Preferences of women facing a prenatal diagnostic choice: long‐term outcomes matter most

Women aged 35 or older who wish to undergo prenatal diagnosis for chromosomal disorders are typically offered a choice between chorionic villus sampling or amniocentesis. These two tests are performed at different times and impose differing miscarriage risks. In deciding which test to use, therefore, women need to consider both short‐term consequences (e.g. timing of pregnancy loss, should it occur) and long‐term consequences (e.g. whether a pregnancy loss is followed by a future birth). We examined how women seeking prenatal diagnostic services value the outcomes of testing.

[1]  S. Tunis,et al.  Patterns of mood states in pregnant women undergoing chorionic villus sampling or amniocentesis. , 1990, American journal of medical genetics.

[2]  M. Olmsted,et al.  Anxiety reduction after chorionic villus sampling and genetic amniocentesis. , 1988, American journal of obstetrics and gynecology.

[3]  T. Stijnen,et al.  Reproductive behaviour following spontaneous loss of a pregnancy after prenatal diagnosis , 1992, Clinical genetics.

[4]  M. Kuppermann,et al.  Racial‐Ethnic Differences in Prenatal Diagnostic Test Use and Outcomes: Preferences, Socioeconomics, or Patient Knowledge? , 1996, Obstetrics and gynecology.

[5]  M. Weinstein,et al.  Clinical Decision Analysis , 1980 .

[6]  P. Heckerling,et al.  Preferences of pregnant women for amniocentesis or chorionic villus sampling for prenatal testing: comparison of patients' choices and those of a decision-analytic model. , 1994, Journal of clinical epidemiology.

[7]  W. Sanger,et al.  Utilization of prenatal genetic diagnosis in women 35 years of age and older in the United States, 1977 to 1978. , 1981, American journal of obstetrics and gynecology.

[8]  J. Wladimiroff,et al.  Reproductive behaviour and prenatal diagnosis following genetic termination of pregnancy in women of advanced maternal age , 1992, Prenatal diagnosis.

[9]  G. Robinson,et al.  Impact of prenatal testing on maternal-fetal bonding: chorionic villus sampling versus amniocentesis. , 1991, American journal of obstetrics and gynecology.

[10]  R. Penketh,et al.  Uptake of amniocentesis in women aged 38 years or more by the time of the expected date of delivery: a two‐year retrospective study , 1986, British journal of obstetrics and gynaecology.

[11]  N. Uddenberg,et al.  Prenatal diagnosis and psychological distress: Amniocentesis or chorionic villus biopsy? , 1989, Prenatal diagnosis.

[12]  JW Spencer,et al.  Emotional Responses of Pregnant Women to Chorionic Villi Sampling or Amniocentesis , 1987, American journal of obstetrics and gynecology.

[13]  J. Hamerton,et al.  Canadian multicentre randomized clinical trial of chorion villus sampling and amniocentesis: Final report , 1992, Prenatal diagnosis.

[14]  Spencer Jw,et al.  A comparison of chorionic villi sampling and amniocentesis: acceptability of procedure and maternal attachment to pregnancy. , 1988 .

[15]  D. Danks,et al.  New estimates of down syndrome risks at chorionic villus sampling, amniocentesis, and livebirth in women of advanced maternal age from a uniquely defined population , 1995, Prenatal diagnosis.

[16]  B. Brambati,et al.  Genetic diagnosis by chorionic villus sampling before 8 gestational weeks: Efficiency, reliability, and risks on 317 completed pregnancies , 1992, Prenatal diagnosis.

[17]  D. Ledbetter,et al.  The safety and efficacy of chorionic villus sampling for early prenatal diagnosis of cytogenetic abnormalities. , 1989, The New England journal of medicine.

[18]  M. Kuppermann,et al.  Can Preference Scores for Discrete States Be Used to Derive Preference Scores for an Entire Path of Events? , 1997, Medical decision making : an international journal of the Society for Medical Decision Making.

[19]  R. Kane,et al.  Methodology for measuring health-state preferences--II: Scaling methods. , 1989, Journal of clinical epidemiology.