Reversal of neurosteroid effects at α4β2δ GABAA receptors triggers anxiety at puberty

[1]  Erminio Costa,et al.  Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis , 2006, Proceedings of the National Academy of Sciences.

[2]  K. Light,et al.  Ethnic differences in allopregnanolone concentrations in women during rest and following mental stress. , 2006, Psychophysiology.

[3]  K. L. Perkins,et al.  Cell-attached voltage-clamp and current-clamp recording and stimulation techniques in brain slices , 2006, Journal of Neuroscience Methods.

[4]  G. Homanics,et al.  Steroid withdrawal in the mouse results in anxiogenic effects of 3α,5β-THP: a possible model of premenstrual dysphoric disorder , 2006, Psychopharmacology.

[5]  David E. Clapham,et al.  A voltage-gated proton-selective channel lacking the pore domain , 2006, Nature.

[6]  D. Bayliss,et al.  Inhibition of a background potassium channel by Gq protein α-subunits , 2006 .

[7]  J. Lambert,et al.  Extrasynaptic GABAA Receptors of Thalamocortical Neurons: A Molecular Target for Hypnotics , 2005, The Journal of Neuroscience.

[8]  J. Raymond,et al.  Interaction of Calmodulin with the Serotonin 5-Hydroxytryptamine2A Receptor , 2005, Journal of Biological Chemistry.

[9]  B. McEwen.  Stressed or stressed out: what is the difference? , 2005, Journal of psychiatry & neuroscience : JPN.

[10]  I. Módy,et al.  Ovarian cycle–linked changes in GABAA receptors mediating tonic inhibition alter seizure susceptibility and anxiety , 2005, Nature Neuroscience.

[11]  M. Bixo,et al.  Relationship between allopregnanolone and negative mood in postmenopausal women taking sequential hormone replacement therapy with vaginal progesterone , 2005, Psychoneuroendocrinology.

[12]  G. Biggio,et al.  Increased expression of the gene for the Y1 receptor of neuropeptide Y in the amygdala and paraventricular nucleus of Y1R/LacZ transgenic mice in response to restraint stress , 2004, Journal of neurochemistry.

[13]  B. Orser,et al.  Tonic inhibition in mouse hippocampal CA1 pyramidal neurons is mediated by α5 subunit-containing γ-aminobutyric acid type A receptors , 2004 .

[14]  I. Módy,et al.  Neuroactive steroids reduce neuronal excitability by selectively enhancing tonic inhibition mediated by δ subunit-containing GABAA receptors , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[15]  T. Bäckström,et al.  Allopregnanolone-stimulated GABA-mediated chloride ion flux is inhibited by 3β-hydroxy-5α-pregnan-20-one (isoallopregnanolone) , 2003, Brain Research.

[16]  E. Kirkness,et al.  A cytoplasmic region determines single-channel conductance in 5-HT3 receptors , 2003, Nature.

[17]  Y. Fujiyoshi,et al.  Structure and gating mechanism of the acetylcholine receptor pore , 2003, Nature.

[18]  S. Prescott,et al.  Gain control of firing rate by shunting inhibition: Roles of synaptic noise and dendritic saturation , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[19]  C. Frye,et al.  Allopregnanolone Levels and Symptom Improvement in Severe Premenstrual Syndrome , 2002, Journal of clinical psychopharmacology.

[20]  J. Lambert,et al.  The influence of subunit composition on the interaction of neurosteroids with GABAA receptors , 2002, Neuropharmacology.

[21]  M. Bianchi,et al.  α1 and α6 subunits specify distinct desensitization, deactivation and neurosteroid modulation of GABAA receptors containing the δ subunit , 2002, Neuropharmacology.

[22]  K. Williams,et al.  Hormonally regulated α4β2δ GABAA receptors are a target for alcohol , 2002, Nature Neuroscience.

[23]  I. Módy,et al.    Receptors with Different Affinities Mediate Phasic and Tonic GABAA Conductances in Hippocampal Neurons , 2002, The Journal of Neuroscience.

[24]  C. Hayward,et al.  Puberty and the emergence of gender differences in psychopathology. , 2002, The Journal of adolescent health : official publication of the Society for Adolescent Medicine.

[25]  W Wang,et al.  GABA Transaminase Inhibition Induces Spontaneous and Enhances Depolarization-Evoked GABA Efflux via Reversal of the GABA Transporter , 2001, The Journal of Neuroscience.

[26]  B. Orser,et al.  Distinct functional and pharmacological properties of tonic and quantal inhibitory postsynaptic currents mediated by gamma-aminobutyric acid(A) receptors in hippocampal neurons. , 2001, Molecular pharmacology.

[27]  M. Sanguinetti,et al.  Functional Roles of Charged Residues in the Putative Voltage Sensor of the HCN2 Pacemaker Channel* , 2000, The Journal of Biological Chemistry.

[28]  D. Bitrán,et al.  Anxiolytic effects of the neuroactive steroid pregnanolone (3α-OH-5β-pregnan-20-one) after microinjection in the dorsal hippocampus and lateral septum , 1999, Brain Research.

