Blood choline and response to clonazepam and haloperidol in Tourette's syndrome

ABSTRACT– This paper reports the results of a single blind clinical study of drug treatment response of 20 patients with Tourette's syndrome to haloperidol and clonazepam. Because patients with Tourette's syndrome have been reported to have increased red blood cell choline levels, choline levels were examined in relation to treatment response. Differential drug treatment response was found among patients with high versus low red blood cell‐to‐plasma choline ratios. Patients with high red blood cell‐to‐plasma choline ratios responded better to clonazepam than to haloperidol. This suggests that there may be two distinct subtypes of patients with Tourette's syndrome.

[1]  W. Matthews,et al.  SOMNAMBULISM IN CHILDREN WITH TOURETTE SYNDROME , 1984, Developmental medicine and child neurology.

[2]  C. Tanner,et al.  Cholinergic mechanisms in Tourette syndrome , 1982, Neurology.

[3]  D. Cohen,et al.  School avoidance and social phobia triggered by haloperidol in patients with Tourette's disorder. , 1981, The American journal of psychiatry.

[4]  K. Kidd,et al.  Familial pattern and transmission of Gilles de la Tourette syndrome and multiple tics. , 1981, Archives of general psychiatry.

[5]  D. Weinberger,et al.  HLA-A2 Antigen in Schizophrenic Patients with Reversed Cerebral Asymmetry , 1981, British Journal of Psychiatry.

[6]  Stahl Sm,et al.  Physostigmine in Tourette syndrome: evidence for cholinergic underactivity. , 1981, The American journal of psychiatry.

[7]  B. Shaywitz,et al.  Clonidine ameliorates Gilles de la Tourette syndrome. , 1980, Archives of general psychiatry.

[8]  S. Peroutka,et al.  Relationship of neuroleptic drug effects at brain dopamine, serotonin, alpha-adrenergic, and histamine receptors to clinical potency. , 1980, The American journal of psychiatry.

[9]  W. Weiner,et al.  Dopaminergic antagonism of L‐5‐hydroxytryptophan‐induced myoclonic jumping behavior , 1979, Neurology.

[10]  C. Albano,et al.  Interactions between central monoaminergic systems: dopamine-serotonin. , 1979, Journal of neurology, neurosurgery, and psychiatry.

[11]  G. S. Golden,et al.  Tics and Tourette syndrome. , 1979, Hospital practice.

[12]  E. Tolosa,et al.  Meiges disease: a clinical form of facial convulsion, bilateral and medial. , 1979, Archives of neurology.

[13]  I. Hanin.  Choline and lecithin in the treatment of neurologic disorders. , 1979, The New England journal of medicine.

[14]  C. F. Reynolds,et al.  Blepharospasm: Successful treatment with clonazepam , 1979, Annals of neurology.

[15]  J. Nathanson,et al.  Central biogenic amine metabolism in children with the syndrome of chronic multiple tics of Gilles de la Tourette: norepinephrine, serotonin, and dopamine. , 1979, Journal of the American Academy of Child Psychiatry.

[16]  G. S. Golden,et al.  The effect of central nervous system stimulants on tourette syndrome , 1977, Annals of neurology.

[17]  D. Comings,et al.  Red blood cell choline in Tourette syndrome. , 1982, Advances in neurology.

[18]  D. Kupfer,et al.  Acetylcholine and Choline in Human Plasma and Red Blood Cells: A Gas Chromatograph Mass Spectrometric Evaluation , 1978 .