary quarterly.