[29]  J. Benson,et al.  Benzodiazepine actions mediated by specific γ-aminobutyric acidA receptor subtypes , 1999, Nature.

[30]  K. Staley,et al.  Modulation of mammalian dendritic GABAA receptor function by the kinetics of Cl− and HCO3− transport , 1999, The Journal of physiology.

[31]  S. Bernasconi,et al.  Changes of Serum Allopregnanolone Levels in the First 2 Years of Life and during Pubertal Development , 1999, Pediatric Research.

[32]  R. Macdonald,et al.  GABAA receptor subunit γ2 and δ subtypes confer unique kinetic properties on recombinant GABAA receptor currents in mouse fibroblasts , 1999 .

[33]  F. Hsu,et al.  GABAA receptor α4 subunit suppression prevents withdrawal properties of an endogenous steroid , 1998, Nature.

[34]  D. Rubinow,et al.  Differential behavioral effects of gonadal steroids in women with and in those without premenstrual syndrome. , 1998, The New England journal of medicine.

[35]  B. E. Collins,et al.  Brain neurosteroids during the mouse oestrous cycle , 1997, Brain Research.

[36]  J R Huguenard,et al.  Nucleus-Specific Chloride Homeostasis in Rat Thalamus , 1997, The Journal of Neuroscience.

[37]  D. S. Weiss,et al.  Stoichiometry of a Recombinant GABAA Receptor , 1996, The Journal of Neuroscience.

[38]  G. Gensini,et al.  Changes in Blood Pressure Reactivity and 24-Hour Blood Pressure Profile Occurring at Puberty , 1994, Angiology.

[39]  C. Labrid.  Changes in blood pressure reactivity and 24-hour blood pressure profile occurring at puberty. , 1994 .

[40]  S. Paul,et al.  Anxiolytic metabolites of progesterone: correlation with mood and performance measures following oral progesterone administration to healthy female volunteers. , 1993, Neuroendocrinology.

[41]  I. Módy,et al.  Shunting of excitatory input to dentate gyrus granule cells by a depolarizing GABAA receptor-mediated postsynaptic conductance. , 1992, Journal of neurophysiology.

[42]  W Wisden,et al.  The distribution of 13 GABAA receptor subunit mRNAs in the rat brain. I. Telencephalon, diencephalon, mesencephalon , 1992, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[43]  T. Teyler,et al.  Hyperpolarizing and depolarizing GABAA receptor-mediated dendritic inhibition in area CA1 of the rat hippocampus. , 1991, Journal of neurophysiology.

[44]  P. H. Moore,et al.  Stress-induced elevations of gamma-aminobutyric acid type A receptor-active steroids in the rat brain. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[45]  S. Paul,et al.  Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor. , 1986, Science.

[46]  A. Snowman,et al.  Chloride-dependent enhancement by barbiturates of gamma-aminobutyric acid receptor binding , 1982, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[47]  R. Nicoll,et al.  Pharmacological evidence for two kinds of GABA receptors on rat hippocampal pyramidal cells studied in vitro , 1982, The Journal of physiology.

[48]  D. Bayliss,et al.  Inhibition of a background potassium channel by Gq protein alpha-subunits. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[49]  R. Romeo.  Neuroendocrine and behavioral development during puberty: a tale of two axes. , 2005, Vitamins and hormones.

[50]  B. Orser,et al.  Tonic inhibition in mouse hippocampal CA1 pyramidal neurons is mediated by alpha5 subunit-containing gamma-aminobutyric acid type A receptors. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[51]  T. Bäckström,et al.  Allopregnanolone-stimulated GABA-mediated chloride ion flux is inhibited by 3beta-hydroxy-5alpha-pregnan-20-one (isoallopregnanolone). , 2003, Brain research.

[52]  K. Wohlfarth,et al.  Enhanced neurosteroid potentiation of ternary GABA(A) receptors containing the delta subunit. , 2002, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[53]  R. Macdonald,et al.  Alpha1 and alpha6 subunits specify distinct desensitization, deactivation and neurosteroid modulation of GABA(A) receptors containing the delta subunit. , 2002, Neuropharmacology.

[54]  B. Orser,et al.  Distinct Functional and Pharmacological Properties of Tonic and Quantal Inhibitory Postsynaptic Currents Mediated by ␥-aminobutyric Acid a Receptors in Hippocampal Neurons , 2001 .

[55]  R. Macdonald,et al.  GABAA receptor subunit gamma2 and delta subtypes confer unique kinetic properties on recombinant GABAA receptor currents in mouse fibroblasts. , 1999, The Journal of physiology.

[56]  D. Bitrán,et al.  Anxiolytic effects of the neuroactive steroid pregnanolone (3 alpha-OH-5 beta-pregnan-20-one) after microinjection in the dorsal hippocampus and lateral septum. , 1999, Brain research.

[57]  J. Eccles,et al.  Are adolescents the victims of raging hormones: evidence for activational effects of hormones on moods and behavior at adolescence. , 1992, Psychological bulletin.